Antoni Duleba, MD
Research & Publications
Ovarian function remains under control of a broad range of endocrine and paracrine agents. It is apparent that insulin and insulin growth factors play significant roles in the control of ovarian folliculogenesis and steroid genesis. Excessive levels of insulin and/or IGF-1 may be involved in the pathogenesis of a common endocrine disorder: Polycystic Ovary Syndrome (PCOS). Our recent data indicate that PCOS is associated with increased oxidative stress, systemic inflammation and dyslipidemia. These clinical observations are paralleled by our in vitro studies, whereby we observed that oxidative stress can mimic actions of insulin and IGF-1 and promote proliferation of cultured stromal and thecal cells, as well as increased production of androgens. Our current efforts are focused on determining the effects of oxidative stress, antioxidants, and their interactions with insulin and growth factors on the function of ovarian cells in culture and in clinical settings. Furthermore, we are investigating the effects of statins on ovarian function in vitro and in vivo. We have demonstrated that statins inhibit proliferation and steroidogenesis of theca-interstitial cells. In patients with PCOS, use of statin results in decreased levels of testosterone and improvement of LH to FSH ratio.
Insulin; Obstetrics; Polycystic Ovary Syndrome; Oxidative Stress; Dyslipidemias
- Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesisIzquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ. Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis Fertility And Sterility 2004, 82: 1193-1197. PMID: 15474095, DOI: 10.1016/j.fertnstert.2004.03.037.
- Effects of oxidants and antioxidants on proliferation of endometrial stromal cellsFoyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells Fertility And Sterility 2004, 82: 1019-1022. PMID: 15474067, DOI: 10.1016/j.fertnstert.2004.02.133.
- Proliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stressDuleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman HR. Proliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress Human Reproduction 2004, 19: 1519-1524. PMID: 15178657, DOI: 10.1093/humrep/deh299.
- Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndromePawelczyk L, Spaczynski RZ, Banaszewska B, Duleba AJ. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome European Journal Of Obstetrics & Gynecology And Reproductive Biology 2004, 113: 209-213. PMID: 15063962, DOI: 10.1016/j.ejogrb.2003.09.031.