Chris Cotsapas, PhD
Associate Professor of Neurology; Associate Professor of Genetics
Research & Publications
Biography
News
Research Summary
We look for genetic factors that predispose to disease and try to understand the biology they perturb. We ask what genes are perturbed, what processes they participate in and whether these perturbations are sufficient to induce differences at the molecular and cellular levels.This gives us novel targets for biomarkers, diagnosis and treatment.
Our approach encompasses statistical and computational tools, genetics and molecular biology. We are a hybrid lab with strong quantitative and experimental skills and we cycle between hypotheses generated by rigorous analysis and confirmation and discovery in experimental systems.
Our approach encompasses statistical and computational tools, genetics and molecular biology. We are a hybrid lab with strong quantitative and experimental skills and we cycle between hypotheses generated by rigorous analysis and confirmation and discovery in experimental systems.
Coauthors
Research Interests
Arthritis, Rheumatoid; Autoimmune Diseases; Diabetes Mellitus, Type 1; Genetics; Genetics, Medical; Genetics, Population; Graves Disease; Immune System Diseases; Lupus Erythematosus, Systemic; Multiple Sclerosis; Thyroiditis, Autoimmune; Inflammatory Bowel Diseases; Human Genome Project; Computational Biology; Autoimmune Diseases of the Nervous System; Demyelinating Autoimmune Diseases, CNS; Genomics; Genetic Research; Systems Biology
Selected Publications
- Immune-mediated disease genetics: the shared basis of pathogenesis.Cotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis. Trends In Immunology 2013, 34:22-6.
- Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013, 81:956-63.