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David A. Hafler, MD, FANA

William S. and Lois Stiles Edgerly Professor of Neurology and Professor of Immunobiology; Chair, Department of Neurology; Neurologist-in-Chief, Yale New Haven Hospital

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Lab Location

Hafler Lab
300 George Street, Ste 3rd Floor
New Haven, CT 06511
Appointments:203.737.4802

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Chair's Office, Department of Neurology
Lippard Lab for Clinical Investigation
15 York Street, Ste Rm 912
New Haven, CT 06510
Chair's Office:203.785.5947

Mailing Address

Neurology
PO Box 208018. 15 York St
New Haven, CT 06520-8018
United States

Hafler Lab

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Research Summary

Hafler, in many respects, is credited with identifying the central mechanisms underlying the likely cause of MS. His early seminal work demonstrated that the disease began in the blood, not the brain, which eventually led to the development of Tysabri to treat the disease by blocking the movement of immune cells from the blood to the brain. He was the first to identify myelin-reactive T cells in the disease, published in Nature, showing that indeed, MS was an autoimmune disorder. He then went on to show why autoreactive T cells were dysregulated by the first identification of regulatory T cells in humans followed by demonstration of their dysfunctional state in MS. As a founding, Broad Institute member, Hafler identified the genes that cause MS, published in the New England Journal of Medicine and Nature. More recently, he identified the key transcription factors and signaling pathways associated with MS genes as potential treatment targets. Finally, he recently discovered that salt drives induction of these pathogenic myelin reactive T cells, both works published in Nature. Hafler was the Breakstone Professor of Neuroscience at Harvard, and became Chairman of Neurology at Yale in 2009, where he has built an outstanding clinical and research program that strongly integrates medical sciences. He has received numerous honors including the Dystel Prize from the AAN for his MS research and is among the most highly cited living neurologists and is a member of the National Academy of Medicine.

Specialized Terms: Neuroimmunology; Multiple Sclerosis; Autoimmunity; Genetics; Immunobiology

Extensive Research Description

Hafler is a major force in bridging basic immunology, genetics, and neurology deeply probing mechanisms to understand MS. His seminal work in 1985 demonstrating systemic immune involvement in MS (NEJM, 1985) was followed by the first identification of myelin, autoreactive T cells in MS (Nature 1990). In 2004, Hafler was the first to identify human FoxP3 regulatory T cells and then demonstrated that they are defective in MS (JEM, Nature Med, 2011). In 2001, he co-led the international effort that identified the first MS genes outside of MHC (NEJM, 2007) now with over 100 identified genes (Nature 2011). In 2009 Hafler was recruited to become Chairman of Yale Neurology and Professor of Neurology and Immunobiology where he has rapidly built an outstanding clinical program that strongly integrates medical sciences. His scientific leadership has continued where he has deeply examined the function of MS associated risk haplotypes demonstrating their significant biologic effects (JCI 2014), identified NaCl as an environmental cause of of inflammation (Nature 2013), and epigentically fine-mapped MS causal variants discovering the molecular pathways causing MS (Nature 2014). He has received innumerable professional distinctions including being becoming a Jacob Javits Scholar of the NIH, ASCI membership, the ISI most highly cited list, the University of Miami Distinguished Alumni Award and the prestigious John Dystel Prize from the American Academy of Neurology and is a member of the National Academy of Medicine.

