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Brian B. Koo, MD

Associate Professor; Director, Sleep Medicine Laboratory at Connecticut Veterans Affairs Healthcare System, Medicine; Director, Yale Center for Restless Legs Syndrome

Contact Information

Brian B. Koo, MD

Mailing Address

  • Neurology

    PO Box 208018

    New Haven, CT 06520-8018

    United States

Research Summary

My main research interests lie in the intersection between neurology and sleep medicine. My current area of focus is on the restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) and their association with cardiovascular disease. We have compiled epidemiologic evidence that PLMS is associated with the development of cardiovascular disease such as myocardial infarction, peripheral vascular disease and stroke. We are learning from additional studies that hypertension may play a role in this association. I am currently interested in taking a closer look at the sleep physiology in individuals with RLS and PLMS, inspecting specific time domain elements of these limb movements as well as heart rate and breathing. In addition to this vein of research, I have completed work on an animal model of RLS and am currently investigating the human genetics related to this troubling disorder.

Specialized Terms: Restless Legs Syndrome; Periodic Limb Movements During Sleep; Obstructive Sleep Apnea and Stroke

Coauthors

Research Interests

Neurology; Restless Legs Syndrome; Sleep; Veterans; Sleep Apnea, Obstructive; Stroke

Selected Publications

Clinical Trials

ConditionsStudy Title
Diseases of the Nervous SystemRestless Legs Syndrome: The Role of Melanocortin Hormones