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Daniela Tirziu, PhD

Research Scientist; Associate Director of Academic Research, Yale Cardiovascular Research Group

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Daniela Tirziu, PhD

Research Summary

My clinical research is focused on the design, reporting and regulatory documentations for interventional cardiovascular device trials, including First-in-Human, CE Mark, IDE/IND Phase III and IV trials and post marketing studies in the US and worldwide.

Basic science research had been focused on growth regulatory mechanisms generated by the endothelium-to-cardiomyocytes communication through the endothelium-released nitric oxide, Gi /Gq protein signaling and microRNAs.

Specialized Terms: Ischemic Heart Disease; Medical Devices; Clinical Trial; Endothelium-Cardiomyocytes Communication; Myocardial Hypertrophy; Nitric Oxide; Gi/Gq Signaling; microRNAs.

Extensive Research Description

Dr. Tirziu has made substantial contributions to scientifically sound clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices during transcatheter heart procedures.

On the basic science front, findings from Dr. Tirziu's laboratory showed that stimulation of angiogenesis in the heart promotes cardiomyocyte growth and myocardial hypertrophy through a nitric oxide (NO)-dependent mechanism involving the degradation of regulator of G protein signaling type 4 (RGS4) and de-repression of the Gβγ/PI3Kγ/Akt/mTORC1 pathway with the up-regulation of miR-182 and miR-146b expression in cardiomyocytes.

Coauthors

Research Interests

Cardiovascular Diseases; Cell Communication; Endothelium, Vascular; Heart Diseases; Heart Failure; Clinical Trial; MicroRNAs; Endothelium-Dependent Relaxing Factors; Gene Regulatory Networks; Publication Characteristics

Selected Publications

  • Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study).Shishehbor MH, Zeller T, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh SA, Kashyap VS, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi KA, Wali AU, Lansky AJ. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study). Circulation 2022, 145: 1645-1654. PMID: 35377157, DOI: 10.1161/CIRCULATIONAHA.122.059646.
  • Outcomes Among Patients with Chronic Critical Limb Ischemia with No-Revascularization Option: Systematic Review and Meta-Analysis.Ghare MI, Pietras C, Tirziu D, Parise H, White R, Altin E, Nagpal S, Lansky A. Outcomes Among Patients with Chronic Critical Limb Ischemia with No-Revascularization Option: Systematic Review and Meta-Analysis. J Crit Limb Ischem. 2021;1(3):E85-E92.
  • Long term outcomes of ultrathin versus standard thickness second-generation drug eluting stents: Meta-analysis of randomized trials.Hussain Y, Gaston S, Kluger J, Shah T, Yang Y, Tirziu D, Lansky A. Long term outcomes of ultrathin versus standard thickness second-generation drug eluting stents: Meta-analysis of randomized trials. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2022, 99: 563-574. PMID: 34236755, DOI: 10.1002/ccd.29866.
  • Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction.Shah T, Haimi I, Yang Y, Gaston S, Taoutel R, Mehta S, Lee HJ, Zambahari R, Baumbach A, Henry TD, Grines CL, Lansky A, Tirziu D. Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2021, 147: 23-32. PMID: 33640366, DOI: 10.1016/j.amjcard.2021.02.015.
  • Sex-Specific Outcomes in Cardiovascular Device Evaluations.Ghare MI, Tirziu D, Abbott JD, Altin E, Yang Y, Ng V, Grines C, Lansky A. Sex-Specific Outcomes in Cardiovascular Device Evaluations. Journal Of Women's Health (2002) 2020, 29: 1246-1255. PMID: 32543268, DOI: 10.1089/jwh.2019.8068.
  • First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions.Garcia-Lithgow C, Tirziu D, Zhou S, Bouras G, Shah T, Grubman D, Javier JJ, Mustapha JA, Abizaid A, Lansky AJ. First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions. JACC. Cardiovascular Interventions 2019, 12: 2568-2570. PMID: 31857033, DOI: 10.1016/j.jcin.2019.08.044.
  • Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure.Pfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D. Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure. Scientific Reports 2019, 9: 5791. PMID: 30962467, PMCID: PMC6453892, DOI: 10.1038/s41598-019-42113-0.
  • Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization.Memi F, Tirziu D, Papangeli I. Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization. Journal Of Visualized Experiments : JoVE 2018 PMID: 30272664, PMCID: PMC6235194, DOI: 10.3791/57920.
  • Cardiac Hypertrophy: Signaling and Cellular CrosstalkTirziu D., Cardiac Hypertrophy: Signaling and Cellular Crosstalk, 2018. In: Vasan R., Sawyer, D.(eds.) The Encyclopedia of Cardiovascular Research and Medicine, vol.[1], pp. 434-450. Oxford: Elsevier
  • miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart.Li N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J, Mikush N, Larrivée B, Eichmann A, Chun HJ, Young LH, Tirziu D. miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. Scientific Reports 2016, 6: 21228. PMID: 26888314, PMCID: PMC4758045, DOI: 10.1038/srep21228.
  • Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease.Stacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ. Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease. Circulation. Cardiovascular Imaging 2014, 7: 92-9. PMID: 24170237, PMCID: PMC3929970, DOI: 10.1161/CIRCIMAGING.113.000884.
  • Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy.Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Journal Of Visualized Experiments : JoVE 2014, e51666. PMID: 24998400, PMCID: PMC4209952, DOI: 10.3791/51666.
  • NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. The Journal Of Clinical Investigation 2013, 123: 1718-31. PMID: 23454748, PMCID: PMC3613910, DOI: 10.1172/JCI65112.
  • Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation 2012, 126: 2589-600. PMID: 23091063, PMCID: PMC3514045, DOI: 10.1161/CIRCULATIONAHA.112.119321.
  • Cell communications in the heart.Tirziu D, Giordano FJ, Simons M. Cell communications in the heart. Circulation 2010, 122: 928-37. PMID: 20805439, PMCID: PMC2941440, DOI: 10.1161/CIRCULATIONAHA.108.847731.
  • Endothelium as master regulator of organ development and growth.Tirziu D, Simons M. Endothelium as master regulator of organ development and growth. Vascular Pharmacology 2009, 50: 1-7. PMID: 18804188, PMCID: PMC2630387, DOI: 10.1016/j.vph.2008.08.003.
  • Endothelium-driven myocardial growth or nitric oxide at the crossroads.Tirziu D, Simons M. Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends In Cardiovascular Medicine 2008, 18: 299-305. PMID: 19345317, PMCID: PMC2692333, DOI: 10.1016/j.tcm.2009.01.002.
  • Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice.Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. The Journal Of Clinical Investigation 2007, 117: 3188-97. PMID: 17975666, PMCID: PMC2045601, DOI: 10.1172/JCI32024.
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