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Craig Roy, PhD

Waldemar Von Zedtwitz Professor of Microbial Pathogenesis and of Immunobiology and Director of Biological and Biomedical Sciences (BBS); Vice-Chair, Department of Microbial Pathogenesis

Contact Information

Craig Roy, PhD

Mailing Address

  • Microbial Pathogenesis

    Department of Microbial Pathogenesis, 295 Congress Avenue, BCMM 354B

    New Haven, CT, 06536-0812

    United States

Research Summary

The focus of our research is to understand the molecular and cellular events that enable microbial pathogens to evade host defense mechanisms. In particular, we are interested in how bacteria that replicate inside mammalian cells create specialized vacuoles that support pathogen replication. We have been using Legionella pneumophila and Coxiella burnetii as model pathogens to study this process. We have been characterizing a type IV secretion system called Dot/Icm that delivers bacterial effector proteins into the eukaryotic host cell cytosol. The goals of this research are to determine the mechanism by which these bacterial effector proteins regulate phagosome maturation, modulate host immunity, and subvert eukaryotic cell functions.

Specialized Terms: Molecular; Cellular; Microbial pathogens; Bacteria; Vesicular transport; Legionella pneumophila; Coxiella burnetii; Macrophages; Protozoan; Proteins

Coauthors

Research Interests

Bacteria; Immune System; Macrophages; Protozoan Proteins; Legionella pneumophila; Coxiella burnetii; Vesicular Transport Proteins

Selected Publications