Catherine Dinauer, MD
Associate Professor of Clinical Pediatrics (Endocrinology)
Research & Publications
Biography
News
Locations
Research Summary
I currently work with pediatric surgery on questions related to management and outcomes of children with papillary thyroid cancer using a retrospective database. Our group is part of the multi-institutional Child and Adolescent Thyroid Consortium, newly established in 2020. I have worked in collaboration with pediatric and endocrine surgery on clinical outcomes after definitive therapy for Graves disease in children and with endocrine pathology on molecular analysis of pediatric papillary thyroid carcinoma and correlation with clinical phenotypes and outcomes.
Coauthors
Research Interests
Carcinoma, Papillary; Congenital Hypothyroidism; Graves Disease; Hyperthyroidism; Pediatrics; Thyroid Gland; Thyroid Neoplasms
Selected Publications
- Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice.Rubinstein JC, Herrick-Reynolds K, Dinauer C, Morotti R, Solomon D, Callender GG, Christison-Lagay ER. Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice. The Journal Of Surgical Research 2020, 249: 58-66. PMID: 31923715, DOI: 10.1016/j.jss.2019.12.002.
- Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature.Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB. Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. Journal Of Clinical Neuroscience : Official Journal Of The Neurosurgical Society Of Australasia 2020, 78: 420-422. PMID: 32336638, DOI: 10.1016/j.jocn.2020.04.103.
- Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee.Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis GL, Malek MM, Lautz TB, Aldrink JH, Grant C, Rhee DS, Ehrlich P, Dasgupta R, Abdessalam S. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.
- Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients.Darbinyan A, Morotti R, Cai G, Prasad ML, Christison-Lagay E, Dinauer C, Adeniran AJ. Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients. Cancer Cytopathology 2020, 128: 746-756. PMID: 32897650, DOI: 10.1002/cncy.22329.
- Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer.Rubinstein JC, Dinauer C, Herrick-Reynolds K, Morotti R, Callender GG, Christison-Lagay ER. Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer. Journal Of Pediatric Surgery 2019, 54: 129-132. PMID: 30361076, DOI: 10.1016/j.jpedsurg.2018.10.010.
- Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium.Clement SC, Kremer LCM, Verburg FA, Simmons JH, Goldfarb M, Peeters RP, Alexander EK, Bardi E, Brignardello E, Constine LS, Dinauer CA, Drozd VM, Felicetti F, Frey E, Heinzel A, van den Heuvel-Eibrink MM, Huang SA, Links TP, Lorenz K, Mulder RL, Neggers SJ, Nieveen van Dijkum EJM, Oeffinger KC, van Rijn RR, Rivkees SA, Ronckers CM, Schneider AB, Skinner R, Wasserman JD, Wynn T, Hudson MM, Nathan PC, van Santen HM. Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium. Cancer Treatment Reviews 2018, 63: 28-39. PMID: 29202445, DOI: 10.1016/j.ctrv.2017.11.005.
- Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma.Hardee S, Prasad ML, Hui P, Dinauer CA, Morotti RA. Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma. Pediatric And Developmental Pathology : The Official Journal Of The Society For Pediatric Pathology And The Paediatric Pathology Society 2017, 20: 206-212. PMID: 28521635, DOI: 10.1177/1093526616689628.
- NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States.Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016, 122: 1097-107. PMID: 26784937, DOI: 10.1002/cncr.29887.
- C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain.Abi-Raad R, Virk RK, Dinauer CA, Prasad A, Morotti RA, Breuer CK, Sosa JA, Udelsman R, Rivkees SA, Prasad ML. C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain. Human Pathology 2015, 46: 1121-8. PMID: 26033033, DOI: 10.1016/j.humpath.2015.04.011.
- Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid : Official Journal Of The American Thyroid Association 2015, 25: 716-59. PMID: 25900731, PMCID: PMC4854274, DOI: 10.1089/thy.2014.0460.
- Differentiated thyroid cancer in childrenin Clinical Management of Thyroid Cancer, ed. Kakudo K and Liu Z, Future Medicine, London, UK, 2013, pp 106-118 (e-book).
- The treatment of differentiated thyroid cancer in children: emphasis on surgical approach and radioactive iodine therapy.Rivkees SA, Mazzaferri EL, Verburg FA, Reiners C, Luster M, Breuer CK, Dinauer CA, Udelsman R. The treatment of differentiated thyroid cancer in children: emphasis on surgical approach and radioactive iodine therapy. Endocrine Reviews 2011, 32: 798-826. PMID: 21880704, PMCID: PMC3591676, DOI: 10.1210/er.2011-0011.
- Adverse events associated with methimazole therapy of graves' disease in children.Rivkees SA, Stephenson K, Dinauer C. Adverse events associated with methimazole therapy of graves' disease in children. International Journal Of Pediatric Endocrinology 2010, 2010: 176970. PMID: 20224800, PMCID: PMC2833412, DOI: 10.1155/2010/176970.
- The Use of 131-Iodine in the Treatment of Graves Disease in Childrenin Comprehensive Handbook of Iodine: Nutritional, Endocrine, and Pathological Aspects, ed. Preedy VR, Burrow GN, and Watson RR, Elsevier Inc., Oxford, UK, 2009, pp 943-955.
