Ania Jastreboff, MD, PhD
Associate Professor; Director, Weight Management & Obesity Prevention; Medical Director, Yale Stress Center
Research & Publications
Biography
News
Research Summary
Dr. Jastreboff’s obesity research program seeks to better understand: 1) the neurobiology of obesity, 2) neural mechanisms underlying anti-obesity pharmacotherapy, 3) and clinical outcomes of anti-obesity pharmacotherapy.
During her doctoral thesis work, Dr. Jastreboff became interested in understanding how metabolic perturbations, such as insulin resistance, hyperinsulinemia, leptin resistance, etc, affect neural mechanisms, which subsequently impact eating behavior and weight gain. To this end, she utilizes functional MRI to examine neural responses in obese adults and adolescents (insulin resistant and insulin sensitive) to various food cues (viewing images of high-calorie and low-calorie foods, ingestion of glucose or fructose drinks, etc). She then expanded her work to include investigation of hoe treatment with anti-obesity medications may impact both neural responses as well as eating behavior. Dr. Jastreboff’s overarching goal is to conduct research that is clinically applicable for the treatment of obesity and has a clear public health impact to mitigate the obesity pandemic.
Specialized Terms: Obesity; Obesity Medicine; Anti-obesity pharmacotherapy; Insulin resistance; Type 2 diabetes; Neural control of eating behaviors; Weight-loss maintenance; Dietary glycemic index, Diabetes technology tools, Transitions of care from pediatric to adult care
Extensive Research Description
obesity and cancer; anti-obesity pharmacotherapy; cancer prevention and risk reduction
Coauthors
Research Interests
Obesity; Weight Loss
Public Health Interests
Obesity
Selected Publications
- Obesity as a Disease: The Obesity Society 2018 Position Statement.Jastreboff AM, Kotz CM, Kahan S, Kelly AS, Heymsfield SB. Obesity as a Disease: The Obesity Society 2018 Position Statement. Obesity (Silver Spring, Md.) 2019, 27:7-9.
- Treatment of Adolescent Obesity in 2020.Cardel MI, Jastreboff AM, Kelly AS. Treatment of Adolescent Obesity in 2020. JAMA 2019.
- AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY.Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY. Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists 2016, 22 Suppl 3:1-203.
- COMMENTARY FROM THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS ON THE U.S. PREVENTIVE SERVICES TASK FORCE RECOMMANDATIONS REGARDING WEIGHT LOSS INTERVENTIONS.Garvey WT, Jastreboff AM. COMMENTARY FROM THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS ON THE U.S. PREVENTIVE SERVICES TASK FORCE RECOMMANDATIONS REGARDING WEIGHT LOSS INTERVENTIONS. Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists 2019, 25:394-395.
- Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity.Srivastava G, Fox CK, Kelly AS, Jastreboff AM, Browne AF, Browne NT, Pratt JSA, Bolling C, Michalsky MP, Cook S, Lenders CM, Apovian CM. Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity. Obesity (Silver Spring, Md.) 2019, 27:190-204.
- Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents.Jastreboff AM, Sinha R, Arora J, Giannini C, Kubat J, Malik S, Van Name MA, Santoro N, Savoye M, Duran EJ, Pierpont B, Cline G, Constable RT, Sherwin RS, Caprio S. Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes 2016, 65:1929-39.
- Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels.Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels. Diabetes Care 2013, 36:394-402.
- Leptin is associated with exaggerated brain reward and emotion responses to food images in adolescent obesity.Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. Leptin is associated with exaggerated brain reward and emotion responses to food images in adolescent obesity. Diabetes Care 2014, 37:3061-8.
- Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance.Van Name M, Giannini C, Santoro N, Jastreboff AM, Kubat J, Li F, Kursawe R, Savoye M, Duran E, Dziura J, Sinha R, Sherwin RS, Cline G, Caprio S. Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance. Obesity (Silver Spring, Md.) 2015, 23:653-61.
- Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: an FMRI study.Jastreboff AM, Potenza MN, Lacadie C, Hong KA, Sherwin RS, Sinha R. Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: an FMRI study. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2011, 36:627-37.
- Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO.Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2016, 41:3042-3050.
