David Matuskey, MD

• Alan Anticevic
• Ania Jastreboff
• Ansel Hillmer
• Brian Pittman
• Carolyn M Mazure
• Chadi Abdallah
• Chiang-Shan Ray Li
• Christopher Pittenger
• David Labaree
• Dennis Spencer
• Dustin Scheinost
• Evan Morris
• Gerard Sanacora
• Graeme Mason
• Gustavo A. Angarita
• Irina Esterlis
• Jaime Ide
• Jason Bini
• Jason Cai
• Jean-Dominique Gallezot
• Jim Ropchan
• John Krystal
• Kalyani Subramanyam
• Kelly Cosgrove
• Kevin O'Connor
• Lihong Jiang
• Maggie Taylor Davis
• Marc Potenza
• Marina Picciotto
• Matthew J Girgenti
• Meaghan Lavery
• Michelle Hampson
• Mika Naganawa
• Ming-Kai Chen
• MingQiang Zheng
• Nabeel Nabulsi
• Nicole DellaGioia
• Patrick Worhunsky
• Paul Geha
• Peter Morgan
• Ralitza Gueorguieva
• Richard Carson
• Robert Pietrzak
• Roni Dhaher
• Shannan Henry
• Sheng Zhang
• Sherry McKee
• Shivani Bhatt
• Songye Li
• Sophie E Holmes
• Steven Southwick
• Tore Eid
• Vince Calhoun
• Yasmin Zakiniaeiz
• Yiyun Huang
• Zubin Bhagwagar

Autistic Disorder; Mental Disorders; Social Class; Molecular Imaging; Neuropsychiatry; Neuroimaging; Addiction Medicine

