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David J Leffell, MD

David P. Smith Professor of Dermatology and Professor of Surgery (Otolaryngology and Plastic); Section Chief, Dermatologic Surgery and Cutaneous Oncology

Contact Information

David J Leffell, MD

Office Location

Mailing Address

  • Dermatology

    PO Box 208059, 333 Cedar Street

    New Haven, CT 06520-8059

    United States

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Yale Medicine

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Research Summary

Dr. Leffell and colleagues discovered the skin cancer gene, PTCH, in 1996 and have directed subsequent research towards understanding how skin cancer develops. Other research includes studies of the p53 gene in skin cancer, epidemiology of skin cancer, innovative diagnostic devices and wound healing.

Extensive Research Description

When I founded the Dermatologic Surgery program at Yale in 1988, my goal was to combine state of the art patient care with clinical research. We often talk about bench to bedside as the framework for discovery in medicine but in fact most innovations related to disease proceed the other way: from bedside to bench. A doctor recognizes a pattern in a particular disease or makes a novel observation in a patient and that raises questions for investigation in the laboratory. Early in my career I observed an increase in basal cell cancer in young women. This was unusual for a disease typically noted in older men. Investigation into sun practices and related issues became the basis for a component of a SPORE grant that the department was awarded. Because we treat a very large number of skin cancers and melanoma and perform reconstructive surgery, a large focus of our research has also been on wound healing. We have published on the use of artificial skin substitutes to facilitate healing and I am involved with a commercial entity with a connexin43 molecule currently in clinical trials. In a broad sense my research collaborations extend from skin cancer in the immune compromised, to the biology of skin cancer in general and its epidemiology to the development of innovative treatments.

Coauthors

Research Interests

Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Epidermis; Head and Neck Neoplasms; Melanoma; Skin Neoplasms; Ultraviolet Rays; Wound Healing; Mohs Surgery; Genes, p53; Keratosis, Actinic