Coauthors

Research Interests

Brain Neoplasms; Multiple Sclerosis; Neurology; Neurosciences; Autoimmunity

Public Health Interests

Cancer; Genetics, Genomics, Epigenetics; HIV/AIDS; Immunology; Nutrition

Selected Publications

Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS.Lucca LE, Lerner BA, Park C, DeBartolo D, Harnett B, Kumar VP, Ponath G, Raddassi K, Huttner A, Hafler DA, Pitt D. Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS. Neurology® Neuroimmunology & Neuroinflammation 2020, 7.
CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome.Choileáin SN, Kleinewietfeld M, Raddassi K, Hafler DA, Ruff WE, Longbrake EE. CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome. Journal Of Translational Autoimmunity 2020, 3:100032.
Transcriptomic and clonal characterization of T cells in the human central nervous system.Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA. Transcriptomic and clonal characterization of T cells in the human central nervous system. Science Immunology 2020, 5.
Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity.Lincoln MR, Axisa PP, Hafler DA. Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity. Current Opinion In Immunology 2020, 67:50-56.
Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans.Nakatsuka N, Patterson N, Patsopoulos NA, Altemose N, Tandon A, Beecham AH, McCauley JL, Isobe N, Hauser S, De Jager PL, Hafler DA, Oksenberg JR, Reich D. Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans. Scientific Reports 2020, 10:16902.
Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo. Journal Of Autoimmunity 2019, 96:40-49.
TIGIT signaling restores suppressor function of Th1 Tregs.Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA. TIGIT signaling restores suppressor function of Th1 Tregs. JCI Insight 2019, 4.
Multiple sclerosis enters a grey area.Pappalardo JL, Hafler DA. Multiple sclerosis enters a grey area. Nature 2019, 566:465-466.
Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. Journal Of Immunology (Baltimore, Md. : 1950) 2019, 202:2210-2219.
From Big Data to Precision Medicine.Hulsen T, Jamuar SS, Moody AR, Karnes JH, Varga O, Hedensted S, Spreafico R, Hafler DA, McKinney EF. From Big Data to Precision Medicine. Frontiers In Medicine 2019, 6:34.
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. Nature Microbiology 2019, 4:948-955.
Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients.James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Harley JB, Robinson W, Hafler DA, O'Connor KC, Buckner J, Guthridge JM, Norris JM, Holers VM. Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. EBioMedicine 2019, 42:76-85.
Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49].Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49]. Journal Of Autoimmunity 2019, 102:179.
Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology 2019, 20:943.
AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.Kitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease. EMBO Reports 2019, 20:e48624.
Siponimod Chips Away at Progressive MS.Longbrake EE, Hafler DA. Siponimod Chips Away at Progressive MS. Cell 2019, 179:1440.
Regulatory T Cells: From Discovery to Autoimmunity.Kitz A, Singer E, Hafler D. Regulatory T Cells: From Discovery to Autoimmunity. Cold Spring Harbor Perspectives In Medicine 2018, 8.
Multiple sclerosis.Cotsapas C, Mitrovic M, Hafler D. Multiple sclerosis. Handbook Of Clinical Neurology 2018, 148:723-730.
Regulatory T cells in autoimmune disease.Dominguez-Villar M, Hafler DA. Regulatory T cells in autoimmune disease. Nature Immunology 2018, 19:665-673.
Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Rhaddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D. Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. Lab On A Chip 2018, 18:2396-2409.
Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV.Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 2018, 3.
Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology 2018, 19:1391-1402.
Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Raddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D. Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. Lab On A Chip 2018, 18:3703.
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.Ponath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D. Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nature Communications 2018, 9:5337.
Podoplanin is a negative regulator of Th17 inflammation.Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. JCI Insight 2017, 2.
Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.Goods BA, Hernandez AL, Lowther DE, Lucca LE, Lerner BA, Gunel M, Raddassi K, Coric V, Hafler DA, Love JC. Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme. PloS One 2017, 12:e0181538.
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Frontiers In Immunology 2017, 8:1844.
Solving Immunology?Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC. Solving Immunology? Trends In Immunology 2017, 38:116-127.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.Lucca LE, Hafler DA. Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma. Immunological Reviews 2017, 276:9-25.
TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.Taylor RA, Chang CF, Goods BA, Hammond MD, Grory BM, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. The Journal Of Clinical Investigation 2017, 127:280-292.
Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment.Lucca LE, Hafler DA. Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. The Journal Of Clinical Investigation 2017, 127:1218-1220.
The Human Functional Genomics Project: Understanding Generation of Diversity.Pappalardo JL, Hafler DA. The Human Functional Genomics Project: Understanding Generation of Diversity. Cell 2016, 167:894-896.
CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment.Cao Y, Nylander A, Ramanan S, Goods BA, Ponath G, Zabad R, Chiang VL, Vortmeyer AO, Hafler DA, Pitt D. CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment. Neurology 2016, 86:1553-6.
Power estimation for non-standardized multisite studies.Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BM, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, Hauser SL, Oksenberg JR, Henry RG. Power estimation for non-standardized multisite studies. NeuroImage 2016, 134:281-294.
Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail.Longbrake EE, Hafler DA. Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail. JAMA Neurology 2016, 73:777-8.
Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.Chastre A, Hafler DA, O'Connor KC. Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis. The New England Journal Of Medicine 2016, 374:1495-6.
Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells.Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 196:4040-51.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight 2016, 1.
Multiple sclerosis: genetics, biomarkers, treatments.Axisa PP, Hafler DA. Multiple sclerosis: genetics, biomarkers, treatments. Current Opinion In Neurology 2016, 29:345-53.
The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.Kofler DM, Farkas A, von Bergwelt-Baildon M, Hafler DA. The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations. Current Drug Targets 2016, 17:651-65.
National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence.Oh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG. National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence. Hypertension 2016, 68:281-8.
AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.Kitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease. EMBO Reports 2016, 17:1169-83.
Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli. Science Translational Medicine 2015, 7:291ra93.
Multiple sclerosis-a quiet revolution.Ransohoff RM, Hafler DA, Lucchinetti CF. Multiple sclerosis-a quiet revolution. Nature Reviews. Neurology 2015, 11:134-42.
Thymic selection: to thine own self be true.Kitz A, Hafler DA. Thymic selection: to thine own self be true. Immunity 2015, 42:788-9.
Editorial: T cell regulation by the environment.Hafler DA, Astier AL. Editorial: T cell regulation by the environment. Frontiers In Immunology 2015, 6:229.
Prospects of immune checkpoint modulators in the treatment of glioblastoma.Preusser M, Lim M, Hafler DA, Reardon DA, Sampson JH. Prospects of immune checkpoint modulators in the treatment of glioblastoma. Nature Reviews. Neurology 2015, 11:504-14.
Systems immunology reveals markers of susceptibility to West Nile virus infection.Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clinical And Vaccine Immunology : CVI 2015, 22:6-16.
Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. The Journal Of Infectious Diseases 2015, 211:1174-84.
Sodium-activated macrophages: the salt mine expands.Lucca LE, Hafler DA. Sodium-activated macrophages: the salt mine expands. Cell Research 2015, 25:885-6.
Corrigendum: multiple sclerosis-a quiet revolution.Ransohoff RM, Hafler DA, Lucchinetti CF. Corrigendum: multiple sclerosis-a quiet revolution. Nature Reviews. Neurology 2015, 11:246.
Class II HLA interactions modulate genetic risk for multiple sclerosis.Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TM, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Lar Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J, Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CC, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nature Genetics 2015, 47:1107-1113.
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. The Journal Of Clinical Investigation 2015, 125:4212-22.
Genetic basis of autoimmunity.Marson A, Housley WJ, Hafler DA. Genetic basis of autoimmunity. The Journal Of Clinical Investigation 2015, 125:2234-41.
Monoallelic expression of the human FOXP2 speech gene.Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A. Monoallelic expression of the human FOXP2 speech gene. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112:6848-54.
Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins.Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC. Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins. Frontiers In Immunology 2015, 6:600.
Genetic and epigenetic fine mapping of causal autoimmune disease variants.Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2015, 518:337-43.
TLR7 induces anergy in human CD4(+) T cells.Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA. TLR7 induces anergy in human CD4(+) T cells. Nature Immunology 2015, 16:118-28.
Biomarkers in multiple sclerosis.Housley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clinical Immunology (Orlando, Fla.) 2015, 161:51-8.
