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David Peaper, MD, PhD

Associate Professor of Laboratory Medicine; Director, Clinical Microbiology Laboratory, YNHH; Director, Virology Reference Laboratory, VACT; Director, Medical Microbiology Fellowship Program

Contact Information

David Peaper, MD, PhD

Office Location

Mailing Address

  • Laboratory Medicine

    789 Howard Avenue, PO Box 208035

    New Haven, CT 06520-8035

    United States

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Research Summary

I am interested in the interaction between basic and clinical sciences and using the tools and resources of the clinical and basic science research communities to further our understanding of the mechanisms of organism pathogenesis and improving diagnostics available for the more rapid and/or accurate identification of infectious diseases. I collaborate with Yale scientists to increase the clinical relevance of research projects as well as identify current gaps in diagnostic testing where advanced methods may improve patient care.

I also have an interest in both assessing the outcomes of laboratory interventions and testing practices on patient care and identifying ways to streamline laboratory practices to improve our ability to provide test results. We have identified areas for improvement for the implementation of rapid respiratory virus testing and its impact on antibiotic overuse. Additionally, working with others at Yale and YNHH, we have studied a number of interventions in practices to improve test utilization and decrease rates of hospital acquired infections.

Coauthors

Research Interests

Bacterial Infections; Influenza, Human; Clostridioides difficile; Clinical Laboratory Techniques; Organisms

