Chris Cotsapas, PhD

• David A. Hafler

Arthritis, Rheumatoid; Autoimmune Diseases; Diabetes Mellitus, Type 1; Epilepsy; Genetics; Genetics, Medical; Genetics, Population; Graves Disease; Immune System Diseases; Lupus Erythematosus, Systemic; Multiple Sclerosis; Thyroiditis, Autoimmune; Inflammatory Bowel Diseases; Human Genome Project; Computational Biology; Autoimmune Diseases of the Nervous System; Demyelinating Autoimmune Diseases, CNS; Genomics; Genetic Research; Systems Biology

• Genetics of multiple sclerosis: lessons from polygenicityGoris A, Vandebergh M, McCauley JL, Saarela J, Cotsapas C. Genetics of multiple sclerosis: lessons from polygenicity The Lancet Neurology 2022, 21: 830-842. PMID: 35963264, DOI: 10.1016/s1474-4422(22)00255-1.
• Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19?Cotsapas C, Saarela J, Farmer JR, Scaria V, Abraham RS. Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19? Journal Of Clinical Investigation 2021, 131 PMID: 34061775, PMCID: PMC8279660, DOI: 10.1172/jci149459.
• Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic DisordersBlokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R, St Clair D, Lencz T, Mowry B, Periyasamy S, Cairns M, Tooney P, Wu J, Kelly B, Kirov G, Sullivan P, Corvin A, Riley B, Esko T, Milani L, Jönsson E, Palotie A, Ehrenreich H, Begemann M, Steixner-Kumar A, Sham P, Iwata N, Weinberger D, Gejman P, Sanders A, Buxbaum J, Rujescu D, Giegling I, Konte B, Hartmann A, Bramon E, Murray R, Pato M, Lee J, Melle I, Molden E, Ophoff R, McQuillin A, Bass N, Adolfsson R, Malhotra A, Martin N, Fullerton J, Mitchell P, Schofield P, Forstner A, Degenhardt F, Schaupp S, Comes A, Kogevinas M, Guzman-Parra J, Reif A, Streit F, Sirignano L, Cichon S, Grigoroiu-Serbanescu M, Hauser J, Lissowska J, Mayoral F, Müller-Myhsok B, Świątkowska B, Schulze T, Nöthen M, Rietschel M, Kelsoe J, Leboyer M, Jamain S, Etain B, Bellivier F, Vincent J, Alda M, O’Donovan C, Cervantes P, Biernacka J, Frye M, McElroy S, Scott L, Stahl E, Landén M, Hamshere M, Smeland O, Djurovic S, Vaaler A, Andreassen O, Baune B, Air T, Preisig M, Uher R, Levinson D, Weissman M, Potash J, Shi J, Knowles J, Perlis R, Lucae S, Boomsma D, Penninx B, Hottenga J, de Geus E, Willemsen G, Milaneschi Y, Tiemeier H, Grabe H, Teumer A, Van der Auwera S, Völker U, Hamilton S, Magnusson P, Viktorin A, Mehta D, Mullins N, Adams M, Breen G, McIntosh A, Lewis C, Hougaard D, Nordentoft M, Mors O, Mortensen P, Werge T, Als T, Børglum A, Petryshen T, Smoller J, Goldstein J, Ripke S, Neale B, Corvin A, Walters J, Farh K, Holmans P, Lee P, Bulik-Sullivan B, Collier D, Huang H, Pers T, Agartz I, Agerbo E, Albus M, Alexander M, Amin F, Bacanu S, Begemann M, Belliveau R, Bene J, Bergen S, Bevilacqua E, Bigdeli T, Black D, Bruggeman R, Buccola N, Buckner R, Byerley W, Cahn W, Cai G, Campion D, Cantor R, Carr V, Carrera N, Catts S, Chambert K, Chan R, Chen R, Chen E, Cheng W, Cheung E, Chong S, Cloninger C, Cohen D, Cohen N, Cormican P, Craddock N, Crowley J, Curtis D, Davidson M, Davis K, Degenhardt F, Del Favero J, Demontis D, Dikeos D, Dinan T, Djurovic S, Donohoe G, Drapeau E, Duan J, Dudbridge F, Durmishi N, Eichhammer P, Eriksson J, Escott-Price V, Essioux L, Fanous A, Farrell M, Frank J, Franke L, Freedman R, Freimer N, Friedl M, Friedman J, Fromer M, Genovese G, Georgieva L, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein J, Golimbet V, Gopal S, Gratten J, de Haan L, Hammer C, Hamshere M, Hansen M, Hansen T, Haroutunian V, Hartmann A, Henskens F, Herms S, Hirschhorn J, Hoffmann P, Hofman A, Hollegaard M, Hougaard D, Ikeda M, Joa I, Julià A, Kahn R, Kalaydjieva L, Karachanak-Yankova S, Karjalainen J, Kavanagh D, Keller M, Kennedy J, Khrunin A, Kim Y, Klovins J, Knowles J, Konte B, Kucinskas V, Kucinskiene Z, Kuzelova-Ptackova H, Kähler A, Laurent C, Lee Chee Keong J, Lee S, Legge S, Lerer B, Li M, Li T, Liang K, Lieberman J, Limborska S, Loughland C, Lubinski J, Lönnqvist J, Macek M, Magnusson P, Maher B, Maier W, Mallet J, Marsal S, Mattheisen M, Mattingsdal M, McCarley R, McDonald C, McIntosh A, Meier S, Meijer C, Melegh B, Melle I, Mesholam-Gately R, Metspalu A, Michie P, Milani L, Milanova V, Mokrab Y, Morris D, Mors O, Murphy K, Murray R, Myin-Germeys I, Müller-Myhsok B, Nelis M, Nenadic I, Nertney D, Nestadt G, Nicodemus K, Nikitina-Zake L, Nisenbaum L, Nordin A, O’Callaghan E, O’Dushlaine C, O’Neill F, Oh S, Olincy A, Olsen L, Van Os J, Pantelis C, Papadimitriou G, Papiol S, Parkhomenko E, Pato M, Paunio T, Pejovic-Milovancevic M, Perkins D, Pietiläinen O, Pimm J, Pocklington A, Powell J, Price A, Pulver A, Purcell S, Quested D, Rasmussen H, Reichenberg A, Reimers M, Richards A, Roffman J, Roussos P, Ruderfer D, Salomaa V, Sanders A, Schall U, Schubert C, Schulze T, Schwab S, Scolnick E, Scott R, Seidman L, Shi J, Sigurdsson E, Silagadze T, Silverman J, Sim K, Slominsky P, Smoller J, So H, Spencer C, Stahl E, Stefansson H, Steinberg S, Stogmann E, Straub R, Strengman E, Strohmaier J, Stroup T, Subramaniam M, Suvisaari J, Svrakic D, Szatkiewicz J, Söderman E, Thirumalai S, Toncheva D, Tosato S, Veijola J, Waddington J, Walsh D, Wang D, Wang Q, Webb B, Weiser M, Wildenauer D, Williams N, Williams S, Witt S, Wolen A, Wong E, Wormley B, Xi H, Zai C, Zheng X, Zimprich F, Wray N, Stefansson K, Visscher P, Adolfsson R, Andreassen O, Blackwood D, Bramon E, Buxbaum J, Børglum A, Cichon S, Darvasi A, Domenici E, Ehrenreich H, Esko T, Gejman P, Gill M, Gurling H, Hultman C, Iwata N, Jablensky A, Jönsson E, Kendler K, Kirov G, Knight J, Lencz T, Levinson D, Li Q, Liu J, Malhotra A, McCarroll S, McQuillin A, Moran J, Mortensen P, Periyasamy S, Cairns M, Tooney P, Wu J, Kelly B, Mowry B, Nöthen M, Ophoff R, Owen M, Palotie A, Pato C, Petryshen T, Posthuma D, Rietschel M, Riley B, Rujescu D, Sham P, Sklar P, St Clair D, Weinberger D, Wendland J, Werge T, Daly M, Sullivan P, O’Donovan M, Donnelly P, Barroso I, Blackwell J, Bramon E, Brown M, Casas J, Corvin A, Deloukas P, Duncanson A, Jankowski J, Markus H, Mathew C, Palmer C, Plomin R, Rautanen A, Sawcer S, Trembath R, Viswanathan A, Wood N, Spencer C, Band G, Bellenguez C, Donnelly P, Freeman C, Giannoulatou E, Hellenthal G, Pearson R, Pirinen M, Strange A, Su Z, Vukcevic D, Langford C, Barroso I, Blackburn H, Bumpstead S, Deloukas P, Dronov S, Edkins S, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt S, Jayakumar A, Liddle J, McCann O, Potter S, Ravindrarajah R, Ricketts M, Tashakkori-Ghanbaria A, Waller M, Weston P, Whittaker P, Widaa S, Mathew C, Blackwell J, Brown M, Corvin A, McCarthy M, Spencer C, Arranz M, Bakker S, Bender S, Bramon E, Collier D, Crespo-Facorro B, Hall J, Iyegbe C, Jablensky A, Kahn R, Kalaydjieva