Selected Publications

  • In vivo fluorescence of human skin. A potential marker of photoaging.Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI. In vivo fluorescence of human skin. A potential marker of photoaging. Archives Of Dermatology 1988, 124: 1514-8. PMID: 3421727.
  • Aggressive-growth basal cell carcinoma in young adults.Leffell DJ, Headington JT, Wong DS, Swanson NA. Aggressive-growth basal cell carcinoma in young adults. Archives Of Dermatology 1991, 127: 1663-7. PMID: 1952969.
  • Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-20. PMID: 8483937, PMCID: PMC46477.
  • Sunburn and p53 in the onset of skin cancer.Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. Sunburn and p53 in the onset of skin cancer. Nature 1994, 372: 773-6. PMID: 7997263, DOI: 10.1038/372773a0.
  • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85: 841-51. PMID: 8681379.
  • Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma.Gailani MR, Leffell DJ, Ziegler A, Gross EG, Brash DE, Bale AE. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. Journal Of The National Cancer Institute 1996, 88: 349-54. PMID: 8609643.
  • Tumor suppressor gene mutations and photocarcinogenesis.Ziegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor suppressor gene mutations and photocarcinogenesis. Photochemistry And Photobiology 1996, 63: 432-5. PMID: 8934758.
  • The dermatologic surgery issue: A new face for the ARCHIVESLeffell DJ, Arndt KA. The dermatologic surgery issue: A new face for the ARCHIVES Archives Of Dermatology 2000, 136: 1404. PMID: 11074706, DOI: 10.1001/archderm.136.11.1404.
  • Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases.Chen T, Yan W, Wells RG, Rimm DL, McNiff J, Leffell D, Reiss M. Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases. International Journal Of Cancer. Journal International Du Cancer 2001, 93: 653-61. PMID: 11477574, DOI: 10.1002/ijc.1381.
  • Human cadaveric allograft for repair of nasal defects after extirpation of Basal cell carcinoma by Mohs micrographic surgery.Carucci JA, Kolenik SA, Leffell DJ. Human cadaveric allograft for repair of nasal defects after extirpation of Basal cell carcinoma by Mohs micrographic surgery. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 340-3. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.
  • Histopathologic misdiagnoses and their clinical consequences.Olhoffer IH, Lazova R, Leffell DJ. Histopathologic misdiagnoses and their clinical consequences. Archives Of Dermatology 2002, 138: 1381-3. PMID: 12374557, DOI: 10.1001/archderm.138.10.1381.
  • Clinical efficacy of devices for nonablative photorejuvenation.Leffell DJ. Clinical efficacy of devices for nonablative photorejuvenation. Archives Of Dermatology 2002, 138: 1503-8. PMID: 12437458, DOI: 10.1001/archderm.138.11.1503.
  • Repair of a defect of the lower lip.Carucci JA, Kolenik SA, Leffell DJ. Repair of a defect of the lower lip. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 195-6. PMID: 11860438, DOI: 10.1046/j.1524-4725.2002.01250.x.
  • Complications in dermatologic surgery: how safe is safe?Aasi SZ, Leffell DJ. Complications in dermatologic surgery: how safe is safe? Archives Of Dermatology 2003, 139: 213-4. PMID: 12588228, DOI: 10.1001/archderm.139.2.213.
  • PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer.Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. The British Journal Of Dermatology 2005, 152: 868-73. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.
  • Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome.Bhattacharjee P, Leffell D, McNiff JM. Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome. Journal Of Cutaneous Pathology 2005, 32: 638-41. PMID: 16176303, DOI: 10.1111/j.0303-6987.2005.00384.x.
  • Bilobed transposition flap.Aasi SZ, Leffell DJ. Bilobed transposition flap. Dermatologic Clinics 2005, 23: 55-64, vi. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.
  • Mohs micrographic surgery: established uses and emerging trends.Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology (Williston Park, N.Y.) 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.
  • Correlation of embryonic fusion planes with the anatomical distribution of basal cell carcinoma.Newman JC, Leffell DJ. Correlation of embryonic fusion planes with the anatomical distribution of basal cell carcinoma. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2007, 33: 957-64; discussion 965. PMID: 17661939, DOI: 10.1111/j.1524-4725.2007.33198.x.
  • Management of nonmelanoma skin cancer in 2007.Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Clinical Practice. Oncology 2007, 4: 462-9. PMID: 17657251, DOI: 10.1038/ncponc0883.
  • Mohs micrographic surgery histopathology concordance.Mariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance. Journal Of The American Academy Of Dermatology 2009, 60: 94-8. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.
  • Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining.Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-52. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.
  • Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake.Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. The American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.
  • Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults.Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Archives Of Biochemistry And Biophysics 2010, 504: 34-9. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.
  • Squamoid eccrine ductal carcinoma: a case report and review of the literature.Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid eccrine ductal carcinoma: a case report and review of the literature. The American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/DAD.0b013e3181b623c4.
  • Melanoma and nevi: detection and diagnosis.Choi JN, Hanlon A, Leffell D. Melanoma and nevi: detection and diagnosis. Current Problems In Cancer 2011, 35: 138-61. PMID: 21911179, DOI: 10.1016/j.currproblcancer.2011.07.005.
  • Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype.Heffelfinger C, Ouyang Z, Engberg A, Leffell DJ, Hanlon AM, Gordon PB, Zheng W, Zhao H, Snyder MP, Bale AE. Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype. G3 (Bethesda, Md.) 2012, 2: 279-86. PMID: 22384406, PMCID: PMC3284335, DOI: 10.1534/g3.111.001115.
  • Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases.Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-23. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.
  • Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy.Bunick CG, Leffell D, Bosenberg M, Yahalom J, Choi JN. Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. Journal Of The American Academy Of Dermatology 2012, 67: e225-6. PMID: 23062927, DOI: 10.1016/j.jaad.2012.04.025.
  • Indoor tanning and risk of early-onset basal cell carcinoma.Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. Journal Of The American Academy Of Dermatology 2012, 67: 552-62. PMID: 22153793, PMCID: PMC3307842, DOI: 10.1016/j.jaad.2011.11.940.
  • Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma.Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. The Journal Of Investigative Dermatology 2012, 132: 1272-9. PMID: 22158557, PMCID: PMC3305835, DOI: 10.1038/jid.2011.402.
  • Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates.Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates. BMC Public Health 2012, 12: 118. PMID: 22324969, PMCID: PMC3340300, DOI: 10.1186/1471-2458-12-118.
  • Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma.Cartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma. JAMA Dermatology 2013, 149: 1110-1. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.
  • Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status.Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. The British Journal Of Nutrition 2013, 110: 911-7. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/S000711451200582X.
  • Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face.Hanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face. Journal Of The American Academy Of Dermatology 2013, 69: 1070-2. PMID: 24238178, DOI: 10.1016/j.jaad.2013.02.032.
  • Systemic glucocorticoid use and early-onset basal cell carcinoma.Troche JR, Ferrucci LM, Cartmel B, Leffell DJ, Bale AE, Mayne ST. Systemic glucocorticoid use and early-onset basal cell carcinoma. Annals Of Epidemiology 2014, 24: 625-7. PMID: 24958637, PMCID: PMC4119504, DOI: 10.1016/j.annepidem.2014.05.009.
  • Novel gene identified in an exome-wide association study of tanning dependence.Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome-wide association study of tanning dependence. Experimental Dermatology 2014, 23: 757-9. PMID: 25041255, PMCID: PMC4204712, DOI: 10.1111/exd.12503.
  • Alcohol intake and early-onset basal cell carcinoma in a case-control study.Zhang Y, Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Alcohol intake and early-onset basal cell carcinoma in a case-control study. The British Journal Of Dermatology 2014, 171: 1451-7. PMID: 25059635, PMCID: PMC4272627, DOI: 10.1111/bjd.13291.
  • Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study.Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study. European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ECP) 2014, 23: 296-302. PMID: 24841641, PMCID: PMC4059399, DOI: 10.1097/CEJ.0000000000000037.
  • Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas.Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2014, 70: 70-4. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.
  • Point of care cutaneous imaging technology in melanoma screening and mole mapping.Higgins HW, Lee KC, Leffell DJ. Point of care cutaneous imaging technology in melanoma screening and mole mapping. F1000prime Reports 2014, 6: 34. PMID: 24860656, PMCID: PMC4017910, DOI: 10.12703/P6-34.
  • Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype.Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-83. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.
  • Melanoma in situ: Part I. Epidemiology, screening, and clinical features.Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part I. Epidemiology, screening, and clinical features. Journal Of The American Academy Of Dermatology 2015, 73: 181-90, quiz 191-2. PMID: 26183967, DOI: 10.1016/j.jaad.2015.04.014.
  • Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo.Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2015, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.
  • Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery.Kim J, Singh Maan H, Cool AJ, Hanlon AM, Leffell DJ. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. The Journal Of Clinical And Aesthetic Dermatology 2015, 8: 24-9. PMID: 25741400, PMCID: PMC4345930.
  • Melanoma in situ: Part II. Histopathology, treatment, and clinical management.Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part II. Histopathology, treatment, and clinical management. Journal Of The American Academy Of Dermatology 2015, 73: 193-203; quiz 203-4. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.
  • Subsequent skin cancer in patients with early-onset basal cell carcinoma.Berlin NL, Ferrucci LM, Cartmel B, Wang SY, Leffell DJ, McNiff JM, Mayne ST. Subsequent skin cancer in patients with early-onset basal cell carcinoma. The Australasian Journal Of Dermatology 2015, 56: 236-7. PMID: 26201376, DOI: 10.1111/ajd.12338.
  • Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people.Molinaro AM, Ferrucci LM, Cartmel B, Loftfield E, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people. American Journal Of Epidemiology 2015, 181: 908-16. PMID: 25858289, PMCID: PMC4445390, DOI: 10.1093/aje/kwu356.
  • A strategy for the successful management of dermatofibrosarcoma protuberans.Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A strategy for the successful management of dermatofibrosarcoma protuberans. Annals Of Plastic Surgery 2015, 74: 80-4. PMID: 23788146, DOI: 10.1097/SAP.0b013e3182898692.
  • Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age.Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age. Vaccine 2015, 33: 6622-8. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.
  • Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach.Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2016, 74: 356-62. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.
  • Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity.Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-65. PMID: 27220356, DOI: 10.1111/cup.12738.
  • Body mass index, height and early-onset basal cell carcinoma in a case-control study.Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiology 2017, 46: 66-72. PMID: 28039770, PMCID: PMC5272867, DOI: 10.1016/j.canep.2016.12.007.
  • Well-differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63.Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well-differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.
  • Emerging concepts and recent advances in basal cell carcinoma.Totonchy M, Leffell D. Emerging concepts and recent advances in basal cell carcinoma. F1000Research 2017, 6: 2085. PMID: 29259776, PMCID: PMC5717469, DOI: 10.12688/f1000research.11314.1.
  • Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases.Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.
  • Predictors of tanning dependence in white non-Hispanic females and males.Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non-Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology : JEADV 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.
  • Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum.Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/DSS.0000000000001465.
  • Transparency and Dermatologic Device Approval by the US Food and Drug Administration.Ezaldein HH, Scott JF, Yin ES, Ventura A, DeRuyter NP, Leffell DJ. Transparency and Dermatologic Device Approval by the US Food and Drug Administration. JAMA Dermatology 2018, 154: 273-280. PMID: 29365020, PMCID: PMC5885836, DOI: 10.1001/jamadermatol.2017.5757.
  • Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma.Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. Journal Of The American Academy Of Dermatology 2018, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.
  • Cutaneous immunohistochemical staining pattern of p53β isoforms.Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120-1122. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.
  • Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease.Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2019, 45: 1002-1005. PMID: 31260417, DOI: 10.1097/DSS.0000000000001706.
  • Optical Spectroscopy as a Method for Skin Cancer Risk Assessment.Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.
  • Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness.Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2020, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.
  • Melanoma in situ: Don't make the cure worse than the disease.Prassinos A, Glusac E, Leffell DJ. Melanoma in situ: Don't make the cure worse than the disease. Journal Of The American Academy Of Dermatology 2021, 85: 520. PMID: 32387662, DOI: 10.1016/j.jaad.2020.04.168.
  • Predicting outcomes following second intent healing of periocular surgical defects.Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2021, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.
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