Bal Krishna Chaube
Associate Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesisChaube B, Citrin K, Sahraei M, Singh A, de Urturi D, Ding W, Pierce R, Raaisa R, Cardone R, Kibbey R, Fernández-Hernando C, Suárez Y. Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis. Nature Communications 2023, 14: 8251. PMID: 38086791, PMCID: PMC10716292, DOI: 10.1038/s41467-023-43900-0.
- Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in miceSingh AK, Chaube B, Zhang X, Sun J, Citrin KM, Canfrán-Duque A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price N, Suárez Y, Fernandez-Hernando C. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. Journal Of Clinical Investigation 2021, 131 PMID: 34255741, PMCID: PMC8409581, DOI: 10.1172/jci140989.
- AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesisChaube B, Malvi P, Singh S, Mohammad N, Viollet B, Bhat M. AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis. Cell Death Discovery 2015, 1: 15063. PMID: 27551487, PMCID: PMC4979508, DOI: 10.1038/cddiscovery.2015.63.
- Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in miceBoutagy N, Gamez-Mendez A, Fowler J, Zhang H, Chaube B, Esplugues E, Kuo A, Lee S, Horikami D, Zhang J, Citrin K, Singh A, Coon B, Lee M, Suarez Y, Fernandez-Hernando C, Sessa W. Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. Journal Of Clinical Investigation 2024, 134: e170453. PMID: 38175710, PMCID: PMC10866653, DOI: 10.1172/jci170453.
- Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma.Singh AK, Chaube B, Citrin KM, Fowler JW, Lee S, Catarino J, Knight J, Lowery S, Shree S, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross TT, Malaker S, Suárez Y, Fernández-Hernando C, Grabinska K, Sessa WC. Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma. BioRxiv 2023 PMID: 38014178, DOI: 10.1101/2023.11.13.566870.
- Editorial: Cancer metabolism: molecular insights, metabolic crosstalk in the tumor microenvironment, and implications for therapyChaube B, Malvi P. Editorial: Cancer metabolism: molecular insights, metabolic crosstalk in the tumor microenvironment, and implications for therapy. Frontiers In Oncology 2023, 13: 1289397. PMID: 37799477, PMCID: PMC10548817, DOI: 10.3389/fonc.2023.1289397.
- Abstract 265: Coronavirus Infection Induced Interferon Signaling Promotes Atherosclerotic Plaque VulnerabilityZhang H, Zhang X, Jovin D, Sun J, Chaube B, Esplugues E, Suarez Y, Fernandez-Hernando C. Abstract 265: Coronavirus Infection Induced Interferon Signaling Promotes Atherosclerotic Plaque Vulnerability. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43 DOI: 10.1161/atvb.43.suppl_1.265.
- TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalkBhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes‐Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk. The FASEB Journal 2022, 36: e22185. PMID: 35133032, PMCID: PMC9624374, DOI: 10.1096/fj.202101607r.
- MMAB promotes negative feedback control of cholesterol homeostasisGoedeke L, Canfrán-Duque A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasunción MA, Suárez Y, Fernández-Hernando C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications 2021, 12: 6448. PMID: 34750386, PMCID: PMC8575900, DOI: 10.1038/s41467-021-26787-7.
- Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporterSingh S, Chaube B, Mayengbam S, Singh A, Malvi P, Mohammad N, Deb A, Bhat M. Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2020, 1867: 166011. PMID: 33212188, DOI: 10.1016/j.bbadis.2020.166011.
- Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune responseSahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. Journal Of Clinical Investigation 2019, 129: 5518-5536. PMID: 31710308, PMCID: PMC6877327, DOI: 10.1172/jci127125.
- Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesisSingh AK, Aryal B, Chaube B, Rotllan N, Varela L, Horvath TL, Suárez Y, Fernández-Hernando C. Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis. Molecular Metabolism 2018, 11: 59-69. PMID: 29627378, PMCID: PMC6001401, DOI: 10.1016/j.molmet.2018.03.011.
- Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesisAryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight 2018, 3: e97918. PMID: 29563332, PMCID: PMC5926923, DOI: 10.1172/jci.insight.97918.
- Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese stateMalvi P, Chaube B, Singh S, Mohammad N, Vijayakumar M, Singh S, Chouhan S, Bhat M. Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state. Cancer & Metabolism 2018, 6: 2. PMID: 29568521, PMCID: PMC5859707, DOI: 10.1186/s40170-018-0176-5.
- Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistanceMalvi P, Chaube B, Singh S, Mohammad N, Pandey V, Vijayakumar M, Radhakrishnan R, Vanuopadath M, Nair S, Nair B, Bhat M. Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance. Cancer & Metabolism 2016, 4: 21. PMID: 27980732, PMCID: PMC5142287, DOI: 10.1186/s40170-016-0162-8.
- AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cellsChaube B, Bhat M. AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells. Cell Death & Disease 2016, 7: e2044-e2044. PMID: 26775698, PMCID: PMC4816182, DOI: 10.1038/cddis.2015.404.
- Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironmentSingh S, Ajay A, Mohammad N, Malvi P, Chaube B, Meena A, Bhat M. Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment. Cell Death & Disease 2015, 6: e1934-e1934. PMID: 26492368, PMCID: PMC4632313, DOI: 10.1038/cddis.2015.292.
- Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progressionChaube B, Malvi P, Singh S, Mohammad N, Meena A, Bhat M. Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. Oncotarget 2015, 6: 37281-37299. PMID: 26484566, PMCID: PMC4741930, DOI: 10.18632/oncotarget.6134.
- Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complexMohammad N, Vikram Singh S, Malvi P, Chaube B, Athavale D, Vanuopadath M, Nair S, Nair B, Bhat M. Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complex. Scientific Reports 2015, 5: 11853. PMID: 26149967, PMCID: PMC4493576, DOI: 10.1038/srep11853.
- High fat diet promotes achievement of peak bone mass in young ratsMalvi P, Piprode V, Chaube B, Pote S, Mittal M, Chattopadhyay N, Wani M, Bhat M. High fat diet promotes achievement of peak bone mass in young rats. Biochemical And Biophysical Research Communications 2014, 455: 133-138. PMID: 25450704, DOI: 10.1016/j.bbrc.2014.10.131.
- Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokinesMalvi P, Chaube B, Pandey V, Vijayakumar M, Boreddy P, Mohammad N, Singh S, Bhat M. Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines. Molecular Oncology 2014, 9: 689-703. PMID: 25499031, PMCID: PMC5528703, DOI: 10.1016/j.molonc.2014.11.006.
- Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanomaMohammad N, Malvi P, Meena A, Singh S, Chaube B, Vannuruswamy G, Kulkarni M, Bhat M. Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanoma. Molecular Cancer 2014, 13: 204. PMID: 25178635, PMCID: PMC4175626, DOI: 10.1186/1476-4598-13-204.
- Hyperglycemia regulates MDR‐1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5‐fluorouracil in MCF‐7 cellsPandey V, Chaube B, Bhat M. Hyperglycemia regulates MDR‐1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5‐fluorouracil in MCF‐7 cells. Journal Of Cellular Biochemistry 2011, 112: 2942-2952. PMID: 21630327, DOI: 10.1002/jcb.23210.