Chiang-Shan Ray Li, MD, PhD
Professor of Psychiatry and of Neuroscience
Research & Publications
Biography
News
Research Summary
Our research focuses on combining psychophysics, neural imaging, and computation to understand how brain works at the systems level. In particular, we are interested in the neural processes of cognitive control and how deficits in these processes may contribute to the pathogenesis of substance use disorders and other psychiatric and neurological conditions. Our research also examines the neurochemical basis of cognition. We employ pharmacological manipulation and resting state as well task-based brain imaging to examine the catecholaminergic and cholinergic circuits of importance to neuropsychiatric illnesses. We collaborate widely with investigators in basic and clinical neuroscience on and off campus.
Specialized Terms: Systems neuroscience; Psychophysics; Neural imaging; Cognitive control; Addiction; Psychostimulant; Alcohol; Anxiety disorders
Coauthors
Research Interests
Alcohols; Anatomy; Behavior and Behavior Mechanisms; Mental Disorders; Biological Therapy; Central Nervous System; Nervous System; Nervous System Diseases; Psychological Phenomena; Therapeutics; Behavior Control; Research Subjects; Drug Users; Chemicals and Drugs; Psychiatry and Psychology
Selected Publications
- Resting state functional connectivity of the basal nucleus of Meynert in humans: in comparison to the ventral striatum and the effects of age.Li CS, Ide JS, Zhang S, Hu S, Chao HH, Zaborszky L. Resting state functional connectivity of the basal nucleus of Meynert in humans: in comparison to the ventral striatum and the effects of age. NeuroImage 2014, 97:321-32.
- The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults.Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults. Experimental And Clinical Psychopharmacology 2014, 22:154-65.
- Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence.Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain : A Journal Of Neurology 2013, 136:1231-44.
- Neural bases of individual variation in decision time.Hu S, Tseng YC, Winkler AD, Li CS. Neural bases of individual variation in decision time. Human Brain Mapping 2014, 35:2531-42.
- Bayesian prediction and evaluation in the anterior cingulate cortex.Ide JS, Shenoy P, Yu AJ, Li CS. Bayesian prediction and evaluation in the anterior cingulate cortex. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2013, 33:2039-47.
- Resting-state functional connectivity of the medial superior frontal cortex.Zhang S, Ide JS, Li CS. Resting-state functional connectivity of the medial superior frontal cortex. Cerebral Cortex (New York, N.Y. : 1991) 2012, 22:99-111.
- A cerebellar thalamic cortical circuit for error-related cognitive control.Ide JS, Li CS. A cerebellar thalamic cortical circuit for error-related cognitive control. NeuroImage 2011, 54:455-64.
- Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients.Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107:14455-9.
- Functional connectivity delineates distinct roles of the inferior frontal cortex and presupplementary motor area in stop signal inhibition.Duann JR, Ide JS, Luo X, Li CS. Functional connectivity delineates distinct roles of the inferior frontal cortex and presupplementary motor area in stop signal inhibition. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2009, 29:10171-9.
- Neural correlates of speeded as compared with delayed responses in a stop signal task: an indirect analog of risk taking and association with an anxiety trait.Li CS, Chao HH, Lee TW. Neural correlates of speeded as compared with delayed responses in a stop signal task: an indirect analog of risk taking and association with an anxiety trait. Cerebral Cortex (New York, N.Y. : 1991) 2009, 19:839-48.
- Altered impulse control in alcohol dependence: neural measures of stop signal performance.Li CS, Luo X, Yan P, Bergquist K, Sinha R. Altered impulse control in alcohol dependence: neural measures of stop signal performance. Alcoholism, Clinical And Experimental Research 2009, 33:740-50.
- Neural correlates of impulse control during stop signal inhibition in cocaine-dependent men.Li CS, Huang C, Yan P, Bhagwagar Z, Milivojevic V, Sinha R. Neural correlates of impulse control during stop signal inhibition in cocaine-dependent men. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2008, 33:1798-806.
- Imaging response inhibition in a stop-signal task: neural correlates independent of signal monitoring and post-response processing.Li CS, Huang C, Constable RT, Sinha R. Imaging response inhibition in a stop-signal task: neural correlates independent of signal monitoring and post-response processing. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2006, 26:186-92.
- A psychophysical measure of attention deficit in children with attention-deficit/hyperactivity disorder.Li CS, Lin WH, Chang HL, Hung YW. A psychophysical measure of attention deficit in children with attention-deficit/hyperactivity disorder. Journal Of Abnormal Psychology 2004, 113:228-36.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Nervous System | Imaging dopamine mediated effects of stress on inhibitory control |
| Alcohol Addiction | Sleep Intervention for Heavy Drinking Young Adults |
| Diseases of the Nervous System; Mental Health & Behavioral Research | Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder |