Research & Publications
I am evaluating the role of an inflammatory protein called macrophage migration inhibitory factor (MIF) in autoimmune hepatitis and its ability to predict disease severity, response to therapy, and disease relapse. I am also investigating the potential role of MIF as a chemical mediator between psychological stress and liver inflammation autoimmune hepatitis.
I am evaluating mechanisms of disease and therapies for the treatment of Primary Sclerosing Cholangitis including the development of novel bile-derived organoids for the study of this disease.
Extensive Research Description
I am investigating the role of macrophage migration inhibitory factor (MIF) in autoimmune hepatitis. Active studies involve serial measurement of serum MIF and its soluble receptor (CD74) in the blood of patients with autoimmune hepatitis, to evaluate if these proteins can serve as biomarkers of disease activity.
I am evaluating cellular mechanisms of the release of the CD74 protein and its neutralizing activity on the cytokine MIF.
I am investigating the role of MIF in the pathophysiology of autoimmune hepatitis in animal models of disease.
A study of the role of macrophage migration inhibitory factor (MIF) in autoimmune hepatitis, through clinical and translational investigations.
I am evaluating potential new therapies for Primary Sclerosing Cholangitis (PSC) including all-trans retinoic acid and the development of bile-derived organoids for translational studies in this disease.
Autoimmune Diseases; Cystic Fibrosis; Hepatitis; Liver; Liver Diseases
Public Health Interests
- Now you see it, now you don’t.Plotkin E, Assis DN, Boyer JL. Hepatology. 2013;58:446-447 (Case Report)
- Chapter 43: Primary and Secondary Sclerosing CholangitisBowlus CL, Assis DN, Goldberg DS. Zakim and Boyer’s Hepatology: A Textbook of Liver Disease. Elsevier (7th Edition).
- The Immunopathogenesis of Autoimmune HepatitisClinical Liver Disease (in press)