2015
Heart rate and respiratory response to doxapram in patients with panic disorder
Martinez JM, Garakani A, Aaronson CJ, Gorman JM. Heart rate and respiratory response to doxapram in patients with panic disorder. Psychiatry Research 2015, 227: 32-38. PMID: 25819170, PMCID: PMC4420657, DOI: 10.1016/j.psychres.2015.03.001.Peer-Reviewed Original ResearchConceptsPD patientsLF/HFPanic disorderHealthy controlsAnticipatory anxietyPD subjectsParasympathetic componentRespiratory responsesLF/HF ratioSensation of dyspneaHeart rate variability indicesHigher sympathetic activityInjection of salinePanic statesSympathetic activityRespiratory abnormalitiesBrain stemRespiratory stimulantHeart rateParasympathetic responsePanic attacksPatientsExaggerated fear responsePanic symptomsHF ratio
2010
Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients
Martinez JM, Garakani A, Kaufmann H, Aaronson CJ, Gorman JM. Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients. Psychosomatic Medicine 2010, 72: 442-449. PMID: 20368476, DOI: 10.1097/psy.0b013e3181d972c2.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityMean diastolic blood pressureHigher heart rateHeart rate variabilityDiastolic blood pressureBlood pressureHealthy controlsHeart ratePanic disorder patientsPD patientsLF/HFOrthostatic challengeSympathovagal balanceDisorder patientsHigher mean diastolic blood pressureGreater cardiac riskIllness severity ratingsLess ill patientsSystolic blood pressureBlood pressure changesSeverity of illnessHigher low-frequency componentsAutonomic nervous systemIll patientsCardiac risk
2008
Effect of medication and psychotherapy on heart rate variability in panic disorder
Garakani A, Martinez JM, Aaronson CJ, Voustianiouk A, Kaufmann H, Gorman JM. Effect of medication and psychotherapy on heart rate variability in panic disorder. Depression And Anxiety 2008, 26: 251-258. PMID: 18839407, DOI: 10.1002/da.20533.Peer-Reviewed Original ResearchConceptsHeart rate variabilityHeart rateRate variabilityLower heart rate variabilitySignificant clinical improvementWeeks of treatmentWeeks of CBTEffects of medicationPanic disorder patientsEffect of treatmentClinical improvementCardiac riskPD patientsCardiovascular diseaseTreatment respondersClinical measuresElevated riskDisorder patientsTreatment phasePatientsSymptom reductionPanic disorderHyperventilation challengeStatistical ManualSignificant decrease
2007
The effect of doxapram on brain imaging in patients with panic disorder
Garakani A, Buchsbaum MS, Newmark RE, Goodman C, Aaronson CJ, Martinez JM, Torosjan Y, Chu KW, Gorman JM. The effect of doxapram on brain imaging in patients with panic disorder. European Neuropsychopharmacology 2007, 17: 672-686. PMID: 17560768, PMCID: PMC2695988, DOI: 10.1016/j.euroneuro.2007.04.002.Peer-Reviewed Original ResearchConceptsPanic disorder patientsDisorder patientsPlacebo saline solutionEffects of doxapramNormal control subjectsHeart rate increasePositron emission tomographyGreater heart rate increasePlacebo dayControl subjectsRespiratory stimulantCingulate gyrusDoxapramNormal volunteersPatientsPanic patientsPanic attacksPanic disorderDoxapram hydrochlorideSeparate daysEmission tomographyInhibitory centersFunctional imagingAmygdala activityCounterbalanced order
2006
Neurobiology of anxiety disorders and implications for treatment.
Garakani A, Mathew SJ, Charney DS. Neurobiology of anxiety disorders and implications for treatment. Annals Of Global Health 2006, 73: 941-9. PMID: 17195879.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-traumatic stress disorderCognitive behavioral therapyFear conditioningUnconditioned stimulusAnxiety disordersPartial NMDA agonistFear inhibitionFear extinctionTraumatic memoriesFear circuitryFear responsesPavlovian conditioningBehavioral therapyStress disorderSpecific phobiaNew learningAmygdala pathwayD-cycloserineAnti-anxiety treatmentPanic disorderPreliminary evidenceStimuliMemoryN-methyl-D-aspartate antagonistsNeurobiology