Costin Ionescu, MD, PhD
Assistant Professor of Medicine (Cardiovascular Medicine); Clinician
Research & Publications
Biography
News
Research Summary
I am interested the role of platelet activity in different forms of atherosclerosis.
Extensive Research Description
Platelets play a central role in atherosclerosis and treatment relies in anti-platelet therapies. However, there are different clinical phenotypes of atherosclerosis. Combining basic and clinical research approach to various clinical phenotypes, we are investigating the roles of platelets in coronary and peripheral vascular disease.
Coauthors
Selected Publications
- Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adultsLee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.
- TCT CONNECT-369 Real-World Safety and Efficacy Outcomes of the Pioneer Plus Catheter in Endovascular Revascularization of Lower Extremity Chronic Total OcclusionsSheikh A, Llanos-Chea F, Jelani Q, Narayanan M, Attaran R, Schneider M, Ionescu C, Regan C, Nagpal S, Smolderen K, Mena-Hurtado C. TCT CONNECT-369 Real-World Safety and Efficacy Outcomes of the Pioneer Plus Catheter in Endovascular Revascularization of Lower Extremity Chronic Total Occlusions. Journal Of The American College Of Cardiology 2020, 76: b159. DOI: 10.1016/j.jacc.2020.09.391.
- Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal diseaseAnantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.
- TCT-552 Drug-Coated Balloon Versus Plain Old Balloon Angioplasty in Femoropopliteal Disease: A Meta-Analysis of Randomized Controlled TrialsNarayanan M, Shah S, Garcia S, Ionescu C, Regan C, Mena-Hurtado C. TCT-552 Drug-Coated Balloon Versus Plain Old Balloon Angioplasty in Femoropopliteal Disease: A Meta-Analysis of Randomized Controlled Trials. Journal Of The American College Of Cardiology 2019, 74: b545. DOI: 10.1016/j.jacc.2019.08.657.
- Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patientsJain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.
- Antiplatelet therapy for tibial balloon angioplasty: A clinical perspectiveIonescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.
- Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 PatientsPelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, Cacciotti L, Capucci A, Citro R, Delmas C, Guerra F, Ionescu CN, Lairez O, Larrauri-Reyes M, Lee PH, Mansencal N, Marazzi G, Mihos CG, Morel O, Nef HM, Gil I, Passaseo I, Pineda AM, Rosano G, Santana O, Schneck F, Song BG, Song JK, Teh AW, Ungprasert P, Valbusa A, Wahl A, Yoshida T, Gaudio C, Kaski JC. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients. The American Journal Of Medicine 2015, 128: 654.e11-654.e19. PMID: 25660245, DOI: 10.1016/j.amjmed.2015.01.016.
- Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study).Ionescu CN, Chrissoheris MP, Slim HB, Slade M, Oen-Hsiao J, Donohue TJ, Bekui A, Ghantous AE. Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study). Connecticut Medicine 2014, 78: 133-8. PMID: 24772828.
- Left ventricular noncompaction and aneurysm revealed by left ventriculographyIonescu CN, Turcot D. Left ventricular noncompaction and aneurysm revealed by left ventriculography. Catheterization And Cardiovascular Interventions 2011, 80: 109-111. PMID: 21954168, DOI: 10.1002/ccd.23322.
- Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction.Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction. Journal Of Invasive Cardiology 2010, 22: 474-8. PMID: 20944186.
- Unexpected massive myocardial calcificationIonescu C, Marcu C. Unexpected massive myocardial calcification. Netherlands Heart Journal 2010, 1-5. DOI: 10.1007/s12471-010-0009-9.
- Long-term Outcome of Tako-tsubo CardiomyopathyIonescu CN, Aguilar-Lopez CA, Sakr AE, Ghantous AE, Donohue TJ. Long-term Outcome of Tako-tsubo Cardiomyopathy. Heart Lung And Circulation 2010, 19: 601-605. PMID: 20655278, DOI: 10.1016/j.hlc.2010.06.667.