L, Lawrie S, Lewis C, Lin K, Linszen D, Mata I, McIntosh A, Murray R, Ophoff R, Van Os J, Powell J, Rujescu D, Walshe M, Weisbrod M, Wiersma D, Stahl E, Breen G, Forstner A, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman J, Gaspar H, de Leeuw C, Steinberg S, Whitehead Pavlides J, Trzaskowski M, Byrne E, Pers T, Holmans P, Richards A, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als T, Anjorin A, Antilla V, Awasthi S, Badner J, Bækvad-Hansen M, Barchas J, Bass N, Bauer M, Belliveau R, Bergen S, Pedersen C, Bøen E, Boks M, Boocock J, Budde M, Bunney W, Burmeister M, Bybjerg-Grauholm J, Byerley W, Casas M, Cerrato F, Cervantes P, Chambert K, Charney A, Chen D, Churchhouse C, Clarke T, Coryell W, Craig D, Cruceanu C, Curtis D, Czerski P, Dale A, de Jong S, Degenhardt F, Del-Favero J, DePaulo J, Djurovic S, Dobbyn A, Dumont A, Elvsåshagen T, Escott-Price V, Fan C, Fischer S, Flickinger M, Foroud T, Forty L, Frank J, Fraser C, Freimer N, Gade K, Gage D, Garnham J, Giambartolomei C, Pedersen M, Goldstein J, Gordon S, Gordon-Smith K, Green E, Green M, Greenwood T, Grove J, Guan W, Guzman-Parra J, Hamshere M, Hautzinger M, Heilbronner U, Herms S, Hipolito M, Hoffmann P, Holland D, Huckins L, Jamain S, Johnson J, Kandaswamy R, Karlsson R, Kennedy J, Kittel-Schneider S, Knowles J, Kogevinas M, Koller A, Kupka R, Lavebratt C, Lawrence J, Lawson W, Leber M, Lee P, Levy S, Li J, Liu C, Lucae S, Maaser A, MacIntyre D, Mahon P, Maier W, Martinsson L, McCarroll S, McGuffin P, McInnis M, McKay J, Medeiros H, Medland S, Meng F, Milani L, Montgomery G, Morris D, Mühleisen T, Mullins N, Nguyen H, Nievergelt C, Adolfsson A, Nwulia E, O'Donovan C, Olde Loohuis L, Ori A, Oruc L, Ösby U, Perlis R, Perry A, Pfennig A, Potash J, Purcell S, Regeer E, Reif A, Reinbold C, Rice J, Rivas F, Rivera M, Roussos P, Ruderfer D, Ryu E, Sánchez-Mora C, Schatzberg A, Scheftner W, Schork N, Weickert C, Shehktman T, Shilling P, Sigurdsson E, Slaney C, Smeland O, Sobell J, Hansen C, Spijker A, St Clair D, Steffens M, Strauss J, Streit F, Strohmaier J, Szelinger S, Thompson R, Thorgeirsson T, Treutlein J, Vedder H, Wang W, Watson S, Weickert T, Witt S, Xi S, Xu W, Young A, Zandi P, Zhang P, Zöllner S, Wray N, Ripke S, Mattheisen M, Trzaskowski M, Byrne E, Abdellaoui A, Adams M, Agerbo E, Air T, Andlauer T, Bacanu S, Bækvad-Hansen M, Beekman A, Bigdeli T, Binder E, Bryois J, Buttenschøn H, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen J, Clarke T, Coleman J, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford G, Davies G, Deary I, Degenhardt F, Derks E, Direk N, Dolan C, Dunn E, Eley T, Escott-Price V, Hassan Kiadeh F, Finucane H, Foo J, Forstner A, Frank J, Gaspar H, Gill M, Goes F, Gordon S, Grove J, Hall L, Hansen C, Hansen T, Herms S, Hickie I, Hoffmann P, Homuth G, Horn C, Hottenga J, Hougaard D, Howard D, Ising M, Jansen R, Jones I, Jones L, Jorgenson E, Knowles J, Kohane I, Kraft J, Kretzschmar W, Kutalik Z, Li Y, Lind P, MacIntyre D, MacKinnon D, Maier R, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland S, Mehta D, Middeldorp C, Mihailov E, Milaneschi Y, Milani L, Mondimore F, Montgomery G, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard M, Nyholt D, O'Reilly P, Oskarsson H, Owen M, Painter J, Pedersen C, Pedersen M, Peterson R, Peyrot W, Pistis G, Posthuma D, Quiroz J, Qvist P, Rice