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Science Translational Medicine 2015, 7:287ra74.
Role of "Western diet" in inflammatory autoimmune diseases.Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of "Western diet" in inflammatory autoimmune diseases. Current Allergy And Asthma Reports 2014, 14:404.
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014, 40:569-81.
pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics (Oxford, England) 2014, 30:1930-2.
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine 2014, 6:248ra107.
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 2014, 40:477-89.
Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA. Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells. European Journal Of Immunology 2014, 44:2703-2711.
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (New York, N.Y.) 2014, 344:519-23.
TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells.Liu BS, Cao Y, Huizinga TW, Hafler DA, Toes RE. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. European Journal Of Immunology 2014, 44:2121-9.
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. The Journal Of Clinical Investigation 2014, 124:2513-22.
Regulatory T cells in autoimmune neuroinflammation.Kleinewietfeld M, Hafler DA. Regulatory T cells in autoimmune neuroinflammation. Immunological Reviews 2014, 259:231-44.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (New York, N.Y.) 2014, 343:1246980.
Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data.Pyne S, Lee SX, Wang K, Irish J, Tamayo P, Nazaire MD, Duong T, Ng SK, Hafler D, Levy R, Nolan GP, Mesirov J, McLachlan GJ. Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data. PloS One 2014, 9:e100334.
Specific peripheral B cell tolerance defects in patients with multiple sclerosis.Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. The Journal Of Clinical Investigation 2013, 123:2737-41.
Microbial reprogramming inhibits Western diet-associated obesity.Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE. Microbial reprogramming inhibits Western diet-associated obesity. PloS One 2013, 8:e68596.
The plasticity of human Treg and Th17 cells and its role in autoimmunity.Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Seminars In Immunology 2013, 25:305-12.
Immune-mediated disease genetics: the shared basis of pathogenesis.Cotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis. Trends In Immunology 2013, 34:22-6.
Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013, 81:956-63.
The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. Journal Of Immunology (Baltimore, Md. : 1950) 2013, 191:3673-80.
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelcic I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics 2013, 45:1353-60.
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology 2013, 81:1891-9.
Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England) 2013, 19:1726-33.
Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Frontiers In Immunology 2013, 4:358.
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genetics 2013, 9:e1003926.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013, 496:518-22.
PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal Of Autoimmunity 2013, 43:1-9.
Perspective: Deconstructing a disease.Hafler DA. Perspective: Deconstructing a disease. Nature 2012, 484:S6.
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Science Translational Medicine 2012, 4:153ra131.
Regulatory T cells in the central nervous system.Lowther DE, Hafler DA. Regulatory T cells in the central nervous system. Immunological Reviews 2012, 248:156-69.
Prostaglandin E2 affects T cell responses through modulation of CD46 expression.Kickler K, Maltby K, Ni Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL. Prostaglandin E2 affects T cell responses through modulation of CD46 expression. Journal Of Immunology (Baltimore, Md. : 1950) 2012, 188:5303-10.
Induction and molecular signature of pathogenic TH17 cells.Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nature Immunology 2012, 13:991-9.
Unraveling the autoimmune translational research process layer by layer.Blumberg RS, Dittel B, Hafler D, von Herrath M, Nestle FO. Unraveling the autoimmune translational research process layer by layer. Nature Medicine 2012, 18:35-41.
Class II MHC self-antigen presentation in human B and T lymphocytes.Costantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC self-antigen presentation in human B and T lymphocytes. PloS One 2012, 7:e29805.
Multiple sclerosis.Nylander A, Hafler DA. Multiple sclerosis. The Journal Of Clinical Investigation 2012, 122:1180-8.
Polyfunctional responses by human T cells result from sequential release of cytokines.Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109:1607-12.
The TIGIT/CD226 axis regulates human T cell function.Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 axis regulates human T cell function. Journal Of Immunology (Baltimore, Md. : 1950) 2012, 188:3869-75.
Fingolimod for multiple sclerosis.Pelletier D, Hafler DA. Fingolimod for multiple sclerosis. The New England Journal Of Medicine 2012, 366:339-47.
Immunology. An innate role for IL-17.Dominguez-Villar M, Hafler DA. Immunology. An innate role for IL-17. Science (New York, N.Y.) 2011, 332:47-8.
CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186:3317-26.
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JR. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Medicine 2011, 3:3.
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal Of Neuroimmunology 2011, 233:245-8.
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nature Medicine 2011, 17:673-5.
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Annals Of Neurology 2011, 70:897-912.
Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosensors & Bioelectronics 2011, 26:2707-10.
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain : A Journal Of Neurology 2011, 134:534-41.
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187:1039-46.
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL. Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Human Molecular Genetics 2011, 20:3517-24.
The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187:3286-91.
Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PloS One 2011, 6:e24593.
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Martinelli Boneschi F, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox MB, Cozen W, Cree BA, Cross AH, Cusi D, Daly MJ, Davis E, de Bakker PI, Debouverie M, D'hooghe MB, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant SF, Guerini FR, Hakonarson H, Hall P, Hamsten A, Hartung HP, Heard RN, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode AG, Kilpatrick TJ, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott JS, Leone MA, Leppä V, Liljedahl U, Bomfim IL, Lincoln RR, Link J, Liu J, Lorentzen AR, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley JL, Mentch F, Mero IL, Mihalova T, Montalban X, Mottershead J, Myhr KM, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach HL, Ramsay PP, Reunanen M, Reynolds R, Rioux JD, Rodegher M, Roesner S, Rubio JP, Rückert IM, Salvetti M, Salvi E, Santaniello A, Schaefer CA, Schreiber S, Schulze C, Scott RJ, Sellebjerg F, Selmaj KW, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman PM, Smestad C, Sørensen PS, Søndergaard HB, Stankovich J, Strange RC, Sulonen AM, Sundqvist E, Syvänen AC, Taddeo F, Taylor B, Blackwell JM, Tienari P, Bramon E, Tourbah A, Brown MA, Tronczynska E, Casas JP, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus HS, Wang K, Mathew CG, Wason J, Palmer CN, Wichmann HE, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath RC, Yaouanq J, Viswanathan AC, Zhang H, Wood NW, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg JR, Pericak-Vance MA, Haines JL, Olsson T, Hillert J, Ivinson AJ, De Jager PL, Peltonen L, Stewart GJ, Hafler DA, Hauser SL, McVean G, Donnelly P, Compston A. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-9.
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL. Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. Journal Of Neuroimmunology 2011, 233:168-74.
Pervasive sharing of genetic effects in autoimmune disease.Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, Siminovitch KA, van Heel DA, Wijmenga C, Worthington J, Todd JA, Hafler DA, Rich SS, Daly MJ. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genetics 2011, 7:e1002254.
A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD. A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes And Immunity 2011, 12:335-40.
Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis.Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der Pouw Kraan TC, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, Verweij CL. Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis. Genes And Immunity 2011, 12:466-72.
A model for harmonizing flow cytometry in clinical trials.Maecker HT, McCoy JP, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, Di Meglio P, Nestle FO, Peakman M, Villanova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH. A model for harmonizing flow cytometry in clinical trials. Nature Immunology 2010, 11:975-8.
FOXP3+ regulatory T cells in the human immune system.Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nature Reviews. Immunology 2010, 10:490-500.
Variation within DNA repair pathway genes and risk of multiple sclerosis.Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF. Variation within DNA repair pathway genes and risk of multiple sclerosis. American Journal Of Epidemiology 2010, 172:217-24.
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D, Haines J. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics 2010, 42:469-70; author reply 470-1.
Human regulatory T cells in autoimmune diseases.Cvetanovich GL, Hafler DA. Human regulatory T cells in autoimmune diseases. Current Opinion In Immunology 2010, 22:753-60.
Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry.Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. The Journal Of Physical Chemistry. B 2010, 114:585-91.
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving.Han Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab On A Chip 2010, 10:1391-400.
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Human Molecular Genetics 2010, 19:4286-95.
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 2010, 466:243-7.
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.Jakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, Søndergaard HB, Harbo HF, Mero IL, Gabriel SB, Mirel DB, Hauser SL, Kappos L, Polman C, De Jager PL, Hafler DA, Daly MJ, Palotie A, Saarela J, Peltonen L. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. American Journal Of Human Genetics 2010, 86:285-91.
On-chip activation and subsequent detection of individual antigen-specific T cells.Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Analytical Chemistry 2010, 82:473-7.
A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR, Hauser SL. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PloS One 2010, 5:e11296.
T-cells in multiple sclerosis.Severson C, Hafler DA. T-cells in multiple sclerosis. Results And Problems In Cell Differentiation 2010, 51:75-98.
A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Archives Of Neurology 2010, 67:1055-61.
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA, Haines JL. Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Human Genetics 2010, 127:525-35.
RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels.Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 184:685-93.
TGF-beta induces IL-9 production from human Th17 cells.Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185:46-54.
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, Hauser SL, Oksenberg JR, Barcellos LF. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Human Molecular Genetics 2010, 19:2331-40.
A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.Ban M, McCauley JL, Zuvich R, Baker A, Bergamaschi L, Cox M, Kemppinen A, D'Alfonso S, Guerini FR, Lechner-Scott J, Dudbridge F, Wason J, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, Sexton D, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines J, Compston A, Sawcer S. A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. Genes And Immunity 2010, 11:660-4.
A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL. A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. Journal Of Neuroimmunology 2010, 226:192-3.
HLA B*44: protective effects in MS susceptibility and MRI outcome measures.Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL. HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology 2010, 75:634-40.
Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183:4067-76.
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European Journal Of Immunology 2009, 39:2492-501.
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183:4432-9.
Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2.Neilson DE, Adams MD, Orr CM, Schelling DK, Eiben RM, Kerr DS, Anderson J, Bassuk AG, Bye AM, Childs AM, Clarke A, Crow YJ, Di Rocco M, Dohna-Schwake C, Dueckers G, Fasano AE, Gika AD, Gionnis D, Gorman MP, Grattan-Smith PJ, Hackenberg A, Kuster A, Lentschig MG, Lopez-Laso E, Marco EJ, Mastroyianni S, Perrier J, Schmitt-Mechelke T, Servidei S, Skardoutsou A, Uldall P, van der Knaap MS, Goglin KC, Tefft DL, Aubin C, de Jager P, Hafler D, Warman ML. Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. American Journal Of Human Genetics 2009, 84:44-51.
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106:18680-5.
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Human Molecular Genetics 2009, 18:1670-83.
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O'Connor KC. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain : A Journal Of Neurology 2009, 132:3318-28.
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA, Karlson EW. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. The Lancet. Neurology 2009, 8:1111-9.
Engineered interleukin-2 antagonists for the inhibition of regulatory T cells.Liu DV, Maier LM, Hafler DA, Wittrup KD. Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. Journal Of Immunotherapy (Hagerstown, Md. : 1997) 2009, 32:887-94.
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, Eavey RD, Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG, Seidman CE. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nature Genetics 2009, 41:931-5.
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature Genetics 2009, 41:776-82.
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA, Hafler DA. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genetics 2009, 5:e1000322.
The role of the CD58 locus in multiple sclerosis.De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106:5264-9.
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183:945-52.
Automated high-dimensional flow cytometric data analysis.Pyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL, Mesirov JP. Automated high-dimensional flow cytometric data analysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106:8519-24.
Autoimmunity risk alleles in costimulation pathways.Maier LM, Hafler DA. Autoimmunity risk alleles in costimulation pathways. Immunological Reviews 2009, 229:322-36.
IL-17-producing human peripheral regulatory T cells retain suppressive function.Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009, 113:4240-9.
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S, Compston A. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal Of Human Genetics : EJHG 2009, 17:1309-13.
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 182:1541-7.
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP, Gilden D. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Annals Of Neurology 2009, 65:639-49.
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells.De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O'Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA, Weiner HL. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain : A Journal Of Neurology 2008, 131:1701-11.
Lack of TIM-3 immunoregulation in multiple sclerosis.Yang L, Anderson DE, Kuchroo J, Hafler DA. Lack of TIM-3 immunoregulation in multiple sclerosis. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180:4409-14.
Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180:2876-85.
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.Choy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D. Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genetics 2008, 4:e1000287.
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008, 454:350-2.
TIM-4 expressed on APCs induces T cell expansion and survival.Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180:4706-13.
Multiple sclerosis and regulatory T cells.Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. Journal Of Clinical Immunology 2008, 28:697-706.
Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss.Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation 2008, 86:54-62.
Human regulatory T cells and autoimmunity.Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cells and autoimmunity. European Journal Of Immunology 2008, 38:921-4.
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical Immunology (Orlando, Fla.) 2008, 129:10-8.
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal Of Neuroimmunology 2008, 195:140-5.
TIMs: central regulators of immune responses.Hafler DA, Kuchroo V. TIMs: central regulators of immune responses. The Journal Of Experimental Medicine 2008, 205:2699-701.
The developing mosaic of autoimmune disease risk.Maier LM, Hafler DA. The developing mosaic of autoimmune disease risk. Nature Genetics 2008, 40:131-2.
Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A. Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology 2008, 70:1113-8.
CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology 2008, 71:917-24.
Abnormal Tr1 differentiation in multiple sclerosis.Astier AL, Hafler DA. Abnormal Tr1 differentiation in multiple sclerosis. Journal Of Neuroimmunology 2007, 191:70-8.
Polyspecificity of T cell and B cell receptor recognition.Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE. Polyspecificity of T cell and B cell receptor recognition. Seminars In Immunology 2007, 19:216-24.
Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes.Cai G, Hafler DA. Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes. European Journal Of Immunology 2007, 37:602-12.
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nature Genetics 2007, 39:1477-82.
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L. Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 2007, 448:474-9.
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine 2007, 13:211-7.
Allelic variant in CTLA4 alters T cell phosphorylation patterns.Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104:18607-12.
Risk alleles for multiple sclerosis identified by a genomewide study.Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL. Risk alleles for multiple sclerosis identified by a genomewide study. The New England Journal Of Medicine 2007, 357:851-62.
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science (New York, N.Y.) 2007, 318:1141-3.
A second major histocompatibility complex susceptibility locus for multiple sclerosis.Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg JR, Hauser SL, Compston A, Hafler DA, Rioux JD, Sawcer S. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals Of Neurology 2007, 61:228-36.
New therapeutic approaches for multiple sclerosis.De Jager PL, Hafler DA. New therapeutic approaches for multiple sclerosis. Annual Review Of Medicine 2007, 58:417-32.
A local antigen-driven humoral response is present in the inflammatory myopathies.Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O'Connor KC. A local antigen-driven humoral response is present in the inflammatory myopathies. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178:547-56.
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes And Immunity 2007, 8:387-97.
Dysregulated T cell expression of TIM3 in multiple sclerosis.Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal Of Experimental Medicine 2006, 203:1413-8.
Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers.O'Connor KC, Roy SM, Becker CH, Hafler DA, Kantor AB. Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Disease Markers 2006, 22:213-25.
The purification and functional analysis of human CD4+CD25high regulatory T cells.Baecher-Allan CM, Hafler DA. The purification and functional analysis of human CD4+CD25high regulatory T cells. Current Protocols In Immunology / Edited By John E. Coligan ... [et Al.] 2006, Chapter 7:Unit 7.4B.
MHC class II expression identifies functionally distinct human regulatory T cells.Baecher-Allan C, Wolf E, Hafler DA. MHC class II expression identifies functionally distinct human regulatory T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 176:4622-31.
Human regulatory T cells and their role in autoimmune disease.Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunological Reviews 2006, 212:203-16.
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature Genetics 2006, 38:1166-72.
