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Chi Liu, PhD

Associate Professor of Radiology and Biomedical Imaging

Contact Information

Chi Liu, PhD

Extensive Research Description

Radiation dose reduction methods in PET/SPECT/CT

Machine learning and deep learning in imaging applications

Motion correction methods for PET/CT and SPECT/CT

Early detection of chemotherapy-induced cardiotoxicity through advanced cardiac imaging



Coauthors

Selected Publications

  • Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT.Chen X, Zhou B, Xie H, Shi L, Liu H, Holler W, Lin M, Liu YH, Miller EJ, Sinusas AJ, Liu C. Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT. European Journal Of Nuclear Medicine And Molecular Imaging 2022 PMID: 35169887, DOI: 10.1007/s00259-022-05718-8.
  • Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT.Chen X, Hendrik Pretorius P, Zhou B, Liu H, Johnson K, Liu YH, King MA, Liu C. Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2022 PMID: 35474443, DOI: 10.1007/s12350-022-02978-7.
  • DuDoDR-Net: Dual-domain data consistent recurrent network for simultaneous sparse view and metal artifact reduction in computed tomography.Zhou B, Chen X, Zhou SK, Duncan JS, Liu C. DuDoDR-Net: Dual-domain data consistent recurrent network for simultaneous sparse view and metal artifact reduction in computed tomography. Medical Image Analysis 2022, 75: 102289. PMID: 34758443, PMCID: PMC8678361, DOI: 10.1016/j.media.2021.102289.
  • PET respiratory motion correction: quo vadis?Lamare F, Bousse A, Thielemans K, Liu C, Merlin T, Fayad H, Visvikis D. PET respiratory motion correction: quo vadis? Physics In Medicine And Biology 2021 PMID: 34915465, DOI: 10.1088/1361-6560/ac43fc.
  • Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation.Liu H, Wu J, Shi L, Liu Y, Miller E, Sinusas A, Liu YH, Liu C. Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021 PMID: 34671940, DOI: 10.1007/s12350-021-02817-1.
  • Artificial Intelligence-Based Image Enhancement in PET Imaging: Noise Reduction and Resolution Enhancement.Liu J, Malekzadeh M, Mirian N, Song TA, Liu C, Dutta J. Artificial Intelligence-Based Image Enhancement in PET Imaging: Noise Reduction and Resolution Enhancement. PET Clinics 2021, 16: 553-576. PMID: 34537130, PMCID: PMC8457531, DOI: 10.1016/j.cpet.2021.06.005.
  • Nuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development.Bradshaw TJ, Boellaard R, Dutta J, Jha AK, Jacobs P, Li Q, Liu C, Sitek A, Saboury B, Scott PJH, Slomka PJ, Sunderland JJ, Wahl RL, Yousefirizi F, Zuehlsdorff S, Rahmim A, Buvat I. Nuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2022, 63: 500-510. PMID: 34740952, DOI: 10.2967/jnumed.121.262567.
  • Automatic Inter-Frame Patient Motion Correction for Dynamic Cardiac PET Using Deep Learning.Shi L, Lu Y, Dvornek N, Weyman CA, Miller EJ, Sinusas AJ, Liu C. Automatic Inter-Frame Patient Motion Correction for Dynamic Cardiac PET Using Deep Learning. IEEE Transactions On Medical Imaging 2021, 40: 3293-3304. PMID: 34018932, PMCID: PMC8670362, DOI: 10.1109/TMI.2021.3082578.
  • Generation of parametric Ki images for FDG PET using two 5-min scans.Wu J, Liu H, Ye Q, Gallezot JD, Naganawa M, Miao T, Lu Y, Chen MK, Esserman DA, Kyriakides TC, Carson RE, Liu C. Generation of parametric Ki images for FDG PET using two 5-min scans. Medical Physics 2021, 48: 5219-5231. PMID: 34287939, DOI: 10.1002/mp.15113.
  • Limited View Tomographic Reconstruction Using a Cascaded Residual Dense Spatial-Channel Attention Network With Projection Data Fidelity Layer.Zhou B, Kevin Zhoua S, Duncan JS, Liu C. Limited View Tomographic Reconstruction Using a Cascaded Residual Dense Spatial-Channel Attention Network With Projection Data Fidelity Layer. IEEE Transactions On Medical Imaging 2021, 40: 1792-1804. PMID: 33729929, PMCID: PMC8325575, DOI: 10.1109/TMI.2021.3066318.
  • Generation of synthetic PET images of synaptic density and amyloid from 18 F-FDG images using deep learning.Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai YJ, Naganawa M, Ma T, Liu Y, Chen MK, Mecca AP, O'Dell RS, van Dyck CH, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18 F-FDG images using deep learning. Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
  • MDPET: A Unified Motion Correction and Denoising Adversarial Network for Low-Dose Gated PET.Zhou B, Tsai YJ, Chen X, Duncan JS, Liu C. MDPET: A Unified Motion Correction and Denoising Adversarial Network for Low-Dose Gated PET. IEEE Transactions On Medical Imaging 2021, 40: 3154-3164. PMID: 33909561, DOI: 10.1109/TMI.2021.3076191.
