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David Schoenfeld, MD, PhD
Clinical Fellow; Heme-Onc Medicine Fellow, Medical Oncology
Contact Information
David Schoenfeld, MD, PhD
Email
david.schoenfeld@yale.edu
Research & Publications
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Coauthors
Adebowale Adeniran
Bauer Sumpio
David Rimm
Harriet Kluger
Joseph Madri
Michael Hurwitz
Sandra Canosa
Selected Publications
Location matters: LAG3 levels are lower in renal cell carcinoma metastatic sites compared to primary tumors, and expression at metastatic sites only may have prognostic importance
Schoenfeld D, Merkin R, Moutafi M, Martinez S, Adeniran A, Kumar D, Jilaveanu L, Hurwitz M, Rimm D, Kluger H. Location matters: LAG3 levels are lower in renal cell carcinoma metastatic sites compared to primary tumors, and expression at metastatic sites only may have prognostic importance Frontiers In Oncology 2022, 12: 990367.
PMID: 36313654
,
PMCID: PMC9608089
,
DOI: 10.3389/fonc.2022.990367
.
Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinomaPBRM1 loss increases H3K4me3 marks and expression of ALDH1A1
Schoenfeld D
, Zhou R, Zairis S, Su W, Steinbach N, Mathur D, Bansal A, Zachem A, Tavarez B, Hasson D, Bernstein E, Rabadan R, Parsons R. Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinomaPBRM1 loss increases H3K4me3 marks and expression of ALDH1A1 Molecular Cancer Research 2022, 20: 1193-1207.
PMID: 35412614
,
PMCID: PMC9357026
,
DOI: 10.1158/1541-7786.mcr-21-1039
.
Abstract A24: PBRM1 alteration in clear cell renal cell carcinoma increases tumorigenicity through ALDH1A1 upregulation
Schoenfeld D
, Su W, Zairis S, Mathur D, Rabadan R, Parsons R. Abstract A24: PBRM1 alteration in clear cell renal cell carcinoma increases tumorigenicity through ALDH1A1 upregulation Cancer Research 2016, 76: a24-a24.
DOI: 10.1158/1538-7445.chromepi15-a24
.
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion
Mense SM, Barrows D, Hodakoski C, Steinbach N,
Schoenfeld D
, Su W, Hopkins BD, Su T, Fine B, Hibshoosh H, Parsons R. PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion Science Signaling 2015, 8: ra32.
PMID: 25829446
,
PMCID: PMC4874664
,
DOI: 10.1126/scisignal.2005840
.
Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells
Brown-Endres L, Schoenfeld D, Tian F, Kim HG, Namba T, Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW. Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells Cancer Research 2012, 72: 2373-2382.
PMID: 22549949
,
PMCID: PMC3349239
,
DOI: 10.1158/0008-5472.can-11-3369
.
PECAM-1 Affects GSK-3β-Mediated β-Catenin Phosphorylation and Degradation
Biswas P, Canosa S,
Schoenfeld D
,
Schoenfeld J
, Li P, Cheas LC, Zhang J, Cordova A, Sumpio B, Madri JA. PECAM-1 Affects GSK-3β-Mediated β-Catenin Phosphorylation and Degradation American Journal Of Pathology 2006, 169: 314-324.
PMID: 16816383
,
PMCID: PMC1698776
,
DOI: 10.2353/ajpath.2006.051112
.
Identification of the regions of PECAM-1 involved in β- and γ-catenin associations
Biswas P, Zhang J,
Schoenfeld JD
,
Schoenfeld D
, Gratzinger D, Canosa S, Madri JA. Identification of the regions of PECAM-1 involved in β- and γ-catenin associations Biochemical And Biophysical Research Communications 2005, 329: 1225-1233.
PMID: 15766557
,
DOI: 10.1016/j.bbrc.2005.02.095
.
PECAM-1 promotes β-catenin accumulation and stimulates endothelial cell proliferation
Biswas P, Canosa S,
Schoenfeld J
,
Schoenfeld D
, Tucker A, Madri JA. PECAM-1 promotes β-catenin accumulation and stimulates endothelial cell proliferation Biochemical And Biophysical Research Communications 2003, 303: 212-218.
PMID: 12646189
,
DOI: 10.1016/s0006-291x(03)00313-9
.
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