Selected Publications

  • Nocardia veterana infections: case report and systematic reviewRadcliffe C, Peaper D, Grant M. Nocardia veterana infections: case report and systematic review New Microbes And New Infections 2020, 39: 100833. PMID: 33456780, PMCID: PMC7797559, DOI: 10.1016/j.nmni.2020.100833.
  • Co-Culture of Acinetobacter calcoaceticus-baumannii complex and Staphylococcus saprophyticus Supports Simple Point Contamination Model in Recent Cases of Transfusion-Related SepsisKerantzas C, Merwede J, Snyder E, Hendrickson J, Tormey C, Kazmierczak B, Peaper D. Co-Culture of Acinetobacter calcoaceticus-baumannii complex and Staphylococcus saprophyticus Supports Simple Point Contamination Model in Recent Cases of Transfusion-Related Sepsis American Journal Of Clinical Pathology 2020, 154: s14-s14. DOI: 10.1093/ajcp/aqaa137.025.
  • Outcomes of Patients With Hospital-Acquired InfluenzaCampbell M, James A, Fairweather I, Rivera-Vinas J, Kaslow R, Landry M, Peaper D, Martinello R. Outcomes of Patients With Hospital-Acquired Influenza Infection Control And Hospital Epidemiology 2020, 41: s340-s340. DOI: 10.1017/ice.2020.951.
  • Performance of the Procalcitonin Test in Diagnosing Pneumonia in Real-World PracticeAyala-Lopez N, Ghaedi M, Peaper D, Harb R. Performance of the Procalcitonin Test in Diagnosing Pneumonia in Real-World Practice American Journal Of Clinical Pathology 2019, 152: s36-s36. DOI: 10.1093/ajcp/aqz112.069.
  • Procalcitonin's performance in diagnosing pneumonia in real-world practiceAyala-Lopez N, Ghaedi M, Peaper D, Harb R. Procalcitonin's performance in diagnosing pneumonia in real-world practice Clinica Chimica Acta 2019, 493: s557. DOI: 10.1016/j.cca.2019.03.1170.
  • 1797. Combining Rapid Diagnostics With Pharmacy Resident-Led Antimicrobial Stewardship to Optimize Outcomes for Bacteremia With Methicillin-Resistant S. aureus (MRSA-B), Methicillin-Susceptible S. aureus (MSSA-B), and Coagulase-Negative Staphylococcus (CoNS) at Yale New Haven Hospital (YNHH)Bejou N, McManus D, Peaper D, Topal J. 1797. Combining Rapid Diagnostics With Pharmacy Resident-Led Antimicrobial Stewardship to Optimize Outcomes for Bacteremia With Methicillin-Resistant S. aureus (MRSA-B), Methicillin-Susceptible S. aureus (MSSA-B), and Coagulase-Negative Staphylococcus (CoNS) at Yale New Haven Hospital (YNHH) Open Forum Infectious Diseases 2018, 5: s509-s509. PMCID: PMC6254813, DOI: 10.1093/ofid/ofy210.1453.
  • Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial InfectionsPruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin S, Aronson PL, Collaborative F, Nigrovic L, Browning W, Mitchell C, Peaper D, Feldman E. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections The Journal Of Pediatrics 2018, 204: 177-182.e1. PMID: 30297292, PMCID: PMC6309646, DOI: 10.1016/j.jpeds.2018.08.066.
  • The Development and Implementation of a Novel Electronic Consult (E-Consult) System by a Laboratory Medicine Service: Experience From the First 2 Years of UseStendahl K, Siddon A, Peaper D, Hauser R, Campbell S, Tormey C. The Development and Implementation of a Novel Electronic Consult (E-Consult) System by a Laboratory Medicine Service: Experience From the First 2 Years of Use American Journal Of Clinical Pathology 2018, 150: s134-s134. DOI: 10.1093/ajcp/aqy103.320.
  • Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency DepartmentsWoll C, Neuman MI, Pruitt CM, Wang ME, Shapiro ED, Shah SS, McCulloh RJ, Nigrovic LE, Desai S, DePorre AG, Leazer RC, Marble RD, Balamuth F, Feldman EA, Sartori LF, Browning WL, Aronson PL, Collaborative F, Alpern E, Hayes K, Lee B, Lumb C, Mitchell C, Peaper D, Rooholamini S, Shin S, Williams D. Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments The Journal Of Pediatrics 2018, 200: 210-217.e1. PMID: 29784512, PMCID: PMC6109608, DOI: 10.1016/j.jpeds.2018.04.033.
  • 305 “Enhanced” Antibiogram: Emerging Data Management Technology for Curation and Visual Presentation of Antimicrobial Resistance PatternsDurant T, Schulz W, Peaper D. 305 “Enhanced” Antibiogram: Emerging Data Management Technology for Curation and Visual Presentation of Antimicrobial Resistance Patterns American Journal Of Clinical Pathology 2018, 149: s130-s130. DOI: 10.1093/ajcp/aqx124.304.
  • Bacterial Identification using 16S rRNA Gene Sequencing in a University Teaching HospitalPoonawala H, Peaper D. Bacterial Identification using 16S rRNA Gene Sequencing in a University Teaching Hospital Open Forum Infectious Diseases 2017, 4: s600-s600. PMCID: PMC5630713, DOI: 10.1093/ofid/ofx163.1576.
  • Identifying Educational Opportunities from Phonecalls to the Microbiology LaboratoryPoonawala H, Sebastian C, Peaper D. Identifying Educational Opportunities from Phonecalls to the Microbiology Laboratory Open Forum Infectious Diseases 2017, 4: s442-s443. PMCID: PMC5631460, DOI: 10.1093/ofid/ofx163.1123.
  • Histoplasmosis in a Nonendemic Area: An Often Unrecognized DiseaseAzar M, Assi R, Ogbuagu O, Peaper D, Zhang X, Hage C, Wheat L, Malinis M. Histoplasmosis in a Nonendemic Area: An Often Unrecognized Disease Open Forum Infectious Diseases 2016, 3: 1614. DOI: 10.1093/ofid/ofw172.1314.
  • Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult OutpatientsGreen DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR. Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients Journal Of Clinical Microbiology 2016, 54: 2950-2955. PMID: 27654334, PMCID: PMC5121384, DOI: 10.1128/jcm.01579-16.
  • Logistic Regression Modeling: Statistically Driven Stewardship of Anaplasma Polymerase Chain Reaction Testing by Complete Blood Count and Basic Metabolic ProfileDurant T, Peaper D. Logistic Regression Modeling: Statistically Driven Stewardship of Anaplasma Polymerase Chain Reaction Testing by Complete Blood Count and Basic Metabolic Profile American Journal Of Clinical Pathology 2016, 146 DOI: 10.1093/ajcp/aqw155.002.
  • Is Ceftriaxone (CRO) Effective in Treating Ceftriaxone Resistant (CRO-R) Escherichia coli Urinary Tract Infections?Lee P, Hung W, Peaper D, Topal J. Is Ceftriaxone (CRO) Effective in Treating Ceftriaxone Resistant (CRO-R) Escherichia coli Urinary Tract Infections? Open Forum Infectious Diseases 2015, 2: 1180. DOI: 10.1093/ofid/ofv133.892.
  • The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in childrenMurray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.
  • Clinical and Molecular Epidemiology of Pretransplant Vancomycin-Resistant Enterococci (VRE) Colonization Among Patients Who Undergo Liver Transplantation.Banach D, Peaper D, Emre S, Fortune B, Dembry L. Clinical and Molecular Epidemiology of Pretransplant Vancomycin-Resistant Enterococci (VRE) Colonization Among Patients Who Undergo Liver Transplantation. Transplantation 2014, 98: 769. DOI: 10.1097/00007890-201407151-02627.
  • Rapid Diagnosis of Influenza State of the ArtPeaper DR, Landry ML. Rapid Diagnosis of Influenza State of the Art Clinics In Laboratory Medicine 2014, 34: 365-385. PMID: 24856533, PMCID: PMC7172071, DOI: 10.1016/j.cll.2014.02.009.
  • Use of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass SpectrometryKulkarni MV, Zurita AN, Pyka JS, Murray TS, Hodsdon ME, Peaper DR. Use of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass Spectrometry Journal Of Clinical Microbiology 2014, 52: 2500-2505. PMID: 24789180, PMCID: PMC4097713, DOI: 10.1128/jcm.00547-14.
  • Response to Mold Contamination of Intravenous Magnesium Sulfate Produced by a Compounding PharmacyBoyce JM, Lee L, Topal J, Peaper DR, Balcezak T. Response to Mold Contamination of Intravenous Magnesium Sulfate Produced by a Compounding Pharmacy JAMA Internal Medicine 2014, 174: 630-631. PMID: 24493036, DOI: 10.1001/jamainternmed.2013.13772.
  • The redox activity of ERp57 is not essential for its functions in MHC class I peptide loadingPeaper DR, Cresswell P. The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 10477-10482. PMID: 18650385, PMCID: PMC2483232, DOI: 10.1073/pnas.0805044105.
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