We are trying to understand how diseases of the brain and immune system arise, what drives them, and what processes we might target to develop new therapies. We are also trying to understand why men and women develop these diseases at different rates and experience different symptoms and severity: over 80% of multiple sclerosis patients are women, for example, but we do not understand why.
Our approach encompasses statistical and computational tools, genetics and molecular biology. We are a hybrid lab with strong quantitative and experimental skills and we cycle between hypotheses generated by rigorous analysis and confirmation and discovery in experimental systems.
Arthritis, Rheumatoid; Autoimmune Diseases; Diabetes Mellitus, Type 1; Epilepsy; Genetics; Genetics, Medical; Genetics, Population; Graves Disease; Immune System Diseases; Lupus Erythematosus, Systemic; Multiple Sclerosis; Thyroiditis, Autoimmune; Inflammatory Bowel Diseases; Human Genome Project; Computational Biology; Autoimmune Diseases of the Nervous System; Demyelinating Autoimmune Diseases, CNS; Genomics; Genetic Research; Systems Biology