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Andrew Wang, MD/PhD, AB

Assistant Professor

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Andrew Wang, MD/PhD, AB

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Yale Medicine

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Extensive Research Description

Abbreviated publications (chronologic):

Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus. J Immunol. 2009 Apr 1; 182(7): 4448-58.

Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst AM, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis Rheum. 2010 Nov; 62(11): 3436-46.

Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 2016 Sep 8; 166(6): 1512-1525

Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medhzitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. PNAS. 2018 Oct 23;115(43):11042-11047.

Wang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science. 2019 Jan 11;363(6423)

Wang A*, Pope S, Weinstein J, Yu S, Zhang C, Booth CJ, Medzhitov R*. Specific Sequences of Infectious Challenge Leads to Secondary Hemophagocytic Lymphohistiocytosis-like Disease in Mice. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2200-2209. * Co-corresponding

Wang A*, Medzhitov R*. Counting Calories: The Cost of Inflammation. Cell 2019 Apr 4;177(2):223-224. *Co-corresponding

Wang A*, Medzhitov R*. Not the usual suspect: type I interferon-responsive T cells drive infection-induced cachexia. Nat Immunol. 2019 Jun;20(6):666-667. *Co-corresponding

Wang A*, Luan HH, Hilliard B, Carvalho F, Rosen C, Ahasic A, Herzog E, Kang I, Pisani M, Yu S, Zhang C, Ring A, Young L, Medzhitov R*. GDF15 is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. 2019. Aug 22;178(5):1231-1244.e11.

Uchendu SN, Wang A* . Less Pain, More Gain: Should Placebo Be a Clinical Therapeutic? Arthritis Rheumatol. 2020. Apr;72(4):511-514.

Qing H, Desrouleaux R, Israni-Winger K, Fogelman N, Zhang C, Rashad S, Palm NW, Sinha R, Piccioto MR, Perry RJ, Wang A* . Origin and function of stress-induced IL6 in murine models. Cell. 2020. Jun 27;S0092-8674(20)30687-5.

Coauthors

Research Interests

Inflammation; Metabolism; Psychoneuroimmunology; Neuroimmunomodulation

Selected Publications

  • CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus.Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 182: 4448-58. PMID: 19299746, PMCID: PMC2946082, DOI: 10.4049/jimmunol.0801920.
  • Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus.Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst AM, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis And Rheumatism 2010, 62: 3436-46. PMID: 20722038, PMCID: PMC8972909, DOI: 10.1002/art.27685.
  • Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell 2016, 166: 1512-1525.e12. PMID: 27610573, PMCID: PMC5555589, DOI: 10.1016/j.cell.2016.07.026.
  • Glucose metabolism mediates disease tolerance in cerebral malaria.Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 11042-11047. PMID: 30291189, PMCID: PMC6205430, DOI: 10.1073/pnas.1806376115.
  • An evolutionary perspective on immunometabolism.Wang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science (New York, N.Y.) 2019, 363 PMID: 30630899, PMCID: PMC6892590, DOI: 10.1126/science.aar3932.
  • Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice.Wang A, Pope SD, Weinstein JS, Yu S, Zhang C, Booth CJ, Medzhitov R. Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 2200-2209. PMID: 30674681, PMCID: PMC6369774, DOI: 10.1073/pnas.1820704116.
  • Counting Calories: The Cost of Inflammation.Wang A, Medzhitov R. Counting Calories: The Cost of Inflammation. Cell 2019, 177: 223-224. PMID: 30951664, DOI: 10.1016/j.cell.2019.03.022.
  • Not the usual suspect: type I interferon-responsive T cells drive infection-induced cachexia.Wang A, Medzhitov R. Not the usual suspect: type I interferon-responsive T cells drive infection-induced cachexia. Nature Immunology 2019, 20: 666-667. PMID: 31110313, DOI: 10.1038/s41590-019-0374-5.
  • GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.Luan HH, Wang A, Hilliard B, Carvalho F, Rosen CE, Ahasic A, Herzog E, Kang I, Pisani MA, Yu S, Zhang C, Ring A, Young L, Medzhitov R. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell 2019, 178: 1231-1244.e11. PMID: 31402172, PMCID: PMC6863354, DOI: 10.1016/j.cell.2019.07.033.
  • Less Pain, More Gain: Should Placebo Be a Clinical Therapeutic?Uchendu SN, Wang A. Less Pain, More Gain: Should Placebo Be a Clinical Therapeutic? Arthritis & Rheumatology (Hoboken, N.J.) 2020, 72: 511-514. PMID: 31729836, DOI: 10.1002/art.41168.
  • Origin and Function of Stress-Induced IL-6 in Murine Models.Qing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 372-387.e14. PMID: 32610084, PMCID: PMC7384974, DOI: 10.1016/j.cell.2020.05.054.

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