Brian Coon, PhD

• Daniela Tirziu
• Federico Corti
• Jean-Leon Thomas
• Jiasheng Zhang
• Martin Schwartz
• Michael Simons

Cardiovascular Physiological Phenomena; Cell Adhesion; Cell Physiological Phenomena; Hemodynamics; Signal Transduction; Cell Polarity

Cardiovascular Diseases

• Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specificationFang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification Nature Communications 2017, 8: 2149. PMID: 29247167, PMCID: PMC5732288, DOI: 10.1038/s41467-017-01742-7.
• VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGNConway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN Current Biology 2017, 27: 2727. PMID: 28898639, PMCID: PMC5752114, DOI: 10.1016/j.cub.2017.08.064.
• VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGNConway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN Current Biology 2017, 27: 2219-2225.e5. PMID: 28712573, PMCID: PMC5667920, DOI: 10.1016/j.cub.2017.06.020.
• Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic developmentWang Y, Baeyens N, Corti F, Tanaka K, Fang J, Zhang J, Jin Y, Coon B, Hirschi K, Schwartz M, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development Journal Of Cell Science 2016, 129: e1.1-e1.1. DOI: 10.1242/jcs.200089.
• Endothelial fluid shear stress sensing in vascular health and diseaseBaeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease Journal Of Clinical Investigation 2016, 126: 821-828. PMID: 26928035, PMCID: PMC4767335, DOI: 10.1172/jci83083.
• Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complexCoon B, Baeyens N, Han J, Budatha M, Ross T, Fang J, Yun S, Thomas J, Schwartz M. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex The Journal Of General Physiology 2015, 145: 1454oia13. DOI: 10.1085/jgp.1454oia13.
• Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complexCoon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL, Schwartz MA. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex Journal Of Cell Biology 2015, 208: 975-986. PMID: 25800053, PMCID: PMC4384728, DOI: 10.1083/jcb.201408103.
• Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set pointBaeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA. Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point ELife 2015, 4: e04645. PMID: 25643397, PMCID: PMC4337723, DOI: 10.7554/elife.04645.
• Integrins in mechanotransductionRoss TD, Coon BG, Yun S, Baeyens N, Tanaka K, Ouyang M, Schwartz MA. Integrins in mechanotransduction Current Opinion In Cell Biology 2013, 25: 613-618. PMID: 23797029, PMCID: PMC3757118, DOI: 10.1016/j.ceb.2013.05.006.
• The Lowe syndrome protein OCRL1 is involved in primary cilia assemblyHernandez V, Coon B, Madhivanan K, Mukherjee D, Hanna C, Barinaga-Rementeria Ramirez I, Lowe M, Beales P, Aguilar R. The Lowe syndrome protein OCRL1 is involved in primary cilia assembly Cilia 2012, 1: p87. PMCID: PMC3555894, DOI: 10.1186/2046-2530-1-s1-p87.
• Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and BranchingTirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and Branching Circulation 2012, 126: 2589-2600. PMID: 23091063, PMCID: PMC3514045, DOI: 10.1161/circulationaha.112.119321.
• The Lowe syndrome protein OCRL1 is involved in primary cilia assemblyCoon BG, Hernandez V, Madhivanan K, Mukherjee D, Hanna CB, Ramirez I, Lowe M, Beales PL, Aguilar RC. The Lowe syndrome protein OCRL1 is involved in primary cilia assembly Human Molecular Genetics 2012, 21: 1835-1847. PMID: 22228094, DOI: 10.1093/hmg/ddr615.
• JNK2 Promotes Endothelial Cell Alignment under FlowHahn C, Wang C, Orr AW, Coon BG, Schwartz MA. JNK2 Promotes Endothelial Cell Alignment under Flow PLOS ONE 2011, 6: e24338. PMID: 21909388, PMCID: PMC3164210, DOI: 10.1371/journal.pone.0024338.
• Epsins’ novel role in cancer cell invasionCoon B, DiRenzo D, Konieczny S, Aguilar R. Epsins’ novel role in cancer cell invasion Communicative & Integrative Biology 2011, 4: 95-97. DOI: 10.4161/cib.14129.
• The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathwayMukherjee D, Coon B, Edwards D, Hanna C, Longhi S, McCaffery J, Wendland B, Retegui L, Bi E, Aguilar R. The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway Journal Of Cell Science 2009, 122: 2782-2782. PMCID: PMC2777996, DOI: 10.1242/jcs.057349.