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.Astier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. The Journal Of Clinical Investigation 2006, 116:3252-7.
Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response.Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177:4196-202.
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD. Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. European Journal Of Human Genetics : EJHG 2006, 14:317-21.
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes And Immunity 2006, 7:327-34.
High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model.Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, Altmann DM. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174:1938-46.
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells.Baecher-Allan C, Wolf E, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clinical Immunology (Orlando, Fla.) 2005, 115:10-8.
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005, 435:224-8.
Characterization of in vivo expanded OspA-specific human T-cell clones.Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clinical Immunology (Orlando, Fla.) 2005, 115:313-22.
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175:1974-82.
A high-density screen for linkage in multiple sclerosis.Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. A high-density screen for linkage in multiple sclerosis. American Journal Of Human Genetics 2005, 77:454-67.
Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells.Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175:4458-64.
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nature Genetics 2005, 37:1113-8.
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells.Baecher-Allan CM, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clinical Immunology (Orlando, Fla.) 2005, 117:192; discussion 193.
Applying a new generation of genetic maps to understand human inflammatory disease.Hafler DA, De Jager PL. Applying a new generation of genetic maps to understand human inflammatory disease. Nature Reviews. Immunology 2005, 5:83-91.
Multiple sclerosis.Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunological Reviews 2005, 204:208-31.
T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172:7169-76.
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 2004, 20:563-75.
Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity.Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. The Journal Of Biological Chemistry 2004, 279:910-9.
Suppressor T cells in human diseases.Baecher-Allan C, Hafler DA. Suppressor T cells in human diseases. The Journal Of Experimental Medicine 2004, 200:273-6.
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cellular Immunology 2004, 230:89-98.
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. The Journal Of Experimental Medicine 2004, 199:971-9.
Multiple sclerosis.Hafler DA. Multiple sclerosis. The Journal Of Clinical Investigation 2004, 113:788-94.
Methods for high-density admixture mapping of disease genes.Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. American Journal Of Human Genetics 2004, 74:979-1000.
A high-density admixture map for disease gene discovery in african americans.Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ, Reich D. A high-density admixture map for disease gene discovery in african americans. American Journal Of Human Genetics 2004, 74:1001-13.
Gene expression profiling in MS: what is the clinical relevance?De Jager PL, Hafler DA. Gene expression profiling in MS: what is the clinical relevance? The Lancet. Neurology 2004, 3:269.
Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 173:1689-98.
Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis.Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. European Journal Of Immunology 2004, 34:1839-48.
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Human Molecular Genetics 2004, 13:1943-9.
Human CD4+CD25+ regulatory T cells.Baecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells. Seminars In Immunology 2004, 16:89-98.
Re: GAMES issue study: Are international genetic consortia functional?De Jager PL, Walsh EC, Rioux JD, Hafler DA. Re: GAMES issue study: Are international genetic consortia functional? Journal Of Neuroimmunology 2004, 153:5-6.
Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.Buckle GJ, Höllsberg P, Hafler DA. Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin. Neurology 2003, 60:702-5.
CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls.Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. Journal Of Autoimmunity 2003, 20:71-81.
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. Journal Of Neuroimmunology 2003, 136:140-8.
Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.Lim DG, Slavik JM, Bourcier K, Smith KJ, Hafler DA. Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function. The Journal Of Experimental Medicine 2003, 198:99-109.
Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis.Cao D, Malmström V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. European Journal Of Immunology 2003, 33:215-23.
CTLA4 is associated with susceptibility to multiple sclerosis.Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA, Weinshenker BG. CTLA4 is associated with susceptibility to multiple sclerosis. Journal Of Neuroimmunology 2003, 134:133-41.
Genetic analysis of multiple sclerosis.Walsh EC, Guschwan-McMahon S, Daly MJ, Hafler DA, Rioux JD. Genetic analysis of multiple sclerosis. Journal Of Autoimmunity 2003, 21:111-6.
CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo.Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Foundation Symposium 2003, 252:67-88; discussion 88-91, 106-14.
In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis.Schmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis. Clinical Immunology (Orlando, Fla.) 2003, 106:163-74.
Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells.Lim DG, Höllsberg P, Hafler DA. Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. Cellular Immunology 2002, 217:36-46.
Inhibition of human CD4(+)CD25(+high) regulatory T cell function.Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4(+)CD25(+high) regulatory T cell function. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 169:6210-7.
Degeneracy, as opposed to specificity, in immunotherapy.Hafler DA. Degeneracy, as opposed to specificity, in immunotherapy. The Journal Of Clinical Investigation 2002, 109:581-4.
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes.Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. The Journal Of Clinical Investigation 2002, 109:895-903.
Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis.Gausling R, Trollmo C, Hafler DA. Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis. Clinical Immunology (Orlando, Fla.) 2001, 98:11-7.
Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes.Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166:3201-9.
Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells.Trollmo C, Meyer AL, Steere AC, Hafler DA, Huber BT. Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166:5286-91.
CD4+CD25high regulatory cells in human peripheral blood.Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167:1245-53.
In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG.Ohashi T, Yukitake M, Slavin A, Krieger J, Hafler DA. In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG. Journal Of Neuroimmunology 2001, 118:194-202.
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure.Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. Journal Of Virology 2001, 75:9836-43.
Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state.Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167:5669-77.
Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset.Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA, Hafler DA. Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset. Autoimmunity 2001, 34:247-64.
The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis.O'Connor KC, Bar-Or A, Hafler DA. The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. Journal Of Clinical Immunology 2001, 21:81-92.
Immune tolerance and the nervous system.Anderson DE, Hafler DA. Immune tolerance and the nervous system. Advances In Experimental Medicine And Biology 2001, 490:79-98.
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population.Anderson DE, Bieganowska KD, Bar-Or A, Oliveira EM, Carreno B, Collins M, Hafler DA. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nature Medicine 2000, 6:211-4.
Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis.Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. The Journal Of Clinical Investigation 2000, 105:967-76.
Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes.Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, Strominger JL, Byrne MC. Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97:7411-6.
Ubiquitous pathogens: links between infection and autoimmunity in MS?Hunter SF, Hafler DA. Ubiquitous pathogens: links between infection and autoimmunity in MS? Neurology 2000, 55:164-5.
A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis.Kipp B, Bar-Or A, Gausling R, Oliveira EM, Fruhan SA, Stuart WH, Hafler DA. A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis. European Journal Of Immunology 2000, 30:2092-100.
Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies.Kiefer R, Dangond F, Mueller M, Toyka KV, Hafler DA, Hartung HP. Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies. Journal Of Neurology, Neurosurgery, And Psychiatry 2000, 69:362-8.
Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers.Meyer AL, Trollmo C, Crawford F, Marrack P, Steere AC, Huber BT, Kappler J, Hafler DA. Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97:11433-8.
Antigen-specific therapy for autoimmune disease.Harrison LC, Hafler DA. Antigen-specific therapy for autoimmune disease. Current Opinion In Immunology 2000, 12:704-11.
Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate.Duda PW, Krieger JI, Schmied MC, Balentine C, Hafler DA. Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165:7300-7.
Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope.Lim DG, Bieganowska Bourcier K, Freeman GJ, Hafler DA. Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165:6214-20.
Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.Bieganowska K, Höllsberg P, Buckle GJ, Lim DG, Greten TF, Schneck J, Altman JD, Jacobson S, Ledis SL, Hanchard B, Chin J, Morgan O, Roth PA, Hafler DA. Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. Journal Of Immunology (Baltimore, Md. : 1950) 1999, 162:1765-71.
Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein.Ausubel LJ, Bieganowska KD, Hafler DA. Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein. Cellular Immunology 1999, 193:99-107.
