Research & Publications
The Lucas laboratory uses human genomics, cellular and molecular immunology, and mouse modeling to elucidate new immunology principles relevant for human disease. Our studies begin with patients suffering from inherited immune disorders and utilize various approaches to uncover the genetic and biochemical defects responsible for disease with the goal of applying this knowledge not only to devise targeted therapies for rare disorders but also to more generally dissect basic pathways critical for healthy immune function. A major current focus of the lab is on phosphoinositide 3-kinase (PI3K) signaling and mechanisms of disease in patients with inherited mutations in PI3K subunits.
Immunologic Deficiency Syndromes; Immunoproliferative Disorders; Inflammation; T-Lymphocytes; Signal Transduction; Hereditary Autoinflammatory Diseases