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INFORMATION FOR

Arnar Geirsson

MD, FACS, FAHA
Professor of Surgery (Cardiac); Division Chief, Cardiac Surgery, Surgery

Contact Information

Arnar Geirsson, MD, FACS, FAHA

Mailing Address

  • Cardiac Surgery

    PO Box 208062

    New Haven, CT 06520-8062

    United States

Research Summary

Clinical research projects as part of the Cardiac Surgery Outcome Research Group

1. Volume outcome relationship in cardiac surgery

2. Surgical treatment of endocarditis in drug users

3. Long-term outcomes of patients with severe aortic stenosis - longitudinal data

4. Long-term outcome of patients with severe mitral regurgitation - longitudinal data.

5. Anticoagulation strategies following biological valve replacements.

6. NORCAAD. Nordic Consortium on Acute Type A Aortic Dissection.


Basic science research

1. Pathophysiology of mitral valve prolapse/myxomatous mitral valve disease. Translational research using murine models of mitral valve disease and human mitral valves.


Coauthors

Research Interests

Cardiac Surgical Procedures; Mitral Valve Prolapse; Aortic Aneurysm, Thoracic; Minimally Invasive Surgical Procedures

Research Image

Selected Publications

  • Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled TrialsAhmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. DOI: 10.1016/j.jscai.2022.100383.
  • Expanding Heart Transplants from Donors After Circulatory Death (DCD) - Results of the First Randomized Controlled Trial Using the Organ Care System (OCS™) Heart - (OCS DCD Heart Trial)Schroder J, Shah A, Pretorius V, Smith J, Daneshmand M, Geirsson A, Pham S, Um J, Silvestry S, Shaffer A, Mudy K, Kai M, Joyce D, Philpott J, Takeda K, Goldstein D, Shudo Y, Couper G, Mallidi H, Esmailian F, Pham D, Salerno C, Lozonschi L, Quader M, Patel C, DeVore A, Bryner B, Madsen J, Absi T, Milano C, D'Alessandro D. Expanding Heart Transplants from Donors After Circulatory Death (DCD) - Results of the First Randomized Controlled Trial Using the Organ Care System (OCS™) Heart - (OCS DCD Heart Trial) The Journal Of Heart And Lung Transplantation 2022, 41: s72. DOI: 10.1016/j.healun.2022.01.165.
  • IMPACT OF ATRIAL FIBRILLATION ON SURVIVAL IN PATIENTS WITH DILATED ATRIUM ACROSS DIFFERENT SEVERITIES OF ATRIAL FUNCTIONAL MITRAL REGURGITATIONAmabile A, Mori M, Zogg C, Agarwal R, Krane M, Sugeng L, GEIRSSON A. IMPACT OF ATRIAL FIBRILLATION ON SURVIVAL IN PATIENTS WITH DILATED ATRIUM ACROSS DIFFERENT SEVERITIES OF ATRIAL FUNCTIONAL MITRAL REGURGITATION Journal Of The American College Of Cardiology 2022, 79: 219. DOI: 10.1016/s0735-1097(22)01210-4.
  • Abstract 12518: Susceptibility of Mature Human Myocardial Cell Types to SARS-CoV-2Sotolongo A, Klein J, Pena-Hernandez M, Johnson J, Geirsson A, Pober J, Iwasaki A, Gruber P. Abstract 12518: Susceptibility of Mature Human Myocardial Cell Types to SARS-CoV-2 Circulation 2021, 144: a12518-a12518. DOI: 10.1161/circ.144.suppl_1.12518.
  • Abstract 12292: Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency CandidatesFuery M, Chouairi F, Natov P, Bhinder J, Chiravuri M, Wilson L, Clark K, Reinhardt S, Mullan C, Miller E, Rogers J, Patel C, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Abstract 12292: Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates Circulation 2021, 144: a12292-a12292. DOI: 10.1161/circ.144.suppl_1.12292.