- Paying our sleep debt in extra poundsJastreboff AM. Paying our sleep debt in extra pounds. Science Translational Medicine.5:178. March 2013. DOI: 10.1126/scitranslmed.3006149
- BAT Burns Fat? CoolJastreboff AM. BAT Burns Fat? Cool. Science Translational Medicine. Vol. 5, Issue 202, p. 202ec148. September 2013. DOI: 10.1126/scitranslmed.3007485
- Linking an Obesity-Associated Gene Variant, Ghrelin, and the BrainJastreboff AM. Linking an Obesity-Associated Gene Variant, Ghrelin, and the Brain. Science Translational Medicine. 2013 July 31; Vol 5, Issue 196, p. 184ec124. DOI: 10.1126/scitranslmed.3007044
- Oxytocin Curbs Cookie ConsumptionJastreboff AM. Oxytocin Curbs Cookie Consumption. Science Translational Medicine. Vol. 5, Issue 208, p. 208ec173. October 2013. DOI: 10.1126/scitranslamed.3007768
- Insulin: Food for ThoughtJastreboff AM. Insulin: Food for Thought. Science Translational Medicine. Vol. 6, Issue 226, p. 226ec39. March 2014. DOI: 10.1126/scitranslmed.3008712
- Demystifying the “magical cure” for diabetesJastreboff AM. Demystifying the “magical cure” for diabetes. Science Translational Medicine. Vol. 5, Issue 184, p. 184ec76. May 2013. DOI: 10.1126/scitranslmed.3006449
- Phentermine/Topiramate and Lifestyle Modification Effective for Weight Loss in DiabeticsJastreboff AM. Phentermine/Topiramate and Lifestyle Modification Effective for Weight Loss in Diabetics. Editorial. PracticeUpdate website. Available at: http://www.practiceupdate.com/journalscan/14806. Accessed December 22, 2014.
- Bariatric Surgery-Induced Weight Loss Causes Remission of Food Addiction in Extreme ObesityJastreboff AM. Bariatric Surgery-Induced Weight Loss Causes Remission of Food Addiction in Extreme Obesity. Editorial. PracticeUpdate website. Available at: http://www.practiceupdate.com/journalscan/11791. Accessed August 19, 2014.
- Hooked on Sugar? Effect of Sucrose on Stress-Induced Cortisol ReleaseJastreboff AM. Hooked on Sugar? Effect of Sucrose on Stress-Induced Cortisol Release. PracticeUpdate website. Available at: http://www.practiceupdate.com/c/24494/48/8. Accessed May 18, 2015.
- Diabetes Shrinks the BrainJastreboff AM. Diabetes Shrinks the Brain. Science Translational Medicine. Vol. 5, Issue 214, p.214ec199. December 2013. DOI: 10.1126/scitranslmed.3008073
- Sex differences in the association between dietary restraint, insulin resistance and obesity.Jastreboff AM, Gaiser EC, Gu P, Sinha R. Sex differences in the association between dietary restraint, insulin resistance and obesity. Eating Behaviors 2014, 15:286-90.
- Stress as a common risk factor for obesity and addiction.Sinha R, Jastreboff AM. Stress as a common risk factor for obesity and addiction. Biological Psychiatry 2013, 73:827-35.
- Year in diabetes 2012: The diabetes tsunami.Sherwin R, Jastreboff AM. Year in diabetes 2012: The diabetes tsunami. The Journal Of Clinical Endocrinology And Metabolism 2012, 97:4293-301.
- Comparison of BMI and physical activity between old order Amish children and non-Amish children.Hairston KG, Ducharme JL, Treuth MS, Hsueh WC, Jastreboff AM, Ryan KA, Shi X, Mitchell BD, Shuldiner AR, Snitker S. Comparison of BMI and physical activity between old order Amish children and non-Amish children. Diabetes Care 2013, 36:873-8.
- Blunted striatal responses to favorite-food cues in smokers.Jastreboff AM, Sinha R, Lacadie CM, Balodis IM, Sherwin R, Potenza MN. Blunted striatal responses to favorite-food cues in smokers. Drug And Alcohol Dependence 2015, 146:103-6.
- Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers.Garrison KA, Sinha R, Lacadie CM, Scheinost D, Jastreboff AM, Constable RT, Potenza MN. Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2016, 18:1820-9.
