Angelique W. Levi, MD
Associate Professor of Pathology; Vice Chair and Director of Pathology Outreach Services, Pathology
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Research Summary
Dr. Levi’s clinical research and the implementation of automation in Pap test screening in the Yale cytology division has lead to improvements in the Pap test QA/QC program, cytotechnologist workload, laboratory efficiency, and the turn-around-time of Pap test results. Additionally, her clinical research and the implementation of concurrent molecular testing from liquid-based Pap tests has aided in outpatient gynecologic care and clinical management of infectious vaginitis/cervical disease and human papillomavirus-related cervical dysplasia. Building on her previous experience at a private sector pathology laboratory that studied prostate cancer biomarkers with image analysis, her research interests also include prostate cancer pathology and correlation with image analysis.
Coauthors
Selected Publications
- Atypical squamous cells of undetermined significance in liquid-based cytologic specimens: results of reflex human papillomavirus testing and histologic follow-up in routine practice with comparison of interpretive and probabilistic reporting methods.Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid-based cytologic specimens: results of reflex human papillomavirus testing and histologic follow-up in routine practice with comparison of interpretive and probabilistic reporting methods. Cancer 2003, 99: 191-7. PMID: 12925979, DOI: 10.1002/cncr.11507.
- Urinary bladder biopsy with denuded mucosa: denuding cystitis-cytopathologic correlates.Parwani AV, Levi AW, Epstein JI, Ali SZ. Urinary bladder biopsy with denuded mucosa: denuding cystitis-cytopathologic correlates. Diagnostic Cytopathology 2004, 30: 297-300. PMID: 15108225, DOI: 10.1002/dc.10406.
- Prenatal diagnosis of an umbilical vein aneurysm: a case report.Panda B, Stiller R, Iruretagoyena I, Levi A. Prenatal diagnosis of an umbilical vein aneurysm: a case report. Connecticut Medicine 2009, 73: 465-7. PMID: 19777980.
- Comparison of Affirm VPIII and Papanicolaou tests in the detection of infectious vaginitis.Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou tests in the detection of infectious vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-7. PMID: 21350100, DOI: 10.1309/AJCP7TBN5VZUGLZU.
- Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions.Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-34. PMID: 21732551, DOI: 10.1002/cncy.20172.
- Increasing cytotechnologist workload above 100 slides per day using the BD FocalPoint GS imaging system negatively affects screening performance.Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing cytotechnologist workload above 100 slides per day using the BD FocalPoint GS imaging system negatively affects screening performance. American Journal Of Clinical Pathology 2012, 138: 811-5. PMID: 23161714, DOI: 10.1309/AJCPTYDD9G2NCUMF.
- The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology.Wong R, Levi AW, Harigopal M, Schofield K, Chhieng DC. The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology. Archives Of Pathology & Laboratory Medicine 2012, 136: 183-9. PMID: 22288966, DOI: 10.5858/arpa.2011-0139-OA.
- Implementation of FocalPoint GS location-guided imaging system: experience in a clinical setting.Levi AW, Chhieng DC, Schofield K, Kowalski D, Harigopal M. Implementation of FocalPoint GS location-guided imaging system: experience in a clinical setting. Cancer Cytopathology 2012, 120: 126-33. PMID: 22505211, DOI: 10.1002/cncy.20187.
- Comparing two methods of detection for Chlamydia trachomatis in liquid-based Papanicolaou tests.Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing two methods of detection for Chlamydia trachomatis in liquid-based Papanicolaou tests. American Journal Of Clinical Pathology 2012, 138: 236-40. PMID: 22904135, DOI: 10.1309/AJCP2B7XQTCNAMJP.
- Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection.Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection. Cancer Prevention Research (Philadelphia, Pa.) 2014, 7: 526-33. PMID: 24556390, DOI: 10.1158/1940-6207.CAPR-13-0354.
