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Ania Jastreboff, MD, PhD

Associate Professor; Director, Weight Management & Obesity Prevention; Medical Director, Yale Stress Center

Research Summary

Dr. Jastreboff’s obesity research program seeks to better understand: 1) the neurobiology of obesity, 2) neural mechanisms underlying anti-obesity pharmacotherapy, 3) and clinical outcomes of anti-obesity pharmacotherapy.

During her doctoral thesis work, Dr. Jastreboff became interested in understanding how metabolic perturbations, such as insulin resistance, hyperinsulinemia, leptin resistance, etc, affect neural mechanisms, which subsequently impact eating behavior and weight gain. To this end, she utilizes functional MRI to examine neural responses in obese adults and adolescents (insulin resistant and insulin sensitive) to various food cues (viewing images of high-calorie and low-calorie foods, ingestion of glucose or fructose drinks, etc). She then expanded her work to include investigation of hoe treatment with anti-obesity medications may impact both neural responses as well as eating behavior. Dr. Jastreboff’s overarching goal is to conduct research that is clinically applicable for the treatment of obesity and has a clear public health impact to mitigate the obesity pandemic.

Specialized Terms: Obesity; Obesity Medicine; Anti-obesity pharmacotherapy; Insulin resistance; Type 2 diabetes; Neural control of eating behaviors; Weight-loss maintenance; Dietary glycemic index, Diabetes technology tools, Transitions of care from pediatric to adult care

Extensive Research Description

obesity and cancer; anti-obesity pharmacotherapy; cancer prevention and risk reduction

Coauthors

Research Interests

Obesity; Weight Loss

Public Health Interests

Obesity

Selected Publications

  • Paying our sleep debt in extra poundsJastreboff AM. Paying our sleep debt in extra pounds. Science Translational Medicine.5:178. March 2013. DOI: 10.1126/scitranslmed.3006149
  • BAT Burns Fat? CoolJastreboff AM. BAT Burns Fat? Cool. Science Translational Medicine. Vol. 5, Issue 202, p. 202ec148. September 2013. DOI: 10.1126/scitranslmed.3007485
  • Linking an Obesity-Associated Gene Variant, Ghrelin, and the BrainJastreboff AM. Linking an Obesity-Associated Gene Variant, Ghrelin, and the Brain. Science Translational Medicine. 2013 July 31; Vol 5, Issue 196, p. 184ec124. DOI: 10.1126/scitranslmed.3007044
  • Oxytocin Curbs Cookie ConsumptionJastreboff AM. Oxytocin Curbs Cookie Consumption. Science Translational Medicine. Vol. 5, Issue 208, p. 208ec173. October 2013. DOI: 10.1126/scitranslamed.3007768
  • Insulin: Food for ThoughtJastreboff AM. Insulin: Food for Thought. Science Translational Medicine. Vol. 6, Issue 226, p. 226ec39. March 2014. DOI: 10.1126/scitranslmed.3008712
  • Demystifying the “magical cure” for diabetesJastreboff AM. Demystifying the “magical cure” for diabetes. Science Translational Medicine. Vol. 5, Issue 184, p. 184ec76. May 2013. DOI: 10.1126/scitranslmed.3006449
  • Phentermine/Topiramate and Lifestyle Modification Effective for Weight Loss in DiabeticsJastreboff AM. Phentermine/Topiramate and Lifestyle Modification Effective for Weight Loss in Diabetics. Editorial. PracticeUpdate website. Available at: http://www.practiceupdate.com/journalscan/14806. Accessed December 22, 2014.
  • Bariatric Surgery-Induced Weight Loss Causes Remission of Food Addiction in Extreme ObesityJastreboff AM. Bariatric Surgery-Induced Weight Loss Causes Remission of Food Addiction in Extreme Obesity. Editorial. PracticeUpdate website. Available at: http://www.practiceupdate.com/journalscan/11791. Accessed August 19, 2014.
  • Hooked on Sugar? Effect of Sucrose on Stress-Induced Cortisol ReleaseJastreboff AM. Hooked on Sugar? Effect of Sucrose on Stress-Induced Cortisol Release. PracticeUpdate website. Available at: http://www.practiceupdate.com/c/24494/48/8. Accessed May 18, 2015.
  • Diabetes Shrinks the BrainJastreboff AM. Diabetes Shrinks the Brain. Science Translational Medicine. Vol. 5, Issue 214, p.214ec199. December 2013. DOI: 10.1126/scitranslmed.3008073
  • The brains behind alcohol relapseJastreboff AM. The brains behind alcohol relapse. Science Translational Medicine. Vol. 5, Issue 185, p. 185ec82. May 2013. DOI: 10.1126/scitranslmed.300652
  • Mindfulness Based Stress Reduction for Older Couples with Metabolic Syndrome: A Pilot Randomized Controlled TrialMonin JK, Sperduto M, Manigault A, Dutton A, Van Ness P, Ali A, Clark M, Jastreboff AM. Mindfulness Based Stress Reduction for Older Couples with Metabolic Syndrome: A Pilot Randomized Controlled Trial. Mindfulness. Jan 15, 2020.
  • Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: A Positron Emission Tomography StudyBini J , Bhatt S, Hillmer A, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin R, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Journal Molecular Imaging and Biology. Accepted for publication February 20, 2020

Clinical Trials

ConditionsStudy Title
Diabetes Mellitus - Type 2; Obesity & Weight ControlSURMOUNT-2
Diseases of the Digestive System - Stomach; Obesity & Weight ControlTreatments to Treat Loss-of-Control Eating and Improve Weight Outcomes after Bariatric Surgery
Mental Health & Behavioral Research; Obesity & Weight ControlGLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight
Addictive Behaviors; Mental Health & Behavioral Research; Obesity & Weight ControlCognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment
Mental Health & Behavioral Research; Tobacco AddictionImaging Tobacco Smoking Withdrawal using [11C]PHNO
Obesity & Weight ControlEffect of liraglutide on neural responses to high fructose corn syrup in individuals with obesity
Addictive Behaviors; Mental Health & Behavioral Research; Obesity & Weight ControlBehavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment
Diabetes Mellitus - Type 1; Diabetes Mellitus - Type 2; Diseases of the Endocrine SystemRestoring brain metabolism and function in older adult T1DM patients using an AP system
Diabetes Mellitus - Type 1; Diseases of the Endocrine System; Diseases of the Nervous SystemImpact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM
Addictive Behaviors; Obesity & Weight ControlBehavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco AddictionEffects of Brief Training on Craving Regulation
Children's Health; Diabetes Mellitus - Type 2; Diseases of the Cardiovascular System; Diseases of the Endocrine System; Genetics - Pediatric; Obesity & Weight ControlPrevalence of Carbohydrate Intolerance in Lean and Obese Children