  • CARDIAC STRUCTURAL CHANGES, END-ORGAN MORBIDITIES AND MORTALITY RELATE TO AORTIC STENOSIS IN A DEGREE-REPONSE RELATIONSHIPYousef S, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Geirsson A, Vallabhajosyula P. CARDIAC STRUCTURAL CHANGES, END-ORGAN MORBIDITIES AND MORTALITY RELATE TO AORTIC STENOSIS IN A DEGREE-REPONSE RELATIONSHIP Journal Of The American College Of Cardiology 2021, 77: 1750. DOI: 10.1016/s0735-1097(21)03106-5.
  • ZFYVE21 is a Mediator of Non-Canonical Hedgehog Signaling Activating NLRP3 Inflammasomes in a Pathologic Subset of CD4+PD-1hi T CellsJiang B, Fang C, Soh C, Li X, Geirsson A, Tellides G, Pober J, Jane-Wit D. ZFYVE21 is a Mediator of Non-Canonical Hedgehog Signaling Activating NLRP3 Inflammasomes in a Pathologic Subset of CD4+PD-1hi T Cells The Journal Of Heart And Lung Transplantation 2021, 40: s136. DOI: 10.1016/j.healun.2021.01.422.
  • CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 WITH RESPIRATORY FAILURE REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATIONFouad J, Singh I, Khosla A, Szabo C, Tantawy H, Razo-Vazquez A, Geirsson A, Bonde P, Fajardo E, Joseph P, Siner J, Chichra A. CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 WITH RESPIRATORY FAILURE REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION CHEST Journal 2020, 158: a703-a704. PMCID: PMC7548617, DOI: 10.1016/j.chest.2020.08.660.
  • SUCCESSFUL ROBOTIC MITRAL VALVE REPAIR OF ENDOCARDITIS WITH LEAFLET PERFORATION IN A HIGH RISK PATIENTJeyashanmugaraja G, Stawiarski K, Gomez D, Geirsson A, Zarich S. SUCCESSFUL ROBOTIC MITRAL VALVE REPAIR OF ENDOCARDITIS WITH LEAFLET PERFORATION IN A HIGH RISK PATIENT CHEST Journal 2020, 158: a163. DOI: 10.1016/j.chest.2020.08.177.
  • TCT CONNECT-107 Poor Survival in Patients With Aortic Stenosis Without InterventionYousef S, Same H, Mori M, Agarwal R, Singh S, Brooks C, Mena-Hurtado C, Smolderen K, Nagpal S, Cleman M, Forrest J, Kaple R, Zhang Y, Assi R, Geirsson A. TCT CONNECT-107 Poor Survival in Patients With Aortic Stenosis Without Intervention Journal Of The American College Of Cardiology 2020, 76: b47-b48. DOI: 10.1016/j.jacc.2020.09.121.
  • TCT CONNECT-4 Surgical EXPLANTation After Transcatheter Aortic Valve Replacement Failure: Midterm Outcomes From the EXPLANT-TAVR International RegistryTang G, Sengupta A, Zaid S, Vitanova K, Lange R, Munsterer A, Simon S, Fukuhara S, Deeb G, Oakley J, Voisine P, Mohammadi S, Kalavrouziotis D, Doyle D, Rodés-Cabau J, Dumont E, Alperi A, von Ballmoos M, Reardon M, Atkins M, Kleiman N, Chu M, Bagur R, Algadheeb M, Desai N, Bavaria J, Walsh E, Conradi L, Bhadra O, Schults C, Satler L, Waksman R, Ramlawi B, Andreas M, Werner P, Modine T, Leroux L, Whisenant B, Doty J, Robinson N, Wang L, Petrossian G, Goldberg J, Spielvogel D, Ahmad H, Bruschi G, Goel K, Shah A, Geirsson A, Forrest J, Grubb K, Hirji S, Shah P, Gelpi G, Ouzounian M, Ruel M, Al-Atassi T, Kempfert J, Unbehaun A, Sonnabend S, Ali W, Demers P, Ibrahim R, Garatti A, Nguyen T, Pizano A, Di Eusanio M, Capestro F, Estevez-Loureiro R, Salinger M, Rovin J, Fisher S, D'Onofrio A, Divirgilio A, Maisano F, Taramasso M, Gennari M, Colli A, Denti P, Kaneko T, Bapat V. TCT CONNECT-4 Surgical EXPLANTation After Transcatheter Aortic Valve Replacement Failure: Midterm Outcomes From the EXPLANT-TAVR International Registry Journal Of The American College Of Cardiology 2020, 76: b2-b3. DOI: 10.1016/j.jacc.2020.09.019.
