David Peaper, MD, PhD
Research & Publications
Biography
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Research Summary
I am interested in the interaction between basic and clinical sciences and using the tools and resources of the clinical and basic science research communities to further our understanding of the mechanisms of organism pathogenesis and improving diagnostics available for the more rapid and/or accurate identification of infectious diseases. I collaborate with Yale scientists to increase the clinical relevance of research projects as well as identify current gaps in diagnostic testing where advanced methods may improve patient care.
I also have an interest in both assessing the outcomes of laboratory interventions and testing practices on patient care and identifying ways to streamline laboratory practices to improve our ability to provide test results. We have identified areas for improvement for the implementation of rapid respiratory virus testing and its impact on antibiotic overuse. Additionally, working with others at Yale and YNHH, we have studied a number of interventions in practices to improve test utilization and decrease rates of hospital acquired infections.
Coauthors
Research Interests
Bacterial Infections; Influenza, Human; Clostridioides difficile; Clinical Laboratory Techniques; Organisms
Selected Publications
- Rapid diagnosis of influenza: state of the art.Peaper DR, Landry ML. Rapid diagnosis of influenza: state of the art. Clinics In Laboratory Medicine 2014, 34: 365-85. PMID: 24856533, PMCID: PMC7172071, DOI: 10.1016/j.cll.2014.02.009.
- Response to mold contamination of intravenous magnesium sulfate produced by a compounding pharmacy.Boyce JM, Lee L, Topal J, Peaper DR, Balcezak T. Response to mold contamination of intravenous magnesium sulfate produced by a compounding pharmacy. JAMA Internal Medicine 2014, 174: 630-1. PMID: 24493036, DOI: 10.1001/jamainternmed.2013.13772.
- Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients.Green DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR. Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients. Journal Of Clinical Microbiology 2016, 54: 2950-2955. PMID: 27654334, PMCID: PMC5121384, DOI: 10.1128/JCM.01579-16.
- The contribution of extended-spectrum β-lactamases to multidrug-resistant infections in children.Murray TS, Peaper DR. The contribution of extended-spectrum β-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-31. PMID: 25565574, DOI: 10.1097/MOP.0000000000000182.
- Use of imipenem to detect KPC, NDM, OXA, IMP, and VIM carbapenemase activity from gram-negative rods in 75 minutes using liquid chromatography-tandem mass spectrometry.Kulkarni MV, Zurita AN, Pyka JS, Murray TS, Hodsdon ME, Peaper DR. Use of imipenem to detect KPC, NDM, OXA, IMP, and VIM carbapenemase activity from gram-negative rods in 75 minutes using liquid chromatography-tandem mass spectrometry. Journal Of Clinical Microbiology 2014, 52: 2500-5. PMID: 24789180, PMCID: PMC4097713, DOI: 10.1128/JCM.00547-14.