Clare Flannery, MD

• Christian Pettker
• Emre Seli
• Farrah Saleh
• Gary Cline
• Gerald I Shulman
• Harvey Kliman
• Hugh Taylor
• Kitt Petersen
• Lauren Perley
• Maria Lalioti
• Pinar Kodaman
• Richard Kibbey
• Sachin Majumdar
• Varman Samuel
• Vikki M Abrahams
• Yingqun Huang

Adenocarcinoma; Diabetes Mellitus; Endometrial Hyperplasia; Obesity

• Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma.Flannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS. Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. The Journal Of Clinical Endocrinology And Metabolism 2016, 101: 2883-91. PMID: 27088794, PMCID: PMC4929835, DOI: 10.1210/jc.2016-1795.
• Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium.Flannery CA, Fleming AG, Choe GH, Naqvi H, Zhang M, Sharma A, Taylor HS. Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology 2016, 157: 3699-3708. PMID: 27267714, PMCID: PMC5045514, DOI: 10.1210/en.2016-1233.
• Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms.Flannery CA, Rowzee AM, Choe GH, Saleh FL, Radford CC, Taylor HS, Wood TL. Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms. Endocrinology 2016, 157: 1702-8. PMID: 26862994, PMCID: PMC4816738, DOI: 10.1210/en.2015-1698.
• Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly.Flannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes 2012, 61: 2711-7. PMID: 22829450, PMCID: PMC3478531, DOI: 10.2337/db12-0206.
• Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI.Flannery CA, Rackow B, Cong X, Duran E, Selen DJ, Burgert TS. Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatric Diabetes 2013, 14: 42-9. PMID: 22925367, PMCID: PMC4864958, DOI: 10.1111/j.1399-5448.2012.00902.x.
• Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals.Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13705-9. PMID: 21808028, PMCID: PMC3158147, DOI: 10.1073/pnas.1110105108.
• Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metabolism 2009, 10: 499-506. PMID: 19945407, PMCID: PMC2799933, DOI: 10.1016/j.cmet.2009.10.007.
• Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance.Weismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Shulman GI, Samuel VT. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance. Diabetologia 2011, 54: 935-44. PMID: 21190014, PMCID: PMC4061906, DOI: 10.1007/s00125-010-1984-5.
• The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, Shulman GI, Huang Y. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Research 2014, 42: 13799-811. PMID: 25399420, PMCID: PMC4267628, DOI: 10.1093/nar/gku1160.
• mRNA-binding protein TIA-1 reduces cytokine expression in human endometrial stromal cells and is down-regulated in ectopic endometrium.Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-binding protein TIA-1 reduces cytokine expression in human endometrial stromal cells and is down-regulated in ectopic endometrium. The Journal Of Clinical Endocrinology And Metabolism 2014, 99: E2610-9. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.
• Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency.Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM. Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2015, 73: 362-71. PMID: 25394884, PMCID: PMC4356646, DOI: 10.1111/aji.12339.
• H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis.Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Molecular Medicine 2015, 7: 996-1003. PMID: 26089099, PMCID: PMC4551339, DOI: 10.15252/emmm.201505245.
• Time course analysis of RNA quality in placenta preserved by RNAlater or flash freezing.Martin NM, Cooke KM, Radford CC, Perley LE, Silasi M, Flannery CA. Time course analysis of RNA quality in placenta preserved by RNAlater or flash freezing. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2017, 77 PMID: 28138995, PMCID: PMC5397349, DOI: 10.1111/aji.12637.
• Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOS.Rackow BW, Vanden Brink H, Hammers L, Flannery CA, Lujan ME, Burgert TS. Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOS. The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine 2018, 62: 288-293. PMID: 29217212, DOI: 10.1016/j.jadohealth.2017.09.005.
• Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2.Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology And Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.
• Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management.Araque KA, Kadayakkara DK, Gigauri N, Sheehan D, Majumdar S, Buller G, Flannery CA. Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management. BMJ Open Quality 2018, 7: e000120. PMID: 29756070, PMCID: PMC5942454, DOI: 10.1136/bmjoq-2017-000120.