Andrew Prendergast, BA, PhD

• Adife Ercan-Sencicek
• Angeliki Louvi
• Bulat A. Ziganshin
• E. Zeynep Erson Omay
• Emma Ristori
• Engin Deniz
• John Elefteriades
• Katsuhito Yasuno
• Kaya Bilguvar
• Ketu Mishra-Gorur
• Kristopher Kahle
• Mohammad Abdullah Zafar
• Murat Gunel
• Mustafa Khokha
• Octavian Henegariu
• Richard Lifton
• Sandip Mukherjee
• Stefania Nicoli

Cardiovascular System; Embryonic and Fetal Development; Neurosciences; Zebrafish; Gene Editing

• Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic AneurysmPrendergast A, Ziganshin BA, Papanikolaou D, Zafar MA, Nicoli S, Mukherjee S, Elefteriades JA. Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm. Genes 2022, 13(1) DOI: 10.3390/genes13010123.
• PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nature Medicine 2021, 27: 2165-2175. PMID: 34887573, PMCID: PMC8768030, DOI: 10.1038/s41591-021-01572-7.
• Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.Desban L, Prendergast A, Roussel J, Rosello M, Geny D, Wyart C, Bardet PL. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology 2019, 17: e3000235. PMID: 31002663, PMCID: PMC6493769, DOI: 10.1371/journal.pbio.3000235.
• Glia: A Gate Controlling Animal Behavior?Wyart C, Prendergast A. Glia: A Gate Controlling Animal Behavior? Current Biology : CB 2019, 29: R847-R850. PMID: 31505186, DOI: 10.1016/j.cub.2019.07.058.
• Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature.Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del'Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9: 3804. PMID: 30228263, PMCID: PMC6143598, DOI: 10.1038/s41467-018-06225-x.
• The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes.Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports 2017, 7: 719. PMID: 28389647, PMCID: PMC5428266, DOI: 10.1038/s41598-017-00350-1.
• Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion.Knafo S, Fidelin K, Prendergast A, Tseng PB, Parrin A, Dickey C, Böhm UL, Figueiredo SN, Thouvenin O, Pascal-Moussellard H, Wyart C. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. ELife 2017, 6 PMID: 28623664, PMCID: PMC5499942, DOI: 10.7554/eLife.25260.
• Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae.Knafo S, Prendergast A, Thouvenin O, Figueiredo SN, Wyart C. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. Bio-protocol 2017, 7: e2550. PMID: 29130058, PMCID: PMC5681248, DOI: 10.21769/BioProtoc.2550.
• Reck enables cerebrovascular development by promoting canonical Wnt signaling.Ulrich F, Carretero-Ortega J, Menéndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, Véliz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-Vázquez J. Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development (Cambridge, England) 2016, 143: 147-59. PMID: 26657775, PMCID: PMC4725199, DOI: 10.1242/dev.123059.
• CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits.Böhm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications 2016, 7: 10866. PMID: 26946992, PMCID: PMC4786674, DOI: 10.1038/ncomms10866.
• Locomotion: Electrical Coupling of Motor and Premotor Neurons.Prendergast A, Wyart C. Locomotion: Electrical Coupling of Motor and Premotor Neurons. Current Biology : CB 2016, 26: R235-7. PMID: 27003886, DOI: 10.1016/j.cub.2016.02.021.
• Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells.Suli A, Pujol R, Cunningham DE, Hailey DW, Prendergast A, Rubel EW, Raible DW. Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells. Journal Of Cell Science 2016, 129: 2250-60. PMID: 27103160, PMCID: PMC4920245, DOI: 10.1242/jcs.182592.
• Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy.Rupprecht P, Prendergast A, Wyart C, Friedrich RW. Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy. Biomedical Optics Express 2016, 7: 1656-71. PMID: 27231612, PMCID: PMC4871072, DOI: 10.1364/BOE.7.001656.
• Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion.Hubbard JM, Böhm UL, Prendergast A, Tseng PB, Newman M, Stokes C, Wyart C. Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Current Biology : CB 2016, 26: 2841-2853. PMID: 27720623, DOI: 10.1016/j.cub.2016.08.026.
• State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons.Fidelin K, Djenoune L, Stokes C, Prendergast A, Gomez J, Baradel A, Del Bene F, Wyart C. State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Current Biology : CB 2015, 25: 3035-47. PMID: 26752076, DOI: 10.1016/j.cub.2015.09.070.
• The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.Prendergast A, Linbo TH, Swarts T, Ungos JM, McGraw HF, Krispin S, Weinstein BM, Raible DW. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development (Cambridge, England) 2012, 139: 1141-52. PMID: 22296847, PMCID: PMC3283124, DOI: 10.1242/dev.072439.
• Postembryonic neuronal addition in zebrafish dorsal root ganglia is regulated by Notch signaling.McGraw HF, Snelson CD, Prendergast A, Suli A, Raible DW. Postembryonic neuronal addition in zebrafish dorsal root ganglia is regulated by Notch signaling. Neural Development 2012, 7: 23. PMID: 22738203, PMCID: PMC3438120, DOI: 10.1186/1749-8104-7-23.
• Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest.Curran K, Lister JA, Kunkel GR, Prendergast A, Parichy DM, Raible DW. Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Developmental Biology 2010, 344: 107-18. PMID: 20460180, PMCID: PMC2909359, DOI: 10.1016/j.ydbio.2010.04.023.
• Man is but a worm: chordate origins.Brown FD, Prendergast A, Swalla BJ. Man is but a worm: chordate origins. Genesis (New York, N.Y. : 2000) 2008, 46: 605-13. PMID: 19003926, DOI: 10.1002/dvg.20471.
• Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm.Prendergast A, Ziganshin BA, Papanikolaou D, Zafar MA, Nicoli S, Mukherjee S, Elefteriades JA. Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm. Genes 2022, 13 PMID: 35052463, PMCID: PMC8775119, DOI: 10.3390/genes13010123.