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Csaba Leranth, MD, PhD

Professor of Obstetrics, Gynecology, and Reproductive Sciences and of Neuroscience

Contact Information

Csaba Leranth, MD, PhD

Mailing Address

  • Obstetrics, Gynecology & Reproductive Sciences

    333 Cedar Street

    New Haven, CT 06510-

    United States

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Research Summary

Positive gonadal hormonal and negative bisphenol A effects on brain areas involved mnemonic functions (hippocampus and prefrontal cortex) of females and males

Specialized Terms: Positive gonadal hormonal negative bisphenol A effects

Extensive Research Description

Bisphenol A effect on the non-human primate brain.

Gene therapy of primate model of Parkinsons disease.

Morphological changes in the primate brain in PCP model of schizophrenia.

Coauthors

Research Interests

Anatomy; Endocrine System; Gynecology; Nervous System; Neurobiology

Research Image

Effect of Bisphenol A on the spine synapses of the prefrontal cortex of non-human primates. Bisphenol A dministration results in a loss of spine synapses (panel b) compared to controls (panel a).

Selected Publications

  • Bisphenol A interferes with synaptic remodeling.Hajszan T, Leranth C. Bisphenol A interferes with synaptic remodeling. Frontiers In Neuroendocrinology 2010, 31: 519-30. PMID: 20609373, PMCID: PMC2964437, DOI: 10.1016/j.yfrne.2010.06.004.
  • Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression.Hajszan T, Dow A, Warner-Schmidt JL, Szigeti-Buck K, Sallam NL, Parducz A, Leranth C, Duman RS. Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression. Biological Psychiatry 2009, 65: 392-400. PMID: 19006787, PMCID: PMC2663388, DOI: 10.1016/j.biopsych.2008.09.031.
  • Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates.Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-91. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.
  • Bisphenol A prevents the synaptogenic response to testosterone in the brain of adult male rats.Leranth C, Szigeti-Buck K, Maclusky NJ, Hajszan T. Bisphenol A prevents the synaptogenic response to testosterone in the brain of adult male rats. Endocrinology 2008, 149: 988-94. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.
  • Sex steroids and the dentate gyrus.Hajszan T, Milner TA, Leranth C. Sex steroids and the dentate gyrus. Progress In Brain Research 2007, 163: 399-415. PMID: 17765731, PMCID: PMC1964752, DOI: 10.1016/S0079-6123(07)63023-4.
  • Extrinsic afferent systems to the dentate gyrus.Leranth C, Hajszan T. Extrinsic afferent systems to the dentate gyrus. Progress In Brain Research 2007, 163: 63-84. PMID: 17765712, PMCID: PMC1989689, DOI: 10.1016/S0079-6123(07)63004-0.
  • Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex.Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse (New York, N.Y.) 2007, 61: 862-5. PMID: 17630673, DOI: 10.1002/syn.20430.
  • Effects of androgens and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats.Hajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C. Effects of androgens and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats. Endocrinology 2007, 148: 1963-7. PMID: 17317772, PMCID: PMC2128740, DOI: 10.1210/en.2006-1626.
  • Androgen effects on hippocampal CA1 spine synapse numbers are retained in Tfm male rats with defective androgen receptors.MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen effects on hippocampal CA1 spine synapse numbers are retained in Tfm male rats with defective androgen receptors. Endocrinology 2006, 147: 2392-8. PMID: 16439462, DOI: 10.1210/en.2005-0673.
  • The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis.MacLusky NJ, Hajszan T, Leranth C. The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis. Environmental Health Perspectives 2005, 113: 675-9. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.
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