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Amanda Kallen, MD

Associate Professor of Obstetrics, Gynecology and Reproductive Sciences

Contact Information

Amanda Kallen, MD

Mailing Address

  • Obstetrics, Gynecology & Reproductive Sciences

    333 Cedar St, PO Box 208063

    New Haven, CT 06510

    United States

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Yale Medicine

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Research Summary

My current research program aims to improve our understanding of the regulatory mechanisms underlying follicular development and reproductive aging in the mammalian ovary. Over the last several years, noncoding RNAs (ncRNAs) have emerged as master regulators of tissue growth and differentiation, and my work has focused on these ncRNAs and their role in the reproductive tract. During my Reproductive Endocrinology and Infertility fellowship, I was awarded a position in the NICHD’s Reproductive Scientist Development Program, a prestigious mentored career development program whose goal is to develop academic reproductive physician-scientists equipped with the skills to address important problems in the field of obstetrics and gynecology. This was a transformative experience, allowing me to use my background as a physician to better understand reproduction at the cellular and molecular level, as well as to understand the importance of research that could translate from bench to bedside. Our laboratory was the first to demonstrate that the long ncRNA H19 acts as a molecular “sponge” for the micro RNA let-7; this work was published in Molecular Cell and has been cited over 580 times. More recently, we have described novel, noncoding-RNA-mediated mechanisms for regulation of follicular recruitment as well as for the rate-limiting step of steroidogenesis; the latter resulted in a manuscript which was recognized by the Endocrine Society as one of the "Top Endocrine Discoveries of 2017". Since completion of the RSDP, I have received the American Society for Reproductive Medicine Research Grant and the 2020 Society for Reproductive Investigation “Early Career Investigator” Award for my work on mechanisms of reproductive aging. I am currently the PI on an R01 which aims to investigate noncoding RNA-mediated regulation of ovarian follicular quantity and quality, a novel and understudied area of ovarian aging, and which received an Impact Score of 10 (1st percentile).

Coauthors

Research Interests

Granulosa Cells; Gynecology; Infertility; Ovary; Reproductive Medicine; MicroRNAs; RNA, Long Noncoding

