Caroline Hendry, PhD
Scientific Director and Advisor to the Chair
Research & Publications
Biography
News
Research Summary
My personal research interest is in understanding the genetic basis of development and disease. I completed my graduate studies in kidney developmental biology where my thesis focused on the forced reprogramming of adult human kidney cells to a nephron progenitor-like population. My postdoctoral work expanded the principle of reprogramming to other cell types, including hematopoietic progenitor cells, as well as induced pluripotent stem cells for disease modeling. At Yale, my research efforts focus on understanding the fundamental cellular and molecular principles that govern successful reproduction, early embryogenesis and subsequent developmental processes.
Coauthors
Selected Publications
- The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activationMiao L, Tang Y, Bonneau AR, Chan SH, Kojima ML, Pownall ME, Vejnar CE, Gao F, Krishnaswamy S, Hendry CE, Giraldez AJ. The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell 2022, 82: 986-1002.e9. PMID: 35182480, PMCID: PMC9327391, DOI: 10.1016/j.molcel.2022.01.024.
- Prdm6 controls heart development by regulating neural crest cell differentiation and migrationHong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight 2022, 7: e156046. PMID: 35108221, PMCID: PMC8876496, DOI: 10.1172/jci.insight.156046.
- Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D'Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MYR, Zhu K, Wang S, Roussos P, Schadt EE, Pandey G, Chang R, Quertermous T, Lemischka I. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell 2017, 20: 518-532.e9. PMID: 28017796, DOI: 10.1016/j.stem.2016.11.005.
- Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors.Hendry CE, Vanslambrouck JM, Ineson J, Suhaimi N, Takasato M, Rae F, Little MH. Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. Journal Of The American Society Of Nephrology : JASN 2013, 24: 1424-34. PMID: 23766537, PMCID: PMC3752949, DOI: 10.1681/ASN.2012121143.
- Induction of a hemogenic program in mouse fibroblasts.Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma'ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell 2013, 13: 205-18. PMID: 23770078, PMCID: PMC3735774, DOI: 10.1016/j.stem.2013.05.024.
- Reprogramming the kidney: a novel approach for regeneration.Hendry CE, Little MH. Reprogramming the kidney: a novel approach for regeneration. Kidney International 2012, 82: 138-46. PMID: 22437414, DOI: 10.1038/ki.2012.68.
- Defining and redefining the nephron progenitor population.Hendry C, Rumballe B, Moritz K, Little MH. Defining and redefining the nephron progenitor population. Pediatric Nephrology (Berlin, Germany) 2011, 26: 1395-406. PMID: 21229268, PMCID: PMC3189495, DOI: 10.1007/s00467-010-1750-4.
- Stem cell options for kidney disease.Hopkins C, Li J, Rae F, Little MH. Stem cell options for kidney disease. J Pathol 2009, 217: 265-81. PMID: 19058290, DOI: 10.1002/path.2477.