Brenda Cabrera-Mendoza, MD/PhD

• Daniel Jacoby
• David Glahn
• Edward J Miller
• Guido Falcone
• Joel Gelernter
• John Krystal
• José Jaime Martínez-Magaña
• Laura Huckins
• Renato Polimanti
• Robert Pietrzak

Suicide; Substance-Related Disorders; Psychiatry and Psychology

• The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study.Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. International Journal Of Epidemiology 2022 PMID: 35751636, PMCID: PMC9278255, DOI: 10.1093/ije/dyac129.
• The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression.Pathak GA, De Lillo A, Wendt FR, De Angelis F, Koller D, Cabrera Mendoza B, Jacoby D, Miller EJ, Buxbaum JN, Polimanti R. The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression. Amyloid : The International Journal Of Experimental And Clinical Investigation : The Official Journal Of The International Society Of Amyloidosis 2022, 29: 110-119. PMID: 34935565, PMCID: PMC9213571, DOI: 10.1080/13506129.2021.2018678.
• Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder.Wendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.
• Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits.Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O' Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
• Epigenome-Wide Analysis Reveals DNA Methylation Alteration in ZFP57 and Its Target RASGFR2 in a Mexican Population Cohort with Autism.Aspra Q, Cabrera-Mendoza B, Morales-Marín ME, Márquez C, Chicalote C, Ballesteros A, Aguilar M, Castro X, Gómez-Cotero A, Balboa-Verduzco AM, Albores-Gallo L, Nafate-López O, Marcín-Salazar CA, Sánchez P, Lanzagorta-Piñol N, López-Armenta FO, Nicolini H. Epigenome-Wide Analysis Reveals DNA Methylation Alteration in ZFP57 and Its Target RASGFR2 in a Mexican Population Cohort with Autism. Children (Basel, Switzerland) 2022, 9 PMID: 35455506, PMCID: PMC9025761, DOI: 10.3390/children9040462.
• Candidate pharmacological treatments for substance use disorder and suicide identified by gene co-expression network-based drug repositioning.Cabrera-Mendoza B, Martínez-Magaña JJ, Monroy-Jaramillo N, Genis-Mendoza AD, Fresno C, Fries GR, Walss-Bass C, López Armenta M, García-Dolores F, Díaz-Otañez CE, Flores G, Vázquez-Roque RA, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co-expression network-based drug repositioning. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.
• A meta-study on transcription factor networks in the suicidal brain.Cabrera-Mendoza B, de Anda-Jáuregui G, Nicolini H, Fresno C. A meta-study on transcription factor networks in the suicidal brain. Journal Of Psychiatric Research 2021, 136: 23-31. PMID: 33548827, DOI: 10.1016/j.jpsychires.2021.01.037.
• Brain Gene Expression Profiling of Individuals With Dual Diagnosis Who Died by Suicide.Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Díaz-Otañez CE, García-Dolores F, González-Sáenz EE, Mendoza-Morales RC, Flores G, Vázquez-Roque R, Nicolini H. Brain Gene Expression Profiling of Individuals With Dual Diagnosis Who Died by Suicide. Journal Of Dual Diagnosis 2020, 16: 177-190. PMID: 31774731, DOI: 10.1080/15504263.2019.1692160.
• Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers.Rodríguez-López ML, Martínez-Magaña JJ, Cabrera-Mendoza B, Genis-Mendoza AD, García-Dolores F, López-Armenta M, Flores G, Vázquez-Roque RA, Nicolini H. Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2020, 183: 26-37. PMID: 31418530, DOI: 10.1002/ajmg.b.32752.
• High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior.Cabrera-Mendoza B, Martínez-Magaña JJ, Genis-Mendoza AD, Sarmiento E, Ruíz-Ramos D, Tovilla-Zárate CA, González-Castro TB, Juárez-Rojop IE, García-de la Cruz DD, López-Armenta M, Real F, García-Dolores F, Flores G, Vázquez-Roque RA, Lanzagorta N, Escamilla M, Saucedo-Uribe E, Rodríguez-Mayoral O, Jiménez-Genchi J, Castañeda-González C, Roche-Bergua A, Nicolini H. High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior. Journal Of Psychiatric Research 2020, 123: 62-71. PMID: 32036075, DOI: 10.1016/j.jpsychires.2020.01.008.
• Sex differences in brain gene expression among suicide completers.Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Mendoza-Morales RC, García-Dolores F, Díaz-Otañez CE, González-Sáenz EE, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Flores G, Vázquez-Roque RA, Nicolini H. Sex differences in brain gene expression among suicide completers. Journal Of Affective Disorders 2020, 267: 67-77. PMID: 32063575, DOI: 10.1016/j.jad.2020.01.167.
• Brain Gene Expression-DNA Methylation Correlation in Suicide Completers: Preliminary Results.Cabrera-Mendoza B, Martínez-Magaña JJ, Genis-Mendoza AD, Monroy-Jaramillo N, Walss-Bass C, Fries GR, García-Dolores F, López-Armenta M, Flores G, Vázquez-Roque RA, Nicolini H. Brain Gene Expression-DNA Methylation Correlation in Suicide Completers: Preliminary Results. Revista De Investigacio´n Cli´nica; Organo Del Hospital De Enfermedades De La Nutricio´n 2020, 72: 283-292. PMID: 33057323, DOI: 10.24875/RIC.19003250.
• Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder.Cabrera B, Monroy-Jaramillo N, Fries GR, Mendoza-Morales RC, García-Dolores F, Mendoza-Larios A, Diaz-Otañez C, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Fresno C, Nicolini H. Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder. Molecular Neuropsychiatry 2019, 5: 60-73. PMID: 31019919, PMCID: PMC6465692, DOI: 10.1159/000493940.
• Neuroanatomical features and its usefulness in classification of patients with PANDAS.Cabrera B, Romero-Rebollar C, Jiménez-Ángeles L, Genis-Mendoza AD, Flores J, Lanzagorta N, Arroyo M, de la Fuente-Sandoval C, Santana D, Medina-Bañuelos V, Sacristán E, Nicolini H. Neuroanatomical features and its usefulness in classification of patients with PANDAS. CNS Spectrums 2019, 24: 533-543. PMID: 30428956, DOI: 10.1017/S1092852918001268.