Costin Ionescu, MD, PhD
Assistant Professor of Clinical Medicine; Clinician
Research & Publications
Biography
Research Summary
I am interested the role of platelet activity in different forms of atherosclerosis.
Extensive Research Description
Platelets play a central role in atherosclerosis and treatment relies in anti-platelet therapies. However, there are different clinical phenotypes of atherosclerosis. Combining basic and clinical research approach to various clinical phenotypes, we are investigating the roles of platelets in coronary and peripheral vascular disease.
Coauthors
Selected Publications
- Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease.Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2021, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.
- Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients.Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.
- Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective.Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.
- Comorbidities frequency in Takotsubo syndrome: an international collaborative systematic review including 1109 patients.Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, Cacciotti L, Capucci A, Citro R, Delmas C, Guerra F, Ionescu CN, Lairez O, Larrauri-Reyes M, Lee PH, Mansencal N, Marazzi G, Mihos CG, Morel O, Nef HM, Nunez Gil IJ, Passaseo I, Pineda AM, Rosano G, Santana O, Schneck F, Song BG, Song JK, Teh AW, Ungprasert P, Valbusa A, Wahl A, Yoshida T, Gaudio C, Kaski JC. Comorbidities frequency in Takotsubo syndrome: an international collaborative systematic review including 1109 patients. The American Journal Of Medicine 2015, 128: 654.e11-9. PMID: 25660245, DOI: 10.1016/j.amjmed.2015.01.016.
- Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study).Ionescu CN, Chrissoheris MP, Slim HB, Slade M, Oen-Hsiao J, Donohue TJ, Bekui A, Ghantous AE. Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study). Connecticut Medicine 2014, 78: 133-8. PMID: 24772828.
- Left ventricular noncompaction and aneurysm revealed by left ventriculography.Ionescu CN, Turcot D. Left ventricular noncompaction and aneurysm revealed by left ventriculography. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2012, 80: 109-11. PMID: 21954168, DOI: 10.1002/ccd.23322.
- Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction.Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction. The Journal Of Invasive Cardiology 2010, 22: 474-8. PMID: 20944186.
- Long-term outcome of Tako-tsubo cardiomyopathy.Ionescu CN, Aguilar-Lopez CA, Sakr AE, Ghantous AE, Donohue TJ. Long-term outcome of Tako-tsubo cardiomyopathy. Heart, Lung & Circulation 2010, 19: 601-5. PMID: 20655278, DOI: 10.1016/j.hlc.2010.06.667.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Cardiovascular System | Firehawk Rapamycin Target Eluting Coronary Stent North American Trial (TARGET-IV_NA) |
| Diseases of the Cardiovascular System | Global, Post-Market, Prospective, Multi-Center, Randomized Controlled Trial of the VenaSeal Closure System vs. Surgical Stripping or Endothermal Ablation (ETA) for the Treatment of Early and Advanced Stage Superficial Venous Disease |
| Diseases of the Cardiovascular System | SHOWME-PAD (Peripheral Artery Disease) |