  • TCT CONNECT-112 Intervention Management Strategies and Association With Long-Term Mortality in Patients With Concomitant Aortic Valve Stenosis and Coronary Artery DiseaseYousef S, Mori M, Assi R, Smolderen K, Kaple R, Forrest J, Cleman M, Mena-Hurtado C, Geirsson A, Vallabhajosyula P. TCT CONNECT-112 Intervention Management Strategies and Association With Long-Term Mortality in Patients With Concomitant Aortic Valve Stenosis and Coronary Artery Disease Journal Of The American College Of Cardiology 2020, 76: b50. DOI: 10.1016/j.jacc.2020.09.126.
  • Abstract 215: Cardiac Surgeons' Treatment Preferences for Infective Endocarditis Based on Patients' Drug Use StatusNguemeni Tiako M, Mori M, Bin Mahmood S, Mszar R, Brooks C, Bonde P, Tellides G, Weimer M, Geirsson A. Abstract 215: Cardiac Surgeons' Treatment Preferences for Infective Endocarditis Based on Patients' Drug Use Status Circulation Cardiovascular Quality And Outcomes 2020, 13 DOI: 10.1161/hcq.13.suppl_1.215.
  • Outcomes of Left Ventricular Assist Device Implantation with Mitral Regurgitation with and without Concomitant Mitral OperationVinholo T, Mullan C, Mori M, Caraballo C, Ravindra N, Miller E, McCullough M, Clarke J, Geirsson A, Desai N, Ahmad T. Outcomes of Left Ventricular Assist Device Implantation with Mitral Regurgitation with and without Concomitant Mitral Operation The Journal Of Heart And Lung Transplantation 2020, 39: s441-s442. DOI: 10.1016/j.healun.2020.01.251.
  • Clinical Implications of Concomitant Surgical Intervention for Aortic Insufficiency with Left Ventricular Assist Device ImplantationMullan C, Mori M, Caraballo C, Ravindra N, Miller E, McCullough M, Clarke J, Geirsson A, Desai N, Ahmad T. Clinical Implications of Concomitant Surgical Intervention for Aortic Insufficiency with Left Ventricular Assist Device Implantation The Journal Of Heart And Lung Transplantation 2020, 39: s440. DOI: 10.1016/j.healun.2020.01.248.
  • Blood Conservation Strategy at Time of Left Ventricular Assist Device Placement Improves SurvivalStawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Lee F, Jacoby D, Bellumkonda L, Ahmad T, Chou J, Testani J, Chen M, McCloskey G, Bonde P. Blood Conservation Strategy at Time of Left Ventricular Assist Device Placement Improves Survival The Journal Of Heart And Lung Transplantation 2020, 39: s151. DOI: 10.1016/j.healun.2020.01.1086.
  • Questionable Value of Concomitant Tricuspid Valve Procedure with Left Ventricular Assist Device ImplantationMullan C, Mori M, Caraballo C, Ravindra N, Miller E, McCullough M, Clarke J, Geirsson A, Desai N, Ahmad T. Questionable Value of Concomitant Tricuspid Valve Procedure with Left Ventricular Assist Device Implantation The Journal Of Heart And Lung Transplantation 2020, 39: s118. DOI: 10.1016/j.healun.2020.01.997.
  • The Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative PeriodStawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Bellumkonda L, Lee F, Chen M, Jacoby D, Chou J, Ahmad T, Testani J, McCloskey G, Bonde P. The Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period The Journal Of Heart And Lung Transplantation 2020, 39: s151-s152. DOI: 10.1016/j.healun.2020.01.1087.