Global Health; Mental Health

• PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases.Cai Z, Li S, Matuskey D, Nabulsi N, Huang Y. PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases. Neuroscience Letters 2019, 691:44-50.
• The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study.Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43:1052-1058.
• Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression. Molecular Psychiatry 2018, 23:824-832.
• Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO.Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2016, 41:3042-3050.
• Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers.Matuskey D, Worhunksy P, Correa E, Pittman B, Gallezot JD, Nabulsi N, Ropchan J, Sreeram V, Gudepu R, Gaiser E, Cosgrove K, Ding YS, Potenza MN, Huang Y, Malison RT, Carson RE. Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers. NeuroImage 2016, 130:241-247.
• Imaging synaptic density in the living human brain.Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Imaging synaptic density in the living human brain. Science Translational Medicine 2016, 8:348ra96.
• A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.Matuskey D, Gaiser EC, Gallezot JD, Angarita GA, Pittman B, Nabulsi N, Ropchan J, MaCleod P, Cosgrove KP, Ding YS, Potenza MN, Carson RE, Malison RT. A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO. Drug And Alcohol Dependence 2015, 154:167-73.
• Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943.Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943. European Journal Of Nuclear Medicine And Molecular Imaging 2015, 42:468-77.
• Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112:12468-73.
• Memory reconsolidation for treatment-resistant aggression and self-injurious behaviors.Matuskey D, Sondik T. Memory reconsolidation for treatment-resistant aggression and self-injurious behaviors. Journal Of Clinical Psychopharmacology 2015, 35:104-5.
• Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT. Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. Biological Psychiatry 2014, 76:816-22.
• Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO.Matuskey D, Gallezot JD, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Hannestad J, Lim K, Zheng MQ, Lin SF, Labaree D, Potenza MN, Carson RE, Malison RT, Ding YS. Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO. Drug And Alcohol Dependence 2014, 139:100-5.
• Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals.Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214:116-21.
• Age effects on serotonin receptor 1B as assessed by PET.Matuskey D, Pittman B, Planeta-Wilson B, Walderhaug E, Henry S, Gallezot JD, Nabulsi N, Ding YS, Bhagwagar Z, Malison R, Carson RE, Neumeister A. Age effects on serotonin receptor 1B as assessed by PET. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2012, 53:1411-4.
• A single-day paradigm of self-regulated human cocaine administration.Matuskey D, Pittman B, Chen JI, Wanyiri J, Nadim H, Jatlow P, Gueorguieva R, Potenza MN, Morgan PT, Bhagwagar Z, Malison RT. A single-day paradigm of self-regulated human cocaine administration. Pharmacology, Biochemistry, And Behavior 2012, 103:95-101.
• A multistudy analysis of the effects of early cocaine abstinence on sleep.Matuskey D, Pittman B, Forselius E, Malison RT, Morgan PT. A multistudy analysis of the effects of early cocaine abstinence on sleep. Drug And Alcohol Dependence 2011, 115:62-6.
• Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients.Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107:14455-9.
• Gray matter volume correlates of global positive alcohol expectancy in non-dependent adult drinkers.Ide JS, Zhang S, Hu S, Matuskey D, Bednarski SR, Erdman E, Farr OM, Li CS. Gray matter volume correlates of global positive alcohol expectancy in non-dependent adult drinkers. Addiction Biology 2014, 19:895-906.
• The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults.Farr OM, Zhang S, Hu S, Matuskey D, Abdelghany O, Malison RT, Li CS. The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults. The International Journal Of Neuropsychopharmacology / Official Scientific Journal Of The Collegium Internationale Neuropsychopharmacologicum (CINP) 2014, 17:1177-91.
• The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults.Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults. Experimental And Clinical Psychopharmacology 2014, 22:154-65.
• Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures.Davis MT, DellaGioia N, Matuskey D, Harel B, Maruff P, Pietrzak RH, Esterlis I. Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures. Journal Of Affective Disorders 2017, 218:82-85.
• Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114:8390-8395.
• Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder.Worhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE. Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder. NeuroImage 2017, 148:343-351.
• Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biological Psychiatry : Cognitive Neuroscience And Neuroimaging 2017, 2:449-456.
• Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2018, 38:2041-2052.
• Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder.Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43:1119-1127.
• Evaluation of (-)-[18 F]Flubatine-specific binding: Implications for reference region approaches.Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin SF, Esterlis I, Carson RE, Huang Y, Cosgrove KP. Evaluation of (-)-[18 F]Flubatine-specific binding: Implications for reference region approaches. Synapse (New York, N.Y.) 2018, 72.
• Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence.Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence. Chronic Stress (Thousand Oaks, Calif.) 2018, 2.
• Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences.Smith CT, Crawford JL, Dang LC, Seaman KL, San Juan MD, Vijay A, Katz DT, Matuskey D, Cowan RL, Morris ED, Zald DH, Samanez-Larkin GR. Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2019, 39:822-833.
• Positron emission tomography imaging of the γ-aminobutyric acid system.Andersson JD, Matuskey D, Finnema SJ. Positron emission tomography imaging of the γ-aminobutyric acid system. Neuroscience Letters 2019, 691:35-43.
• Editorial.Matuskey D. Editorial. Neuroscience Letters 2019, 691:1-2.
• Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain.Gallezot JD, Nabulsi NB, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek G, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2019, 60:1140-1146.
• First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2020, 40:695-704.
• Lower synaptic density is associated with depression severity and network alterations.Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10:1529.
• A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas JM, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE. A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers. Epilepsia 2019, 60:958-967.
• Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers.Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2019, 44:1714-1719.
• Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2019, 44:1720-1727.
• In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita-Africano G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116:11490-11495.
• Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2019, 44:2205-2211.
• Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study.Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study. European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46:2329-2338.
• Further in vivo characterization of [11 C]-(+)-PHNO uptake into a retina-like region of interest in humans.Caravaggio F, Worhunsky P, Graff-Guerrero A, Matuskey D. Further in vivo characterization of [11 C]-(+)-PHNO uptake into a retina-like region of interest in humans. Synapse (New York, N.Y.) 2020, 74:e22135.