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Ania Jastreboff, MD, PhD

Associate Professor; Director, Weight Management & Obesity Prevention; Medical Director, Yale Stress Center

Contact Information

Ania Jastreboff, MD, PhD

Mailing Address

  • Endocrinology

    2 Church Street South

    New Haven, CT, 06519

    United States

Research Summary

Dr. Jastreboff’s obesity research program seeks to better understand: 1) the neurobiology of obesity, 2) neural mechanisms underlying anti-obesity pharmacotherapy, 3) and clinical outcomes of anti-obesity pharmacotherapy.

During her doctoral thesis work, Dr. Jastreboff became interested in understanding how metabolic perturbations, such as insulin resistance, hyperinsulinemia, leptin resistance, etc, affect neural mechanisms, which subsequently impact eating behavior and weight gain. To this end, she utilizes functional MRI to examine neural responses in obese adults and adolescents (insulin resistant and insulin sensitive) to various food cues (viewing images of high-calorie and low-calorie foods, ingestion of glucose or fructose drinks, etc). She then expanded her work to include investigation of hoe treatment with anti-obesity medications may impact both neural responses as well as eating behavior. Dr. Jastreboff’s overarching goal is to conduct research that is clinically applicable for the treatment of obesity and has a clear public health impact to mitigate the obesity pandemic.

Specialized Terms: Obesity; Obesity Medicine; Anti-obesity pharmacotherapy; Insulin resistance; Type 2 diabetes; Neural control of eating behaviors; Weight-loss maintenance; Dietary glycemic index, Diabetes technology tools, Transitions of care from pediatric to adult care

Extensive Research Description

obesity and cancer; anti-obesity pharmacotherapy; cancer prevention and risk reduction

Coauthors

Research Interests

Obesity; Weight Loss

Public Health Interests

Obesity

Selected Publications

Clinical Trials

ConditionsStudy Title
Mental Health & Behavioral Research; Obesity & Weight ControlGLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight
Obesity & Weight ControlA Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight (SURMOUNT-1)
Diseases of the Cardiovascular System; Obesity & Weight ControlSemaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT)
Mental Health & Behavioral Research; Tobacco AddictionImaging Tobacco Smoking Withdrawal using [11C]PHNO
Obesity & Weight ControlEffect of liraglutide on neural responses to high fructose corn syrup in individuals with obesity
Addictive Behaviors; Mental Health & Behavioral Research; Obesity & Weight ControlBehavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment
Diabetes Mellitus - Type 1; Diabetes Mellitus - Type 2; Diseases of the Endocrine SystemRestoring brain metabolism and function in older adult T1DM patients using an AP system
Diabetes Mellitus - Type 1; Diseases of the Endocrine System; Diseases of the Nervous SystemImpact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM
Addictive Behaviors; Obesity & Weight ControlBehavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco AddictionEffects of Brief Training on Craving Regulation
Children's Health; Diabetes Mellitus - Type 2; Diseases of the Cardiovascular System; Diseases of the Endocrine System; Genetics - Pediatric; Obesity & Weight ControlPrevalence of Carbohydrate Intolerance in Lean and Obese Children