  • REAL-WORLD VERSUS CLINICAL TRIAL OUTCOMES FROM LVADSMezzacappa C, Ravindra N, Carabello C, Chouairi F, McCullough M, Miller P, Clarke J, Gruen J, Mullan C, Geirsson A, Rogers J, Desai N, Ahmad T. REAL-WORLD VERSUS CLINICAL TRIAL OUTCOMES FROM LVADS Journal Of The American College Of Cardiology 2020, 75: 771. DOI: 10.1016/s0735-1097(20)31398-x.
  • CLINICAL IMPACT OF PSYCHIATRIC COMORBIDITIES ON OUTCOMES AFTER LEFT VENTRICULAR ASSIST DEVICE IMPLANTATIONMullan C, Mori M, Caraballo C, Ravindra N, Miller P, McCullough M, Clarke J, Geirsson A, Desai N, Ahmad T. CLINICAL IMPACT OF PSYCHIATRIC COMORBIDITIES ON OUTCOMES AFTER LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION Journal Of The American College Of Cardiology 2020, 75: 967. DOI: 10.1016/s0735-1097(20)31594-1.
  • P206 Immediate impact of coronary revascularization on global and regional myocardial function evaluated by speckle tracking echocardiographyChen W, Zhu Q, Posada-Martinez E, Ortiz-Leon X, Pereira J, Dewar M, Darr U, Geirsson A, Sugeng L. P206 Immediate impact of coronary revascularization on global and regional myocardial function evaluated by speckle tracking echocardiography European Heart Journal - Cardiovascular Imaging 2020, 21 DOI: 10.1093/ehjci/jez319.074.
  • TCT-763 Valve in Valve Transcatheter Aortic Valve Replacement Versus Redo Surgical Aortic Valve Replacement: Real World Outcomes From the National Inpatient Sample (2013–2016)Kim G, Geirsson A, Cleman M, Forrest J, Kaple R. TCT-763 Valve in Valve Transcatheter Aortic Valve Replacement Versus Redo Surgical Aortic Valve Replacement: Real World Outcomes From the National Inpatient Sample (2013–2016) Journal Of The American College Of Cardiology 2019, 74: b748. DOI: 10.1016/j.jacc.2019.08.902.
  • TCT-237 Revascularization Options for Women With Coronary Artery Disease: A Meta-Analysis of Randomized Controlled TrialsShah T, Gul B, Head S, Abbott J, Chieffo A, Baumbach A, Hu X, Li F, Brackett A, Gesick C, Bisarya P, Mehran R, Grines C, Geirsson A, Mehilli J, Lansky A. TCT-237 Revascularization Options for Women With Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials Journal Of The American College Of Cardiology 2019, 74: b236. DOI: 10.1016/j.jacc.2019.08.303.
  • Abstract 255: Patterns of Addiction Treatment for Patients Undergoing Cardiac Surgery for Infective Endocarditis Associated with Intravenous Drug UseNguemeni Tiako M, Hong S, Bin Mahmood S, Darr U, Mangi A, Jutthani-Mehta M, Geirsson A. Abstract 255: Patterns of Addiction Treatment for Patients Undergoing Cardiac Surgery for Infective Endocarditis Associated with Intravenous Drug Use Circulation Cardiovascular Quality And Outcomes 2019, 12 DOI: 10.1161/hcq.12.suppl_1.255.
  • LVAD Survival May Be Predicted by Preoperative LymphopeniaStawiarski K, Agboola O, Jacoby D, Bellumkonda L, Sugeng L, Ahmad T, Chen M, McCloskey G, Geirsson A, Anwar M, Bonde P. LVAD Survival May Be Predicted by Preoperative Lymphopenia The Journal Of Heart And Lung Transplantation 2019, 38: s63-s64. DOI: 10.1016/j.healun.2019.01.142.
  • Chloride Homeostasis in End Stage Heart Failure and LVAD RecipientsStawiarski K, Agboola O, Jacoby D, Bellumkonda L, Ahmad T, Sugeng L, Chen M, McCloskey G, Geirsson A, Anwar M, Bonde P. Chloride Homeostasis in End Stage Heart Failure and LVAD Recipients The Journal Of Heart And Lung Transplantation 2019, 38: s382-s383. DOI: 10.1016/j.healun.2019.01.974.
