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Andrey Zinchuk, MD, MHS

Assistant Professor; Director, Advanced Apnea Management Program; Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM; Section of Pulmonary, Critical Care and Sleep Medicine

Contact Information

Andrey Zinchuk, MD, MHS

Research Summary

Research: My goal is to improve the lives of people with sleep disordered breathing. My colleagues and I hope to do so by identifying subgroups (phenotypes) of sleep apnea patients with unique physiology, prognoses and treatment responsiveness. Doing so we anticipate will allow for development of novel, effective and tolerable treatments.

Extensive Research Description

We have identified unique polysomnographic phenotypes of sleep apnea patients using cluster analysis, that are associated with differing clinical characteristics, co-morbid diseases and different rates of incident cardiovascular events or death. Currently, we are working on identifying physiological traits (such as ease with which individuals arouse from sleep) that may predict continuous positive airway pressure (CPAP) responsiveness and contribute to development of cardiovascular disease among some of these patient groups. I am also involved in an NIH sponsored, randomized, comparative effectiveness trial of the impact of usual care, oxygen or CPAP have on ventricular function and cardiopulmonary functional capacity in heart failure with central sleep apnea (a unique phenotype).

Mentors: Klar Yaggi MD, MPH, John Concato, MD, MPH, Andrew Wellman MD, PhD (Harvard).

Coauthors

Research Interests

Cardiovascular Diseases; Sleep Apnea Syndromes; Cluster Analysis; Polysomnography; Sleep Apnea, Central; Continuous Positive Airway Pressure

Selected Publications