Basavaraju Sanganahalli, PhD
Associate Research Scientist in Radiology and Biomedical Imaging
Research & Publications
Biography
News
Research Summary
We do not yet understand exactly how the brain processes sensory information. Functional magnetic resonance imaging ( fMRI) is currently the most widely used method for brain mapping since it is completely non-invasive and provides high spatial and temporal resolution. I am currently using fMRI and electrophysiological techniques to understand the relationship between neuronal activity and the hemodynamic response which is the basis of BOLD (fMRI) signal.
Coauthors
Selected Publications
- Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI.Sanganahalli BG, Baker KL, Thompson GJ, Herman P, Shepherd GM, Verhagen JV, Hyder F. Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. NeuroImage 2020, 212: 116664. PMID: 32087375, DOI: 10.1016/j.neuroimage.2020.116664.
- APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease.Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiology Of Disease 2020, 139: 104834. PMID: 32173556, PMCID: PMC7486698, DOI: 10.1016/j.nbd.2020.104834.
- Association Between Magnetic Resonance Imaging-Based Spinal Morphometry and Sensorimotor Behavior in a Hemicontusion Model of Incomplete Cervical Spinal Cord Injury in Rats.Chitturi J, Sanganahalli BG, Herman P, Hyder F, Ni L, Elkabes S, Heary R, Kannurpatti SS. Association Between Magnetic Resonance Imaging-Based Spinal Morphometry and Sensorimotor Behavior in a Hemicontusion Model of Incomplete Cervical Spinal Cord Injury in Rats. Brain Connectivity 2020, 10: 479-489. PMID: 32981350, PMCID: PMC7698856, DOI: 10.1089/brain.2020.0812.
- Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping.Sanganahalli BG, Rebello MR, Herman P, Papademetris X, Shepherd GM, Verhagen JV, Hyder F. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. NeuroImage 2016, 126: 208-18. PMID: 26631819, PMCID: PMC4733588, DOI: 10.1016/j.neuroimage.2015.11.048.
- Metabolic demands of neural-hemodynamic associated and disassociated areas in brain.Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2016, 36: 1695-1707. PMID: 27562867, PMCID: PMC5076793, DOI: 10.1177/0271678X16664531.
- Functional MRI and neural responses in a rat model of Alzheimer's disease.Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-11. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.
- Oxidative neuroenergetics in event-related paradigms.Sanganahalli BG, Herman P, Blumenfeld H, Hyder F. Oxidative neuroenergetics in event-related paradigms. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2009, 29: 1707-18. PMID: 19211878, PMCID: PMC2760964, DOI: 10.1523/JNEUROSCI.5549-08.2009.
- Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI.Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI. PloS One 2013, 8: e63317. PMID: 23650561, PMCID: PMC3641133, DOI: 10.1371/journal.pone.0063317.
- Mitochondrial calcium uptake capacity modulates neocortical excitability.Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial calcium uptake capacity modulates neocortical excitability. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2013, 33: 1115-26. PMID: 23591650, PMCID: PMC3705442, DOI: 10.1038/jcbfm.2013.61.
- Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents.Sanganahalli BG, Bailey CJ, Herman P, Hyder F. Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents. Methods In Molecular Biology (Clifton, N.J.) 2009, 489: 213-42. PMID: 18839094, PMCID: PMC3703391, DOI: 10.1007/978-1-59745-543-5_10.
- Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI.Herman P, Sanganahalli BG, Blumenfeld H, Rothman DL, Hyder F. Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15115-20. PMID: 23980158, PMCID: PMC3773779, DOI: 10.1073/pnas.1307154110.
- Analysis of time and space invariance of BOLD responses in the rat visual system.Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F. Analysis of time and space invariance of BOLD responses in the rat visual system. Cerebral Cortex (New York, N.Y. : 1991) 2013, 23: 210-22. PMID: 22298731, PMCID: PMC3513959, DOI: 10.1093/cercor/bhs008.
- Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms.Hyder F, Sanganahalli BG, Herman P, Coman D, Maandag NJ, Behar KL, Blumenfeld H, Rothman DL. Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms. Frontiers In Neuroenergetics 2010, 2 PMID: 20838476, PMCID: PMC2936934, DOI: 10.3389/fnene.2010.00018.
- Multimodal measurements of blood plasma and red blood cell volumes during functional brain activation.Herman P, Sanganahalli BG, Hyder F. Multimodal measurements of blood plasma and red blood cell volumes during functional brain activation. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2009, 29: 19-24. PMID: 18766196, PMCID: PMC2714270, DOI: 10.1038/jcbfm.2008.100.
- Negative BOLD with large increases in neuronal activity.Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H. Negative BOLD with large increases in neuronal activity. Cerebral Cortex (New York, N.Y. : 1991) 2008, 18: 1814-27. PMID: 18063563, PMCID: PMC2790390, DOI: 10.1093/cercor/bhm208.
- Frequency-dependent tactile responses in rat brain measured by functional MRI.Sanganahalli BG, Herman P, Hyder F. Frequency-dependent tactile responses in rat brain measured by functional MRI. NMR In Biomedicine 2008, 21: 410-6. PMID: 18435491, PMCID: PMC2774500, DOI: 10.1002/nbm.1259.
- Energetics of neuronal signaling and fMRI activity.Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F. Energetics of neuronal signaling and fMRI activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20546-51. PMID: 18079290, PMCID: PMC2154468, DOI: 10.1073/pnas.0709515104.