J, Riley B, Rivera M, Mirza S, Schoevers R, Schulte E, Shen L, Shi J, Shyn S, Sigurdsson E, Sinnamon G, Smit J, Smith D, Stefansson H, Steinberg S, Streit F, Strohmaier J, Tansey K, Teismann H, Teumer A, Thompson W, Thomson P, Thorgeirsson T, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden A, Umbricht D, Van der Auwera S, van Hemert A, Viktorin A, Visscher P, Wang Y, Webb B, Weinsheimer S, Wellmann J, Willemsen G, Witt S, Wu Y, Xi H, Yang J, Zhang F, Arolt V, Baune B, Berger K, Boomsma D, Cichon S, Dannlowski U, de Geus E, DePaulo J, Domenici E, Domschke K, Esko T, Grabe H, Hamilton S, Hayward C, Heath A, Kendler K, Kloiber S, Lewis G, Li Q, Lucae S, Madden P, Magnusson P, Martin N, McIntosh A, Metspalu A, Mors O, Mortensen P, Müller-Myhsok B, Nordentoft M, Nöthen M, O'Donovan M, Paciga S, Pedersen N, Penninx B, Perlis R, Porteous D, Potash J, Preisig M, Rietschel M, Schaefer C, Schulze T, Smoller J, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman M, Werge T, Lewis C, Levinson D, Breen G, Børglum A, Sullivan P, Alda M, Blokland G, Børglum A, Bortolato M, Bralten J, Breen G, Bulik C, Burton C, Byrne E, Carey C, Coleman J, Davis L, Demontis D, Duncan L, Edenberg H, Erdman L, Faraone S, Goldstein J, Goleva S, Grove J, Guo W, Hübel C, Huckins L, Khramtsova E, Lee P, Martin J, Mathews C, Mattheisen M, Neale B, Peterson R, Petryshen T, Robinson E, Smoller J, Stahl E, Stranger B, Traglia M, Walters R, Weiss L, Werge T, Winham S, Wray N, Yao Y, Børglum A, Hougaard D, Nordentoft M, Mors O, Mortensen P, Werge T, Skajaa K, Nöthen M, Owen M, Yolken R, Plath N, Mill J, Geschwind D. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders Biological Psychiatry 2021, 91: 102-117. PMID: 34099189, PMCID: PMC8458480, DOI: 10.1016/j.biopsych.2021.02.972.
• MHC associations with clinical and autoantibody manifestations in European SLEMorris DL, Fernando MM, Taylor KE, Chung SA, Nititham J, Alarcón-Riquelme ME, Barcellos LF, Behrens TW, Cotsapas C, Gaffney PM, Graham RR, Pons-Estel BA, Gregersen PK, Harley JB, Hauser SL, Hom G, Langefeld CD, Noble JA, Rioux JD, Seldin MF, Vyse T, Criswell L. MHC associations with clinical and autoantibody manifestations in European SLE Genes & Immunity 2014, 15: 210-217. PMID: 24598797, PMCID: PMC4102853, DOI: 10.1038/gene.2014.6.
• Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosisQuerol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis Neurology 2013, 81: 956-963. PMID: 23921886, PMCID: PMC3888197, DOI: 10.1212/wnl.0b013e3182a43b48.
• Immune-mediated disease genetics: the shared basis of pathogenesisCotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis Trends In Immunology 2012, 34: 22-26. PMID: 23031829, DOI: 10.1016/j.it.2012.09.001.
• Expression analysis of loci associated with type 2 diabetes in human tissuesCotsapas C, Prokunina-Olsson L, Welch C, Saxena R, Weaver C, Usher N, Guiducci C, Bonakdar S, Turner N, LaCroix B, Hall JL. Expression analysis of loci associated with type 2 diabetes in human tissues Diabetologia 2010, 53: 2334-2339. PMID: 20703447, DOI: 10.1007/s00125-010-1861-2.
• Genetic variation and the control of transcription.Cotsapas C, Chan E, Kirk M, Tanaka M, Little P. Genetic variation and the control of transcription. Cold Spring Harbor Symposia On Quantitative Biology 2003, 68: 109-14. PMID: 15338608, DOI: 10.1101/sqb.2003.68.109.