- Prior high-risk human papillomavirus testing and Papanicolaou test results of 70 invasive cervical carcinomas diagnosed in 2012: results of a retrospective multicenter study.Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA. Prior high-risk human papillomavirus testing and Papanicolaou test results of 70 invasive cervical carcinomas diagnosed in 2012: results of a retrospective multicenter study. Archives Of Pathology & Laboratory Medicine 2015, 139: 184-8. PMID: 24694342, DOI: 10.5858/arpa.2014-0028-OA.
- Detection and genotype of high-risk human papillomavirus in fine-needle aspirates of patients with metastatic squamous cell carcinoma is helpful in determining tumor origin.Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and genotype of high-risk human papillomavirus in fine-needle aspirates of patients with metastatic squamous cell carcinoma is helpful in determining tumor origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/AJCPCZA4PSZCFHQ4.
- A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes.Levi AW, Bernstein JI, Hui P, Duch K, Schofield K, Chhieng DC. A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes. Archives Of Pathology & Laboratory Medicine 2016, 140: 153-7. PMID: 26910220, DOI: 10.5858/arpa.2015-0027-OA.
- Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy.Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.
- Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion-targeted biopsy in patients with a solitary PI-RADS v2-scored lesion.Syed JS, Nguyen KA, Nawaf CB, Bhagat AM, Huber S, Levi A, Humphrey P, Weinreb JC, Schulam PG, Sprenkle PC. Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion-targeted biopsy in patients with a solitary PI-RADS v2-scored lesion. Urologic Oncology 2017, 35: 542.e19-542.e24. PMID: 28501565, DOI: 10.1016/j.urolonc.2017.04.011.
- Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies.Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2019, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.
- Mollaret's meningitis: cytopathologic analysis of fourteen cases.Chan TY, Parwani AV, Levi AW, Ali SZ. Mollaret's meningitis: cytopathologic analysis of fourteen cases. Diagnostic Cytopathology 2003, 28: 227-31. PMID: 12722116, DOI: 10.1002/dc.10261.
- Fine needle aspiration cytology of a neck mass.Gilani SM, Levi A. Fine needle aspiration cytology of a neck mass. Cytopathology : Official Journal Of The British Society For Clinical Cytology 2020, 31: 622-623. PMID: 32569432, DOI: 10.1111/cyt.12878.
- High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests.Zuo T, Levi AW, Lin Q, Abi-Raad R, Adeniran AJ, Cai G. High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests. American Journal Of Clinical Pathology 2021, 156: 569-576. PMID: 33728437, DOI: 10.1093/ajcp/aqaa265.
- An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy.Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.
- Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy.Ghabili K, Paulson N, Syed JS, Nawaf CB, Khajir G, Martin DT, Onofrey J, Leapman MS, Levi A, Weinreb JC, Humphrey PA, Sprenkle PC. Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy. Case Reports In Urology 2021, 2021: 2687416. PMID: 33936831, PMCID: PMC8054861, DOI: 10.1155/2021/2687416.
- Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage.Paulson N, Vollmer RT, Humphrey PA, Sprenkle PC, Onofrey J, Huber S, Amirkhiz K, Levi AW. Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage. Archives Of Pathology & Laboratory Medicine 2022, 146: 201-204. PMID: 34015819, DOI: 10.5858/arpa.2020-0568-OA.
- International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer.Wibmer AG, Kattan MW, Alessandrino F, Baur ADJ, Boesen L, Franco FB, Bonekamp D, Campa R, Cash H, Catalá V, Crouzet S, Dinnoo S, Eastham J, Fennessy FM, Ghabili K, Hohenfellner M, Levi AW, Ji X, Løgager V, Margolis DJ, Moldovan PC, Panebianco V, Penzkofer T, Puech P, Radtke JP, Rouvière O, Schlemmer HP, Sprenkle PC, Tempany CM, Vilanova JC, Weinreb J, Hricak H, Shukla-Dave A. International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer. Cancers 2021, 13 PMID: 34071842, PMCID: PMC8198352, DOI: 10.3390/cancers13112627.
- Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale.Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Academic Pathology 2021, 8: 23742895211047985. PMID: 34646939, PMCID: PMC8504692, DOI: 10.1177/23742895211047985.