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Charles Duncan, MD, FAANS

Senior Research Scientist

Contact Information

Charles Duncan, MD, FAANS

Mailing Address

  • Neurosurgery

    PO Box 208082

    New Haven, CT 06520-8082

    United States

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Yale Medicine

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Research Summary

Development of cerebral blood flow measurement systems for immature brain by positron emission tomography, the prevention of intraventricular and germinal matrix hemorrhage in the premature infant by basic and multicenter clinical trials, basic investigations into the adaptive mechanisms of developing brain to injury, and the development of endoscopic surgery in the very young.

Specialized Terms: Adaptation of the developing brain to injury

Extensive Research Description

Dr. Duncan's research activities have included the development of cerebral blood flow measurement systems for immature brain by positron emission tomography, the prevention of intraventricular and germinal matrix hemorrhage in the premature infant by basic and multicenter clinical trials, basic investigations into the adaptive mechanisms of developing brain to injury, and the development of endoscopic surgery in the very young

Coauthors

Research Interests

Brain Injuries; Cerebral Arteries; Infant; Neurosurgery; Pediatrics

Selected Publications

  • Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 2020, 26: 1754-1765. PMID: 33077954, PMCID: PMC7871900, DOI: 10.1038/s41591-020-1090-2.
  • Long-Term Neurocognitive Outcomes in Sagittal Synostosis: The Impact of Reoperation.Chuang C, Chaunzwa TL, Wu R, Singh A, Patel A, Yang JF, Hashim PW, Travieso R, Terner JS, Mayes LC, Duncan CC, Jane JA, Lin KY, Bridgett DJ, Persing JA. Long-Term Neurocognitive Outcomes in Sagittal Synostosis: The Impact of Reoperation. The Journal Of Craniofacial Surgery 2021, 32: 58-61. PMID: 33394632, DOI: 10.1097/SCS.0000000000006909.
  • Functional Network Development in Sagittal Craniosynostosis Treated With Whole Vault Cranioplasty.Cabrejo R, Lacadie C, Sun A, Chuang C, Yang J, Brooks E, Beckett J, Eilbott J, Gabrick K, Steinbacher D, Duncan C, DiLuna M, Alperovich M, Pelphrey K, Ventola P, Constable T, Persing JA. Functional Network Development in Sagittal Craniosynostosis Treated With Whole Vault Cranioplasty. The Journal Of Craniofacial Surgery 2021, 32: 1721-1726. PMID: 33534301, DOI: 10.1097/SCS.0000000000007505.
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