HTLV-I-infected T cells evade the antiproliferative action of IFN-beta.Smith D, Buckle GJ, Hafler DA, Frank DA, Höllsberg P. HTLV-I-infected T cells evade the antiproliferative action of IFN-beta. Virology 1999, 257:314-21.
T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects.Semana G, Gausling R, Jackson RA, Hafler DA. T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects. Journal Of Autoimmunity 1999, 12:259-67.
Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis.Pohl-Koppe A, Logigian EL, Steere AC, Hafler DA. Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. Cellular Immunology 1999, 194:118-23.
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.She JX, Ellis TM, Wilson SB, Wasserfall CH, Marron M, Reimsneider S, Kent SC, Hafler DA, Neuberg DS, Muir A, Strominger JL, Atkinson MA. Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96:8116-9.
Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone.Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL, Hafler DA. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. Journal Of Immunology (Baltimore, Md. : 1950) 1999, 163:2522-9.
The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis.Hafler DA. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis. The Journal Of Clinical Investigation 1999, 104:527-9.
Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d.Kent SC, Hafler DA, Strominger JL, Wilson SB. Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. Human Immunology 1999, 60:1080-9.
Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease.Hohol MJ, Olek MJ, Orav EJ, Stazzone L, Hafler DA, Khoury SJ, Dawson DM, Weiner HL. Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease. Multiple Sclerosis (Houndmills, Basingstoke, England) 1999, 5:403-9.
Autoimmunity. What is the turning point?Flavell RA, Hafler DA. Autoimmunity. What is the turning point? Current Opinion In Immunology 1999, 11:635-7.
The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system.Anderson DE, Sharpe AH, Hafler DA. The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion In Immunology 1999, 11:677-83.
Molecular pathogenesis of multiple sclerosis.Bar-Or A, Oliveira EM, Anderson DE, Hafler DA. Molecular pathogenesis of multiple sclerosis. Journal Of Neuroimmunology 1999, 100:252-9.
Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells.Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR. Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Biochemical And Biophysical Research Communications 1998, 242:648-52.
Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.Pohl-Koppe A, Balashov KE, Steere AC, Logigian EL, Hafler DA. Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. Journal Of Immunology (Baltimore, Md. : 1950) 1998, 160:1804-10.
Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells.Mandelboim O, Kent S, Davis DM, Wilson SB, Okazaki T, Jackson R, Hafler D, Strominger JL. Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95:3798-803.
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.Scholz C, Patton KT, Anderson DE, Freeman GJ, Hafler DA. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. Journal Of Immunology (Baltimore, Md. : 1950) 1998, 160:1532-8.
T helper cell differentiation in multiple sclerosis and autoimmunity.Martin R, Ruddle NH, Reingold S, Hafler DA. T helper cell differentiation in multiple sclerosis and autoimmunity. Immunology Today 1998, 19:495-8.
Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis.Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. Journal Of Neuroimmunology 1998, 91:1-9.
Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis.Pohl-Koppe A, Burchett SK, Thiele EA, Hafler DA. Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. Journal Of Neuroimmunology 1998, 91:19-27.
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 1998, 391:177-81.
Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients.Takashima H, Smith DR, Fukaura H, Khoury SJ, Hafler DA, Weiner HL. Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. Clinical Immunology And Immunopathology 1998, 88:28-34.
Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand.Balashov KE, Smith DR, Khoury SJ, Hafler DA, Weiner HL. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94:599-603.
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 158:2025-34.
Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I.Richardson JH, Höllsberg P, Windhagen A, Child LA, Hafler DA, Lever AM. Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I. Blood 1997, 89:3303-14.
Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease.Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. The Journal Of Experimental Medicine 1997, 185:1585-94.
Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial.Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS, Whitcup SM. Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. American Journal Of Ophthalmology 1997, 123:583-92.
Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity.Dangond F, Windhagen A, Groves CJ, Hafler DA. Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. Journal Of Neuroimmunology 1997, 76:132-8.
Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones.Anderson DE, Ausubel LJ, Krieger J, Höllsberg P, Freeman GJ, Hafler DA. Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159:1669-75.
Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99.Ausubel LJ, Krieger JI, Hafler DA. Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159:2502-12.
Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia.Smith DR, Balashov KE, Hafler DA, Khoury SJ, Weiner HL. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Annals Of Neurology 1997, 42:313-8.
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159:4799-805.
Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P, Hafler DA. Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159:4943-51.
Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients.Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Annals Of The New York Academy Of Sciences 1997, 815:412-22.
Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis.Hafler DA, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Fukaura H. Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Annals Of The New York Academy Of Sciences 1997, 835:120-31.
Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency.Matsui M, Hafler DA, Weiner HL. Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency. Annals Of The New York Academy Of Sciences 1996, 778:398-404.
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. The Journal Of Clinical Investigation 1996, 98:70-7.
IL-12 induces human T cells secreting IL-10 with IFN-gamma.Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. IL-12 induces human T cells secreting IL-10 with IFN-gamma. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157:1127-31.
Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder.Rothenberg ME, Weber WE, Longtine JA, Hafler DA. Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clinical Immunology And Immunopathology 1996, 80:266-72.
Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation.Scholz C, Freeman GJ, Greenfield EA, Hafler DA, Höllsberg P. Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157:2932-8.
TCR usage in human and experimental demyelinating disease.Hafler DA, Saadeh MG, Kuchroo VK, Milford E, Steinman L. TCR usage in human and experimental demyelinating disease. Immunology Today 1996, 17:152-9.
Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells.Scholz C, Hafler DA, Höllsberg P. Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells. Journal Of Neuroscience Research 1996, 45:786-94.
Induction of anergy in CD8 T cells by B cell presentation of antigen.Höllsberg P, Batra V, Dressel A, Hafler DA. Induction of anergy in CD8 T cells by B cell presentation of antigen. Journal Of Immunology (Baltimore, Md. : 1950) 1996, 157:5269-76.
Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones.Ausubel LJ, Kwan CK, Sette A, Kuchroo V, Hafler DA. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93:15317-22.
HTLV-I-induced T-cell activation.Buckle GJ, Hafler DA, Höllsberg P. HTLV-I-induced T-cell activation. Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology : Official Publication Of The International Retrovirology Association 1996, 13 Suppl 1:S107-13.
Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial.Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA, Weiner HL. Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Annals Of The New York Academy Of Sciences 1996, 778:243-50.
Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis.Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Annals Of The New York Academy Of Sciences 1996, 778:251-7.
Role of Th1 and Th2 cells in neurologic disorders.Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA. Role of Th1 and Th2 cells in neurologic disorders. Chemical Immunology 1996, 63:171-86.
Autoimmunity. How to know thy self.Hafler DA, Flavell R. Autoimmunity. How to know thy self. Current Opinion In Immunology 1996, 8:805-7.
Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.Stinissen P, Vandevyver C, Medaer R, Vandegaer L, Nies J, Tuyls L, Hafler DA, Raus J, Zhang J. Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 154:4883-94.
Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.Höllsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92:4036-40.
Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.Balashov KE, Khoury SJ, Hafler DA, Weiner HL. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. The Journal Of Clinical Investigation 1995, 95:2711-9.
Tropical spastic paraparesis on the Caribbean coast of Colombia.Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R, Hafler DA. Tropical spastic paraparesis on the Caribbean coast of Colombia. The American Journal Of Tropical Medicine And Hygiene 1995, 52:155-8.
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML, Hafler DA. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. The Journal Of Experimental Medicine 1995, 182:1985-96.
Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand.Windhagen A, Scholz C, Höllsberg P, Fukaura H, Sette A, Hafler DA. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 1995, 2:373-80.
Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter.McLaurin JA, Hafler DA, Antel JP. Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter. Journal Of The Neurological Sciences 1995, 128:205-11.
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, Kuchroo VK, Hafler DA. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 155:982-92.
Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes.Wucherpfennig KW, Hafler DA, Strominger JL. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92:8896-900.
A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide.Wucherpfennig KW, Hafler DA. A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Annals Of The New York Academy Of Sciences 1995, 756:241-58.
Immunologic mechanisms and therapy in multiple sclerosis.Hafler DA, Weiner HL. Immunologic mechanisms and therapy in multiple sclerosis. Immunological Reviews 1995, 144:75-107.
Therapy for multiple sclerosis.Weiner HL, Hohol MJ, Khoury SJ, Dawson DM, Hafler DA. Therapy for multiple sclerosis. Neurologic Clinics 1995, 13:173-96.
What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis?Höllsberg P, Hafler DA. What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? Annals Of Neurology 1995, 37:143-5.
Antigen-specific therapies for the treatment of autoimmune diseases.Hafler DA, Weiner HL. Antigen-specific therapies for the treatment of autoimmune diseases. Springer Seminars In Immunopathology 1995, 17:61-76.
Antigen specific therapies for the treatment of autoimmune diseases.Hafler DA, Weiner HL. Antigen specific therapies for the treatment of autoimmune diseases. Agents And Actions. Supplements 1995, 47:59-77.
Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease.Hafler DA, Weiner HL. Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. Chemical Immunology 1995, 60:126-49.
Functional three-domain single-chain T-cell receptors.Chung S, Wucherpfennig KW, Friedman SM, Hafler DA, Strominger JL. Functional three-domain single-chain T-cell receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91:12654-8.
Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.Höllsberg P, Ausubel LJ, Hafler DA. Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression. Journal Of Immunology (Baltimore, Md. : 1950) 1994, 153:566-73.
T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. The Journal Of Experimental Medicine 1994, 179:1659-64.
Regional specificity of HTLV-I proviral integration in the human genome.Zoubak S, Richardson JH, Rynditch A, Höllsberg P, Hafler DA, Boeri E, Lever AM, Bernardi G. Regional specificity of HTLV-I proviral integration in the human genome. Gene 1994, 143:155-63.
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. The Journal Of Experimental Medicine 1994, 179:279-90.
Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. The Journal Of Experimental Medicine 1994, 179:973-84.
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. Journal Of Immunology (Baltimore, Md. : 1950) 1994, 152:5581-92.
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (New York, N.Y.) 1994, 265:1237-40.
T cell anergy.LaSalle JM, Hafler DA. T cell anergy. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 1994, 8:601-8.
Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens.Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annual Review Of Immunology 1994, 12:809-37.
Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. The Journal Of Experimental Medicine 1993, 177:425-32.
Increased protein kinase C activity in human memory T cells.Höllsberg P, Melinek J, Benjamin D, Hafler DA. Increased protein kinase C activity in human memory T cells. Cellular Immunology 1993, 149:170-9.
Effects of oral administration of type II collagen on rheumatoid arthritis.Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL. Effects of oral administration of type II collagen on rheumatoid arthritis. Science (New York, N.Y.) 1993, 261:1727-30.
Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group.Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology 1993, 43:910-8.
Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis.Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science (New York, N.Y.) 1993, 259:1321-4.
Biological activity of recombinant human myelin basic protein.Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL, Hafler DA. Biological activity of recombinant human myelin basic protein. Journal Of Neuroimmunology 1993, 44:157-62.
T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen.LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R, Hafler DA. T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. Journal Of Immunology (Baltimore, Md. : 1950) 1993, 151:649-57.
MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination.Zhang J, Medaer R, Stinissen P, Hafler D, Raus J. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science (New York, N.Y.) 1993, 261:1451-4.
Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection.Höllsberg P, Hafler DA. Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. The New England Journal Of Medicine 1993, 328:1173-82.
The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis.Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clinical And Experimental Rheumatology 1993, 11 Suppl 8:S39-40.
Cost effectiveness of thrombolytic therapy with streptokinase in elderly patients with suspected acute myocardial infarction.Krumholz HM, Pasternak RC, Weinstein MC, Friesinger GC, Ridker PM, Tosteson AN, Goldman L. Cost effectiveness of thrombolytic therapy with streptokinase in elderly patients with suspected acute myocardial infarction. The New England Journal Of Medicine 1992, 327:7-13.
T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. The Journal Of Experimental Medicine 1992, 175:993-1002.
Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA. Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. Journal Of Immunology (Baltimore, Md. : 1950) 1992, 148:3256-63.
Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89:4588-92.
Early signaling defects in human T cells anergized by T cell presentation of autoantigen.LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM, Hafler DA. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. The Journal Of Experimental Medicine 1992, 176:177-86.
T cell vaccination in multiple sclerosis: a preliminary report.Hafler DA, Cohen I, Benjamin DS, Weiner HL. T cell vaccination in multiple sclerosis: a preliminary report. Clinical Immunology And Immunopathology 1992, 62:307-13.
T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89:2110-4.
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS, Reiser H. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. Journal Of Immunology (Baltimore, Md. : 1950) 1992, 149:3795-801.
Autoreactive T cells in multiple sclerosis.Zhang J, Weiner HL, Hafler DA. Autoreactive T cells in multiple sclerosis. International Reviews Of Immunology 1992, 9:183-201.
Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis.Hafler DA, Orav J, Gertz R, Stazzone L, Weiner HL. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. Journal Of Neuroimmunology 1991, 32:149-58.
Presentation of autoantigen by human T cells.LaSalle JM, Ota K, Hafler DA. Presentation of autoantigen by human T cells. Journal Of Immunology (Baltimore, Md. : 1950) 1991, 147:774-80.
Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig.Brod SA, al-Sabbagh A, Sobel RA, Hafler DA, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Annals Of Neurology 1991, 29:615-22.
The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle.LaSalle JM, Hafler DA. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cellular Immunology 1991, 138:197-206.
Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA. Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Annals Of Neurology 1991, 29:33-40.
Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.Brod SA, Benjamin D, Hafler DA. Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease. Journal Of Immunology (Baltimore, Md. : 1950) 1991, 147:810-5.
Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis.Hafler DA, Chofflon M, Kurt-Jones E, Weiner HL. Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clinical Immunology And Immunopathology 1991, 58:115-25.
The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis.Hafler DA, Matsui M, Wucherpfennig KW, Ota K, Weiner HL. The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Annals Of The New York Academy Of Sciences 1991, 636:251-65.
Immunotherapy in autoimmune diseases.Miller A, Hafler DA, Weiner HL. Immunotherapy in autoimmune diseases. Current Opinion In Immunology 1991, 3:936-40.
T-cell recognition of myelin basic protein.Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunology Today 1991, 12:277-82.
Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases.Miller A, Hafler DA, Weiner HL. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 1991, 5:2560-6.
T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis.Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990, 346:183-7.
T-T cell interactions are mediated by adhesion molecules.Brod SA, Purvee M, Benjamin D, Hafler DA. T-T cell interactions are mediated by adhesion molecules. European Journal Of Immunology 1990, 20:2259-68.
Frequency analysis of CD4+CD8+ T cells cloned with IL-4.Brod SA, Purvee M, Benjamin D, Hafler DA. Frequency analysis of CD4+CD8+ T cells cloned with IL-4. Cellular Immunology 1990, 125:426-36.
Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein.Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science (New York, N.Y.) 1990, 248:1016-9.
FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation.Dang NH, Hafler DA, Schlossman SF, Breitmeyer JB. FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation. Cellular Immunology 1990, 125:42-57.
Review of immunology.Hafler DA. Review of immunology. Research Publications - Association For Research In Nervous And Mental Disease 1990, 68:23-35.
Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis.Duby AD, Weiner HL, Benjamin DS, Seidman JG, Hafler DA. Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. Journal Of Neuroimmunology 1989, 22:63-8.
MS: a CNS and systemic autoimmune disease.Hafler DA, Weiner HL. MS: a CNS and systemic autoimmune disease. Immunology Today 1989, 10:104-7.
Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells.Chofflon M, González V, Weiner HL, Hafler DA. Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. European Journal Of Immunology 1989, 19:1791-5.
Immunoregulation in multiple sclerosis.Hafler DA, Brod SA, Weiner HL. Immunoregulation in multiple sclerosis. Research In Immunology 1989, 140:233-9; discussion 245-8.
Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid.Chofflon M, Weiner HL, Morimoto C, Hafler DA. Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Annals Of Neurology 1989, 25:494-9.
Lymphokine regulation of CD45R expression on human T cell clones.Brod SA, Rudd CE, Purvee M, Hafler DA. Lymphokine regulation of CD45R expression on human T cell clones. The Journal Of Experimental Medicine 1989, 170:2147-52.
Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression.Hafler DA, Chofflon M, Benjamin D, Dang NH, Breitmeyer J. Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression. Journal Of Immunology (Baltimore, Md. : 1950) 1989, 142:2590-6.
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.Hafler DA, Ritz J, Schlossman SF, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. Journal Of Immunology (Baltimore, Md. : 1950) 1988, 141:131-8.
Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.Carter JL, Hafler DA, Dawson DM, Orav J, Weiner HL. Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients. Neurology 1988, 38:9-14.
Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities.Blue ML, Hafler DA, Daley JF, Levine H, Craig KA, Breitmeyer JB, Schlossman SF. Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities. Journal Of Immunology (Baltimore, Md. : 1950) 1988, 140:376-83.
Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue.Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue. Annals Of The New York Academy Of Sciences 1988, 540:306-8.
The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. Journal Of Immunology (Baltimore, Md. : 1950) 1988, 140:2210-4.
Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody.Borst J, van Dongen JJ, Bolhuis RL, Peters PJ, Hafler DA, de Vries E, van de Griend RJ. Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. The Journal Of Experimental Medicine 1988, 167:1625-44.
Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis.Chofflon M, Weiner HL, Morimoto C, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis. Annals Of Neurology 1988, 24:185-91.
Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL. Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. The Journal Of Experimental Medicine 1988, 167:1313-22.
Immunosuppression with monoclonal antibodies in multiple sclerosis.Hafler DA, Weiner HL. Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology 1988, 38:42-7.
Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis.Chofflon M, Weiner HL, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis. Annals Of The New York Academy Of Sciences 1988, 540:330-2.
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses.Hafler DA, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses. Annals Of The New York Academy Of Sciences 1988, 540:557-9.
Immunotherapy of multiple sclerosis.Weiner HL, Hafler DA. Immunotherapy of multiple sclerosis. Annals Of Neurology 1988, 23:211-22.
Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis.Carter JL, Dawson DM, Hafler DA, Fallis RJ, Stazzone L, Orav J, Weiner HL. Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis. Annals Of The New York Academy Of Sciences 1988, 540:535-6.
Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.Hafler DA, Benjamin DS, Burks J, Weiner HL. Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. Journal Of Immunology (Baltimore, Md. : 1950) 1987, 139:68-72.
Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody.Morimoto C, Hafler DA, Weiner HL, Letvin NL, Hagan M, Daley J, Schlossman SF. Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. The New England Journal Of Medicine 1987, 316:67-72.
Phosphorylation of CD4 and CD8 molecules following T cell triggering.Blue ML, Hafler DA, Craig KA, Levine H, Schlossman SF. Phosphorylation of CD4 and CD8 molecules following T cell triggering. Journal Of Immunology (Baltimore, Md. : 1950) 1987, 139:3949-54.
Secondary immune amplification following live poliovirus immunization in humans.Hafler DA, Fox DA, Benjamin D, Blue ML, Weiner HL. Secondary immune amplification following live poliovirus immunization in humans. Clinical Immunology And Immunopathology 1987, 44:321-8.
Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones.Ang SL, Seidman JG, Peterman GM, Duby AD, Benjamin D, Lee SJ, Hafler DA. Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones. The Journal Of Experimental Medicine 1987, 165:1453-8.
In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis.Hafler DA, Weiner HL. In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis. Annals Of Neurology 1987, 22:89-93.
T cells in multiple sclerosis and inflammatory central nervous system diseases.Hafler DA, Weiner HL. T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunological Reviews 1987, 100:307-32.
Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies.Dawson DM, Carter JL, Hafler DA, Weiner HL. Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies. Rivista Di Neurologia 1987, 57:88-91.
Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics.Hafler DA, Johnson D, Kelly JJ, Panitch H, Kyle R, Weiner HL. Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics. Neurology 1986, 36:75-8.
Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis.Johnson D, Hafler DA, Fallis RJ, Lees MB, Brady RO, Quarles RH, Weiner HL. Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. Journal Of Neuroimmunology 1986, 13:99-108.
Antigen reactive memory T cells are defined by Ta1.Hafler DA, Fox DA, Benjamin D, Weiner HL. Antigen reactive memory T cells are defined by Ta1. Journal Of Immunology (Baltimore, Md. : 1950) 1986, 137:414-8.
Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, Weiner HL. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology 1986, 36:777-84.
Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis.Hafler DA, Buchsbaum M, Johnson D, Weiner HL. Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis. Annals Of Neurology 1985, 18:451-8.
Decreased autologous mixed lymphocyte reaction in multiple sclerosis.Hafler DA, Buchsbaum M, Weiner HL. Decreased autologous mixed lymphocyte reaction in multiple sclerosis. Journal Of Neuroimmunology 1985, 9:339-47.
In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. The New England Journal Of Medicine 1985, 312:1405-11.
Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases.Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL. Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clinical Immunology And Immunopathology 1985, 37:163-71.
The use of cyclophosphamide in the treatment of multiple sclerosis.Weiner HL, Hauser SL, Hafler DA, Fallis RJ, Lehrich JR, Dawson DM. The use of cyclophosphamide in the treatment of multiple sclerosis. Annals Of The New York Academy Of Sciences 1984, 436:373-81.
Altered blood T-cell subsets in patients with multiple sclerosis.Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL. Altered blood T-cell subsets in patients with multiple sclerosis. Journal Of Neuroimmunology 1984, 6:115-21.
Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes.Tardieu M, Powers ML, Hafler DA, Hauser SL, Weiner HL. Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. European Journal Of Immunology 1984, 14:561-5.
T cell subsets in patients with multiple sclerosis. An overview.Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL. T cell subsets in patients with multiple sclerosis. An overview. Annals Of The New York Academy Of Sciences 1984, 436:281-93.
Embarrassment as the aura of a complex partial seizure.Devinsky O, Hafler DA, Victor J. Embarrassment as the aura of a complex partial seizure. Neurology 1982, 32:1284-5.
Prolonged benzodiazepine coma.Ruff RL, Kutt H, Hafler D. Prolonged benzodiazepine coma. New York State Journal Of Medicine 1981, 81:776-7.
Spinal subarachnoid hematoma: a hazard of lumbar puncture resulting in reversible paraplegia.Brem SS, Hafler DA, Van Uitert RL, Ruff RL, Reichert WH. Spinal subarachnoid hematoma: a hazard of lumbar puncture resulting in reversible paraplegia. The New England Journal Of Medicine 1981, 304:1020-1.
Integrative Analysis of 111 Reference Genomes.Roadmap Epigenomics Consortium. Integrative Analysis of 111 Reference Genomes. Nature. 2015 Feb 19;518(7539):317-30. doi: 10.1038/nature14248. PMID: 25693563
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Sumida TS, Dulberg S, Schupp J, Stillwell HA, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. BioRxiv : The Preprint Server For Biology 2020.
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis.Pompura SL, Wagner A, Kitz A, Laperche J, Yosef N, Dominguez-Villar M, Hafler D. Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis. The Journal Of Clinical Investigation 2021, 131.
Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Sparks R, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity. MedRxiv : The Preprint Server For Health Sciences 2021.
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells.Lucca LE, Axisa PP, Lu B, Harnett B, Jessel S, Zhang L, Raddassi K, Zhang L, Olino K, Clune J, Singer M, Kluger HM, Hafler DA. Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells. The Journal Of Experimental Medicine 2021, 218.
Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells.Tran TT, Rane CK, Zito CR, Weiss SA, Jessel S, Lucca L, Lu BY, Oria VO, Adeniran A, Chiang VL, Omay SB, Hafler DA, Kluger HM, Jilaveanu LB. Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells. Cancers 2021, 13.
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity 2021, 54:1083-1095.e7.
Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19.Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19. Journal Of Immunology (Baltimore, Md. : 1950) 2021.
NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data.He L, Davila-Velderrain J, Sumida TS, Hafler DA, Kellis M, Kulminski AM. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications Biology 2021, 4:629.
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells.Jiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells. JCI Insight 2021, 6.
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. Research Square 2021.
23Na imaging: Worth its salt for understanding multiple sclerosis.Longbrake EE, Hafler DA. 23Na imaging: Worth its salt for understanding multiple sclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118.

Clinical Trials

Conditions	Study Title
Diseases of the Nervous System	Evaluating the Immune Response to COVID-19 Vaccination in B-cell Depleted Patients
Diseases of the Nervous System; HIV/AIDS; Infectious Diseases; COVID-19 Inpatient; COVID-19 Outpatient	HIV Associated Reservoirs and Comorbidities (The HARC Plus Study)
Diseases of the Respiratory Systems; COVID-19 Inpatient; COVID-19 Outpatient	A Study Tracking Health Care Workers Exposed to COVID-19
Phase I	A Phase Ib Study of Nivolumab in Patients With Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)
Genetics - Adult; Immune System	The PhenoGenetic Project
Diseases of the Nervous System	Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS)

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