Research & Publications
I finished my Ph.D. after investigating the role of NMDAR mediated synaptic plasticity and metaplasticity in early odor preference learning. At the same time, I got involved in a project to establish a model of Alzheimer's disease (AD). In that project, I gathered a lot of information regarding the role of the Locus coeruleus and tau hyperphosphorylation in AD. After I left the lab I joined another lab where I started working on hippocampal synaptic plasticity. My main interest was to look into the dichotomy of synaptic plasticity along the hippocampal longitudinal axis. I also investigated the differential expression of different subunits of NMDAR. and how that affects synaptic plasticity, calcium permeability and also glutamate dynamics along the hippocampal dorsoventral axis.
At Yale, I will be working on the molecular basis of neurodegeneration. This is likely to include both Alzheimer’s and Fronto-Temporal dementia models in mice. Experiments will utilize both pharmacological and genetic interventions to modulate the disease course in preclinical models. Techniques will include histology, memory testing, electrophysiology, and molecular biochemistry.
Synaptic Transmission; Neuronal Plasticity; Stress Disorders, Post-Traumatic; Receptors, Presynaptic; Neurodegenerative Diseases