- Stress, cortisol, and other appetite-related hormones: Prospective prediction of 6-month changes in food cravings and weight.Chao AM, Jastreboff AM, White MA, Grilo CM, Sinha R. Stress, cortisol, and other appetite-related hormones: Prospective prediction of 6-month changes in food cravings and weight. Obesity (Silver Spring, Md.) 2017, 25:713-720.
- The brains behind alcohol relapseJastreboff AM. The brains behind alcohol relapse. Science Translational Medicine. Vol. 5, Issue 185, p. 185ec82. May 2013. DOI: 10.1126/scitranslmed.300652
- Preventing Childhood Obesity Through a Mindfulness-Based Parent Stress Intervention: A Randomized Pilot Study.Jastreboff AM, Chaplin TM, Finnie S, Savoye M, Stults-Kolehmainen M, Silverman WK, Sinha R. Preventing Childhood Obesity Through a Mindfulness-Based Parent Stress Intervention: A Randomized Pilot Study. The Journal Of Pediatrics 2018, 202:136-142.e1.
- Disordered Eating Behaviors in Emerging Adults With Type 1 Diabetes: A Common Problem for Both Men and Women.Doyle EA, Quinn SM, Ambrosino JM, Weyman K, Tamborlane WV, Jastreboff AM. Disordered Eating Behaviors in Emerging Adults With Type 1 Diabetes: A Common Problem for Both Men and Women. Journal Of Pediatric Health Care : Official Publication Of National Association Of Pediatric Nurse Associates & Practitioners 2017, 31:327-333.
- UTILITY OF PSYCHOLOGICAL SCREENING OF YOUNG ADULTS WITH TYPE 1 DIABETES TRANSITIONING TO ADULT PROVIDERS.Quinn SM, Ambrosino JM, Doyle EA, Weyman K, Tamborlane WV, Jastreboff AM. UTILITY OF PSYCHOLOGICAL SCREENING OF YOUNG ADULTS WITH TYPE 1 DIABETES TRANSITIONING TO ADULT PROVIDERS. Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists 2016, 22:1104-10.
- The diagnosis and management of cerebrovascular disease in diabetes.Phipps MS, Jastreboff AM, Furie K, Kernan WN. The diagnosis and management of cerebrovascular disease in diabetes. Current Diabetes Reports 2012, 12:314-23.
- AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITYEXECUTIVE SUMMARYComplete Guidelines available at https://www.aace.com/publications/guidelines.Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITYEXECUTIVE SUMMARYComplete Guidelines available at https://www.aace.com/publications/guidelines. Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists 2016, 22:842-84.
- Three faces of hypothalamic tumors.Jastreboff A, Sherr J. Three faces of hypothalamic tumors. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2007, 20:471.
- Role of the human papilloma virus in the development of cervical intraepithelial neoplasia and malignancy.Jastreboff AM, Cymet T. Role of the human papilloma virus in the development of cervical intraepithelial neoplasia and malignancy. Postgraduate Medical Journal 2002, 78:225-8.
- Mindfulness Based Stress Reduction for Older Couples with Metabolic Syndrome: A Pilot Randomized Controlled TrialMonin JK, Sperduto M, Manigault A, Dutton A, Van Ness P, Ali A, Clark M, Jastreboff AM. Mindfulness Based Stress Reduction for Older Couples with Metabolic Syndrome: A Pilot Randomized Controlled Trial. Mindfulness. Jan 15, 2020.
- Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: A Positron Emission Tomography StudyBini J , Bhatt S, Hillmer A, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin R, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Journal Molecular Imaging and Biology. Accepted for publication February 20, 2020
- Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study.Bini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study. Molecular Imaging And Biology : MIB : The Official Publication Of The Academy Of Molecular Imaging 2020, 22:1124-1131.
- Mindfulnes-Based Stress Reduction for Older Couples with Metabolic Syndrome: a Pilot Randomized Controlled Trial.Monin JK, Sperduto CM, Manigault AW, Dutton A, Ali A, Clark MS, Jastreboff AM. Mindfulnes-Based Stress Reduction for Older Couples with Metabolic Syndrome: a Pilot Randomized Controlled Trial. Mindfulness 2020, 11:917-927.