- Differentiated thyroid cancer in children: diagnosis and management.Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management. Current Opinion In Oncology 2008, 20: 59-65. PMID: 18043257, DOI: 10.1097/CCO.0b013e3282f30220.
- Thyroid cancer in children.Dinauer C, Francis GL. Thyroid cancer in children. Endocrinology And Metabolism Clinics Of North America 2007, 36: 779-806, vii. PMID: 17673128, DOI: 10.1016/j.ecl.2007.04.002.
- An optimal treatment for pediatric Graves' disease is radioiodine.Rivkees SA, Dinauer C. An optimal treatment for pediatric Graves' disease is radioiodine. The Journal Of Clinical Endocrinology And Metabolism 2007, 92: 797-800. PMID: 17341574, DOI: 10.1210/jc.2006-1239.
- The MACIS score predicts the clinical course of papillary thyroid carcinoma in children and adolescents.Powers PA, Dinauer CA, Tuttle RM, Francis GL. The MACIS score predicts the clinical course of papillary thyroid carcinoma in children and adolescents. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2004, 17: 339-43. PMID: 15112910, DOI: 10.1515/jpem.2004.17.3.339.
- Tumor size and extent of disease at diagnosis predict the response to initial therapy for papillary thyroid carcinoma in children and adolescents.Powers PA, Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Tumor size and extent of disease at diagnosis predict the response to initial therapy for papillary thyroid carcinoma in children and adolescents. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2003, 16: 693-702. PMID: 12880118, DOI: 10.1515/jpem.2003.16.5.693.
- Treatment of recurrent papillary thyroid carcinoma in children and adolescents.Powers PA, Dinauer CA, Tuttle RM, Francis GL. Treatment of recurrent papillary thyroid carcinoma in children and adolescents. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2003, 16: 1033-40. PMID: 14513881, DOI: 10.1515/jpem.2003.16.7.1033.
- Intense expression of the b7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescents.Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Intense expression of the b7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescents. The Journal Of Clinical Endocrinology And Metabolism 2002, 87: 4391-7. PMID: 12213904, DOI: 10.1210/jc.2002-011262.
- Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents.Patel A, Jhiang S, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents. Pediatric Research 2002, 52: 737-44. PMID: 12409522, DOI: 10.1203/00006450-200211000-00021.
- Infiltration of differentiated thyroid carcinoma by proliferating lymphocytes is associated with improved disease-free survival for children and young adults.Gupta S, Patel A, Folstad A, Fenton C, Dinauer CA, Tuttle RM, Conran R, Francis GL. Infiltration of differentiated thyroid carcinoma by proliferating lymphocytes is associated with improved disease-free survival for children and young adults. The Journal Of Clinical Endocrinology And Metabolism 2001, 86: 1346-54. PMID: 11238531, DOI: 10.1210/jcem.86.3.7310.
- Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults.Patel A, Fenton C, Ramirez R, Dinauer CA, Tuttle RM, Nikiforov YE, Gary FL. Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults. Frontiers In Bioscience : A Journal And Virtual Library 2000, 5: A1-9. PMID: 10702379, DOI: 10.2741/patel.
- The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults.Fenton CL, Lukes Y, Nicholson D, Dinauer CA, Francis GL, Tuttle RM. The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. The Journal Of Clinical Endocrinology And Metabolism 2000, 85: 1170-5. PMID: 10720057, DOI: 10.1210/jcem.85.3.6472.
- Ras mutations are uncommon in sporadic thyroid cancer in children and young adults.Fenton C, Anderson J, Lukes Y, Dinauer CA, Tuttle RM, Francis GL. Ras mutations are uncommon in sporadic thyroid cancer in children and young adults. Journal Of Endocrinological Investigation 1999, 22: 781-9. PMID: 10614528, DOI: 10.1007/BF03343644.
- Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma.Welch Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma. Journal Of Pediatric Surgery 1999, 34: 1799-804. PMID: 10626858, DOI: 10.1016/s0022-3468(99)90316-0.
- The impact of initial surgical management on outcome in young patients with differentiated thyroid cancer.Robie DK, Dinauer CW, Tuttle RM, Ward DT, Parry R, McClellan D, Svec R, Adair C, Francis G. The impact of initial surgical management on outcome in young patients with differentiated thyroid cancer. Journal Of Pediatric Surgery 1998, 33: 1134-8; discussion 1139-40. PMID: 9694109, DOI: 10.1016/s0022-3468(98)90546-2.
- Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults.Welch Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Svec RL, Adair C, Francis GL. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clinical Endocrinology 1998, 49: 619-28. PMID: 10197078, DOI: 10.1046/j.1365-2265.1998.00584.x.
- Management of Pediatric Graves Disease: A Review.Quintanilla-Dieck L, Khalatbari HK, Dinauer CA, Rastatter JC, Chelius DC, Katowitz WR, Shindo ML, Parisi MT, Kazahaya K. Management of Pediatric Graves Disease: A Review. JAMA Otolaryngology-- Head & Neck Surgery 2021, 147: 1110-1118. PMID: 34647991, DOI: 10.1001/jamaoto.2021.2715.
- Treatment of hypothyroidism in infants, children and adolescents.Rodriguez L, Dinauer C, Francis G. Treatment of hypothyroidism in infants, children and adolescents. Trends In Endocrinology And Metabolism: TEM 2022, 33: 522-532. PMID: 35537910, DOI: 10.1016/j.tem.2022.04.007.