  • CT-free attenuation correction for dedicated cardiac SPECT using a 3D dual squeeze-and-excitation residual dense network.Chen X, Zhou B, Shi L, Liu H, Pang Y, Wang R, Miller EJ, Sinusas AJ, Liu C. CT-free attenuation correction for dedicated cardiac SPECT using a 3D dual squeeze-and-excitation residual dense network. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021 PMID: 34085168, DOI: 10.1007/s12350-021-02672-0.
  • Pitfalls on PET/CT Due to Artifacts and Instrumentation.Tsai YJ, Liu C. Pitfalls on PET/CT Due to Artifacts and Instrumentation. Seminars In Nuclear Medicine 2021, 51: 646-656. PMID: 34243906, PMCID: PMC8490278, DOI: 10.1053/j.semnuclmed.2021.06.015.
  • Multi-Tracer Positron Emission Tomography Quantification of Sympathetic Innervation: Tracer Similarity But Not Equivalence.Sinusas AJ, Liu C. Multi-Tracer Positron Emission Tomography Quantification of Sympathetic Innervation: Tracer Similarity But Not Equivalence. JACC. Cardiovascular Imaging 2021, 14: 1437-1439. PMID: 33221231, DOI: 10.1016/j.jcmg.2020.10.007.
  • Patient motion correction for dynamic cardiac PET: Current status and challenges.Lu Y, Liu C. Patient motion correction for dynamic cardiac PET: Current status and challenges. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27: 1999-2002. PMID: 30421380, DOI: 10.1007/s12350-018-01513-x.
  • Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT.Shi L, Lu Y, Wu J, Gallezot JD, Boutagy N, Thorn S, Sinusas AJ, Carson RE, Liu C. Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT. IEEE Transactions On Medical Imaging 2020, 39: 119-128. PMID: 31180845, PMCID: PMC7030971, DOI: 10.1109/TMI.2019.2921969.
  • Deep learning-based attenuation map generation for myocardial perfusion SPECT.Shi L, Onofrey JA, Liu H, Liu YH, Liu C. Deep learning-based attenuation map generation for myocardial perfusion SPECT. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 47: 2383-2395. PMID: 32219492, DOI: 10.1007/s00259-020-04746-6.
  • Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals.Wu J, Boutagy NE, Cai Z, Lin SF, Zheng MQ, Feher A, Stendahl JC, Kapinos M, Gallezot JD, Liu H, Mulnix T, Zhang W, Lindemann M, Teng JK, Miller EJ, Huang Y, Carson RE, Sinusas AJ, Liu C. Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2022, 29: 216-225. PMID: 32415628, PMCID: PMC7666654, DOI: 10.1007/s12350-020-02184-3.
  • Noise reduction with cross-tracer and cross-protocol deep transfer learning for low-dose PET.Liu H, Wu J, Lu W, Onofrey JA, Liu YH, Liu C. Noise reduction with cross-tracer and cross-protocol deep transfer learning for low-dose PET. Physics In Medicine And Biology 2020, 65: 185006. PMID: 32924973, DOI: 10.1088/1361-6560/abae08.
  • Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET.Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET. Physics In Medicine And Biology 2019, 64: 065002. PMID: 30695768, DOI: 10.1088/1361-6560/ab02c2.
  • Recent advances in cardiac SPECT instrumentation and imaging methods.Wu J, Liu C. Recent advances in cardiac SPECT instrumentation and imaging methods. Physics In Medicine And Biology 2019, 64: 06TR01. PMID: 30726779, DOI: 10.1088/1361-6560/ab04de.
  • An investigation of quantitative accuracy for deep learning based denoising in oncological PET.Lu W, Onofrey JA, Lu Y, Shi L, Ma T, Liu Y, Liu C. An investigation of quantitative accuracy for deep learning based denoising in oncological PET. Physics In Medicine And Biology 2019, 64: 165019. PMID: 31307019, DOI: 10.1088/1361-6560/ab3242.
  • Non-Rigid Event-by-Event Continuous Respiratory Motion Compensated List-Mode Reconstruction for PET.Chan C, Onofrey J, Jian Y, Germino M, Papademetris X, Carson RE, Liu C. Non-Rigid Event-by-Event Continuous Respiratory Motion Compensated List-Mode Reconstruction for PET. IEEE Transactions On Medical Imaging 2018, 37: 504-515. PMID: 29028189, PMCID: PMC7304524, DOI: 10.1109/TMI.2017.2761756.
  • Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT.Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn S, Zonouz TH, Liu YH, Lampert R, Sinusas AJ, Carson RE, Liu C. Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59: 1574-1580. PMID: 29476001, DOI: 10.2967/jnumed.117.202143.
  • Quantification of intramyocardial blood volume with 99mTc-RBC SPECT-CT imaging: A preclinical study.Mohy-Ud-Din H, Boutagy NE, Stendahl JC, Zhuang ZW, Sinusas AJ, Liu C. Quantification of intramyocardial blood volume with 99mTc-RBC SPECT-CT imaging: A preclinical study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25: 2096-2111. PMID: 28695406, PMCID: PMC5985225, DOI: 10.1007/s12350-017-0970-4.
  • Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data.Lu Y, Fontaine K, Mulnix T, Onofrey JA, Ren S, Panin V, Jones J, Casey ME, Barnett R, Kench P, Fulton R, Carson RE, Liu C. Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59: 1480-1486. PMID: 29439015, PMCID: PMC6126443, DOI: 10.2967/jnumed.117.203000.
  • Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose.Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose. Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.
  • Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT.Liu Q, Mohy-Ud-Din H, Boutagy N, Jiang M, Ren S, Stendahl J, Sinusas A, Liu C. Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Physics In Medicine And Biology 2017, 62: 3944-3957. PMID: 28266929, PMCID: PMC5568763, DOI: 10.1088/1361-6560/aa6520.
  • Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging.Yu Y, Chan C, Ma T, Liu Y, Gallezot JD, Naganawa M, Kelada OJ, Germino M, Sinusas AJ, Carson RE, Liu C. Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2016, 57: 1084-90. PMID: 26912437, DOI: 10.2967/jnumed.115.167676.
  • Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method.Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C. Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2016, 57: 1226-32. PMID: 27081169, DOI: 10.2967/jnumed.115.171710.
  • Noise suppressed partial volume correction for cardiac SPECT/CT.Chan C, Liu H, Grobshtein Y, Stacy MR, Sinusas AJ, Liu C. Noise suppressed partial volume correction for cardiac SPECT/CT. Medical Physics 2016, 43: 5225. PMID: 27587054, PMCID: PMC5001975, DOI: 10.1118/1.4961391.
  • The impact of system matrix dimension on small FOV SPECT reconstruction with truncated projections.Chan C, Dey J, Grobshtein Y, Wu J, Liu YH, Lampert R, Sinusas AJ, Liu C. The impact of system matrix dimension on small FOV SPECT reconstruction with truncated projections. Medical Physics 2016, 43: 213. PMID: 26745914, PMCID: PMC4691252, DOI: 10.1118/1.4938098.
  • Anatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT.Liu H, Chan C, Grobshtein Y, Ma T, Liu Y, Wang S, Stacy MR, Sinusas AJ, Liu C. Anatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT. Physics In Medicine And Biology 2015, 60: 6751-73. PMID: 26296043, PMCID: PMC4747118, DOI: 10.1088/0031-9155/60/17/6751.
  • Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators.Fan P, Hutton BF, Holstensson M, Ljungberg M, Hendrik Pretorius P, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics 2015, 42: 6895-911. PMID: 26632046, DOI: 10.1118/1.4934830.
  • End-expiration respiratory gating for a high-resolution stationary cardiac SPECT system.Chan C, Harris M, Le M, Biondi J, Grobshtein Y, Liu YH, Sinusas AJ, Liu C. End-expiration respiratory gating for a high-resolution stationary cardiac SPECT system. Physics In Medicine And Biology 2014, 59: 6267-87. PMID: 25256033, PMCID: PMC4528968, DOI: 10.1088/0031-9155/59/20/6267.
  • Is assessment of absolute myocardial perfusion with SPECT ready for prime time?Liu C, Sinusas AJ. Is assessment of absolute myocardial perfusion with SPECT ready for prime time? Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2014, 55: 1573-5. PMID: 25236351, DOI: 10.2967/jnumed.114.144550.
  • Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation.Chan C, Jin X, Fung EK, Naganawa M, Mulnix T, Carson RE, Liu C. Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation. Medical Physics 2013, 40: 112507. PMID: 24320466, DOI: 10.1118/1.4826165.
  • Respiratory motion correction for quantitative PET/CT using all detected events with internal-external motion correlation.Liu C, Alessio AM, Kinahan PE. Respiratory motion correction for quantitative PET/CT using all detected events with internal-external motion correlation. Medical Physics 2011, 38: 2715-23. PMID: 21776808, PMCID: PMC3107832, DOI: 10.1118/1.3582692.
  • Myocardial perfusion SPECT using a rotating multi-segment slant-hole collimator.Liu C, Xu J, Tsui BM. Myocardial perfusion SPECT using a rotating multi-segment slant-hole collimator. Medical Physics 2010, 37: 1610-8. PMID: 20443482, PMCID: PMC2852444, DOI: 10.1118/1.3310386.
  • Quiescent period respiratory gating for PET/CT.Liu C, Alessio A, Pierce L, Thielemans K, Wollenweber S, Ganin A, Kinahan P. Quiescent period respiratory gating for PET/CT. Medical Physics 2010, 37: 5037-43. PMID: 20964223, PMCID: PMC2945743, DOI: 10.1118/1.3480508.
  • The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging.Liu C, Pierce LA, Alessio AM, Kinahan PE. The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging. Physics In Medicine And Biology 2009, 54: 7345-62. PMID: 19926910, PMCID: PMC2895622, DOI: 10.1088/0031-9155/54/24/007.
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