  • IDENTIFICATION OF RISK FACTORS AND DEVELOPMENT AND VALIDATION OF A PREDICTION MODEL TO DETECT ASCENDING THORACIC AORTIC ANEURYSMMori M, Yousef S, Bin Mahmood S, Mangi A, Geirsson A. IDENTIFICATION OF RISK FACTORS AND DEVELOPMENT AND VALIDATION OF A PREDICTION MODEL TO DETECT ASCENDING THORACIC AORTIC ANEURYSM Journal Of The American College Of Cardiology 2019, 73: 1558. DOI: 10.1016/s0735-1097(19)32164-3.
  • TRENDS IN INFECTIVE ENDOCARDITIS INCIDENCE, CHARACTERISTICS, AND VALVE REPLACEMENT IN PATIENTS WITH OPIOID USE DISORDERS IN THE UNITED STATES FROM 2005 TO 2014Mori M, Brown K, Bin Mahmood S, Geirsson A, Mangi A. TRENDS IN INFECTIVE ENDOCARDITIS INCIDENCE, CHARACTERISTICS, AND VALVE REPLACEMENT IN PATIENTS WITH OPIOID USE DISORDERS IN THE UNITED STATES FROM 2005 TO 2014 Journal Of The American College Of Cardiology 2019, 73: 1968. DOI: 10.1016/s0735-1097(19)32574-4.
  • LYMPHOPENIA AS A PREDICTOR FOR SURVIVAL IN LVAD PATIENTSStawiarski K, Agboola O, Jacoby D, Ali A, Bellumkonda L, Ahmad T, Sugeng L, McCloskey G, Chen M, Geirsson A, Bonde P, Anwer M. LYMPHOPENIA AS A PREDICTOR FOR SURVIVAL IN LVAD PATIENTS Journal Of The American College Of Cardiology 2019, 73: 802. DOI: 10.1016/s0735-1097(19)31409-3.
  • Árangur kransæðahjáveituaðgerða hjá konum á ÍslandiGarðarsdóttir H, Árnadóttir L, Aðalsteinsson J, Jóhannesdóttir H, Helgadóttir S, Hrafnkelsdóttir Þ, Geirsson A, Guðbjartsson T. Árangur kransæðahjáveituaðgerða hjá konum á Íslandi Læknablaðið 2018, 2018: 335-340. DOI: 10.17992/lbl.2018.0708.192.
  • Abstract 17817: The Incidence and Mortality Risk of Acute Thoracic Aortic Dissection: Results From a Nationwide Population-based StudyMelvinsdottir I, Lund S, Agnarsson B, Sigvaldason K, Gudbjartsson T, Geirsson A. Abstract 17817: The Incidence and Mortality Risk of Acute Thoracic Aortic Dissection: Results From a Nationwide Population-based Study Circulation 2015, 132 DOI: 10.1161/circ.132.suppl_3.17817.
  • Surgical Treatment of Thoracic Aortic Disease in the ElderlyGeirsson A. Surgical Treatment of Thoracic Aortic Disease in the Elderly 2011, 427-436. DOI: 10.1007/978-1-4419-0892-6_33.
  • 446: Dynamic Regulation of Micro RNAs in Ischemic Cardiac Remodeling and Heart FailureAli R, Kim R, Tellides G, Geirsson A. 446: Dynamic Regulation of Micro RNAs in Ischemic Cardiac Remodeling and Heart Failure The Journal Of Heart And Lung Transplantation 2009, 28: s220-s221. DOI: 10.1016/j.healun.2008.11.453.
  • Abstract 3056: Ischemia on Presentation Stratifies Mortality Risk in Surgery for Acute Type A DissectionAugoustides J, Geirsson A, Szeto W, Walsh L, Cornelius B, Pochettino A, Bavaria J. Abstract 3056: Ischemia on Presentation Stratifies Mortality Risk in Surgery for Acute Type A Dissection Circulation 2007, 116 DOI: 10.1161/circ.116.suppl_16.ii_684-d.
  • Inhibition of T-lymphocyte stimulation by a trophoblast non-coding RNA suppressing MHC class II expression in murine B-cellsGeirsson A, Bothwell A, Hammond G, Hammond G. Inhibition of T-lymphocyte stimulation by a trophoblast non-coding RNA suppressing MHC class II expression in murine B-cells The Journal Of Heart And Lung Transplantation 2004, 23: s48. DOI: 10.1016/j.healun.2003.11.020.

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