Selected Publications

  • The imprinted H19 lncRNA antagonizes let-7 microRNAs.Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Molecular Cell 2013, 52: 101-12. PMID: 24055342, PMCID: PMC3843377, DOI: 10.1016/j.molcel.2013.08.027.
  • A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19/let-7 axis.Qin C, Xia X, Fan Y, Jiang Y, Chen Y, Zhang N, Uslu B, Johnson J, Kallen AN. A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19/let-7 axis. Biology Of Reproduction 2019, 101: 257. PMID: 31286140, PMCID: PMC6614579, DOI: 10.1093/biolre/ioz046.
  • The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis.Men Y, Fan Y, Shen Y, Lu L, Kallen AN. The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis. Endocrinology 2017, 158: 402-409. PMID: 27813675, PMCID: PMC5413078, DOI: 10.1210/en.2016-1340.
  • The relationship between H19 and parameters of ovarian reserve.Xia X, Burn MS, Chen Y, Karakaya C, Kallen A. The relationship between H19 and parameters of ovarian reserve. Reproductive Biology And Endocrinology : RB&E 2020, 18: 46. PMID: 32404103, PMCID: PMC7218823, DOI: 10.1186/s12958-020-00578-z.
  • Absence of the long noncoding RNA H19 results in aberrant ovarian STAR and progesterone production.Chen Y, Wang J, Fan Y, Qin C, Xia X, Johnson J, Kallen A. Absence of the long noncoding RNA H19 results in aberrant ovarian STAR and progesterone production. Molecular And Cellular Endocrinology 2019, 490: 15-20. PMID: 30922932, PMCID: PMC6774754, DOI: 10.1016/j.mce.2019.03.009.
  • Emerging roles for noncoding RNAs in female sex steroids and reproductive disease.Zhang R, Wesevich V, Chen Z, Zhang D, Kallen AN. Emerging roles for noncoding RNAs in female sex steroids and reproductive disease. Molecular And Cellular Endocrinology 2020, 518: 110875. PMID: 32668269, PMCID: PMC7609472, DOI: 10.1016/j.mce.2020.110875.
  • Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells.Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-76.e1-3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.
  • Updates on molecular and environmental determinants of luteal progesterone production.DeWitt NA, Whirledge S, Kallen AN. Updates on molecular and environmental determinants of luteal progesterone production. Molecular And Cellular Endocrinology 2020, 515: 110930. PMID: 32610113, PMCID: PMC7484338, DOI: 10.1016/j.mce.2020.110930.
  • Untapped Reserves: Controlling Primordial Follicle Growth Activation.Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.
  • HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling.Kallen AN, Haines K, Taylor HS. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. Reproductive Sciences (Thousand Oaks, Calif.) 2014, 21: 892-897. PMID: 24532216, PMCID: PMC4107567, DOI: 10.1177/1933719113519168.
  • Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling.Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling. Reproductive Sciences (Thousand Oaks, Calif.) 2020, 27: 2063-2074. PMID: 32542534, PMCID: PMC7529825, DOI: 10.1007/s43032-020-00225-3.
  • Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?Kallen AN, Ma J, Huang Y. Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs? Frontiers In Genetics 2012, 3: 240. PMID: 23162570, PMCID: PMC3499807, DOI: 10.3389/fgene.2012.00240.
  • Endothelin type A receptor (ETA) expression is regulated by HOXA10 in human endometrial stromal cells.Penna IA, Hongling Du, Kallen AN, Taylor HS. Endothelin type A receptor (ETA) expression is regulated by HOXA10 in human endometrial stromal cells. Reproductive Sciences (Thousand Oaks, Calif.) 2010, 17: 471-6. PMID: 20371740, PMCID: PMC3107845, DOI: 10.1177/1933719110361961.
  • Gender differences in cardiovascular disease: hormonal and biochemical influences.Pérez-López FR, Larrad-Mur L, Kallen A, Chedraui P, Taylor HS. Gender differences in cardiovascular disease: hormonal and biochemical influences. Reproductive Sciences (Thousand Oaks, Calif.) 2010, 17: 511-31. PMID: 20460551, PMCID: PMC3107852, DOI: 10.1177/1933719110367829.
  • Blood type predicts live birth in the infertile population.Goldsammler M, Jindal SK, Kallen A, Mmbaga N, Pal L. Blood type predicts live birth in the infertile population. Journal Of Assisted Reproduction And Genetics 2015, 32: 551-5. PMID: 25701141, PMCID: PMC4380903, DOI: 10.1007/s10815-015-0441-2.
  • A counterintuitive lesson in family planning? Patience first: taking a "gap year" after live birth from assisted reproductive technology before frozen embryo transfer is performed.Seifer DB, Kallen AN. A counterintuitive lesson in family planning? Patience first: taking a "gap year" after live birth from assisted reproductive technology before frozen embryo transfer is performed. Fertility And Sterility 2019, 111: 1109-1110. PMID: 31056317, DOI: 10.1016/j.fertnstert.2019.03.017.
  • Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB).Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.
  • Aberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report.Kallen AN, Luk J, Pal L. Aberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report. The Journal Of Reproductive Medicine 2013, 58: 256-60. PMID: 23763012.
  • Cardiovascular disease and ovarian function.Kallen AN, Pal L. Cardiovascular disease and ovarian function. Current Opinion In Obstetrics & Gynecology 2011, 23: 258-67. PMID: 21681091, DOI: 10.1097/GCO.0b013e3283488a21.
  • Hormone therapy: A to Z.Fischer C, Kallen AN, Pal L. Hormone therapy: A to Z. Menopause (New York, N.Y.) 2013, 20: 1204-6. PMID: 23921519, DOI: 10.1097/GME.0b013e31829cd38d.

Clinical Trials

ConditionsStudy Title
Women's HealthPre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis (PREGnant)
Diseases of the Digestive System - Liver; Women's HealthPharmacokinetics and Hepatic Safety of EGCG
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