Skip to Main Content

David Matuskey, MD

Assistant Professor of Radiology and Biomedical Imaging and of Psychiatry and of Neurology; Director, NeuroPET Imaging Program, Radiology and Biomedical Imaging; Medical Director, Yale Positron Emission Tomography (PET) Center

Research Summary

I am a board certified psychiatrist and neuropsychiatrist with research work that has been translational in nature and focused on elucidating the underlying pathology of conditions such as Autism Spectrum Disorder, substance abuse and Parkinson's disease with an aim to find effective clinical treatments guided by molecular neuroimaging. Studies have included using in-vivo PET imaging to investigate the role of receptors such as dopamine D3, serotonin 1B and 6, MGlur5 and kappa, neuroinflammation, and most recently, synaptic density (SV2A) in clinical and nonclinical populations. Ongoing interests include imaging addiction and neuropsychiatric disorders and demographic, social and environmental factors influencing our brain.

Coauthors

Research Interests

Autistic Disorder; Mental Disorders; Social Class; Molecular Imaging; Neuropsychiatry; Neuroimaging; Addiction Medicine

Public Health Interests

Global Health; Mental Health

Selected Publications

Clinical Trials

ConditionsStudy Title
Diseases of the Nervous System; HIV/AIDS; Infectious Diseases; COVID-19 Inpatient; COVID-19 OutpatientHIV Associated Reservoirs and Comorbidities (The HARC Plus Study)
Addictive BehaviorsPET Imaging of Microglia with [11C]PBR28 in Opioid Dependent and Healthy Control Subjects
Mental Health & Behavioral ResearchEligibility for Participation in Neuroimaging Studies
Addictive Behaviors; Alcohol Addiction; Mental Health & Behavioral ResearchGlutamate-Glutamine Cycling (VCYC) during Cocaine Abstinence using 1H-MRS
Diseases of the Lung; Diseases of the Respiratory SystemsSafety, Tolerability, Kinetics, and Repeatability of the Novel LPA1 PET Ligand 18F-BMS-986327
Child Development & AutismPET Imaging Study for Young Adults with ASD
Diseases of the Nervous SystemImaging the Dopamine Transporter in Parkinson's Disease
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco AddictionImaging smoking-induced dopamine release utilizing PET imaging and nicotine patches
Mental Health & Behavioral ResearchMechanistic Evaluation of Guanfacine on Drinking Behavior
Diseases of the Nervous System; Alzheimer's DiseaseSafety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
Addictive BehaviorsImaging Synaptic Density in Cocaine and Opiate Addiction In Vivo using 11C-UCB-J PET
Diseases of the Nervous System; Mental Health & Behavioral ResearchExamination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral Research; Tobacco AddictionImaging Tobacco Smoking Withdrawal using [11C]PHNO
Diseases of the Nervous System; Mental Health & Behavioral ResearchC4 Gene Dose Effects using 11C-UCB-J PET
Mental Health & Behavioral ResearchVitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD
Mental Health & Behavioral ResearchImaging Microglial Activation in PTSD wITH PET
Diseases of the Nervous SystemImaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
Mental Health & Behavioral ResearchImaging mGluR5 and synaptic density in psychiatric disorders
Addictive Behaviors; Alcohol Addiction; Mental Health & Behavioral Research; Tobacco AddictionDetermining Eligibility for Neuroimaging Research Studies
Alzheimer's DiseaseAlzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol (ADNI3)