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Alfred Lee, MD, PhD

Associate Professor of Medicine (Hematology); Director, Hematology/Oncology Fellowship Program

Contact Information

Alfred Lee, MD, PhD

Mailing Address

  • Hematology

    333 Cedar Street, PO Box 208028

    New Haven, CT 06520-8028

    United States

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Yale Medicine

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Coauthors

Selected Publications

  • American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis.Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, Davila J, DeSancho MT, Diuguid D, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo KM, Siegal D, Skara M, Terrell DR, Touri K, Akl EA, Al Jabiri RN, Al Jabiri YN, Barbara AM, Bognanni A, Bou Akl I, Boulos M, Brignardello-Petersen R, Charide R, Chan M, Colunga-Lozano LE, Dearness K, Darzi AJ, Hussein H, Karam SG, Kolb P, Mansour R, Morgano GP, Morsi RZ, Muti-Schünemann G, Nadim MK, Noori A, Philip BA, Piggott T, Qiu Y, Benitez YR, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa RA, Schünemann HJ. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis. Blood Advances 2022, 6: 664-671. PMID: 34727173, PMCID: PMC8566097, DOI: 10.1182/bloodadvances.2021005945.
  • Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura.Goshua G, Sinha P, Hendrickson JE, Tormey CA, Bendapudi PK, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2021, 137: 969-976. PMID: 33280030, PMCID: PMC7918179, DOI: 10.1182/blood.2020006052.
  • A Brewing Back Pain.Pischel L, Geirsson A, Magaldi J, Martinello RA, Lee AI. A Brewing Back Pain. The New England Journal Of Medicine 2021, 385: 66-72. PMID: 34192434, DOI: 10.1056/NEJMcps2034802.
  • Cerebral venous sinus thrombosis after vaccination: the UK experience.Lee EJ, Lee AI. Cerebral venous sinus thrombosis after vaccination: the UK experience. Lancet 2021, 398: 1107-1109. PMID: 34370974, PMCID: PMC8346246, DOI: 10.1016/S0140-6736(21)01788-8.
  • SARS-CoV-2 vaccination and ITP in patients with de novo or preexisting ITP.Lee EJ, Beltrami-Moreira M, Al-Samkari H, Cuker A, DiRaimo J, Gernsheimer T, Kruse A, Kessler C, Kruse C, Leavitt AD, Lee AI, Liebman HA, Newland AC, Ray AE, Tarantino MD, Thachil J, Kuter DJ, Cines DB, Bussel JB. SARS-CoV-2 vaccination and ITP in patients with de novo or preexisting ITP. Blood 2022, 139: 1564-1574. PMID: 34587251, PMCID: PMC8483984, DOI: 10.1182/blood.2021013411.
  • Cryptic Cachexia.Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. The New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/NEJMcps1817531.
  • Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet. Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/S2352-3026(20)30216-7.
  • Trends and factors affecting the US adult hematology workforce: a mixed methods study.Sharma D, Wallace N, Levinsohn EA, Marshall AL, Kayoumi K, Madero J, Homer M, Reynolds R, Hafler J, Podoltsev NA, Lee AI. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Advances 2019, 3: 3550-3561. PMID: 31738829, PMCID: PMC6880914, DOI: 10.1182/bloodadvances.2019000307.
  • Associations between hematology/oncology fellows' training and mentorship experiences and hematology-only career plans.Masselink LE, Erikson CE, Connell NT, De Castro LM, Dent GA, Marshall AL, Naik RP, Nelson M, O'Connell CL, Rajasekhar A, Sharma D, Smith M, Lee AI. Associations between hematology/oncology fellows' training and mentorship experiences and hematology-only career plans. Blood Advances 2019, 3: 3278-3286. PMID: 31698456, PMCID: PMC6855099, DOI: 10.1182/bloodadvances.2019000569.
  • The next(gen) step in coagulation testing.Lee AI, Connors JM. The next(gen) step in coagulation testing. Blood 2019, 134: 2002-2003. PMID: 31805193, DOI: 10.1182/blood.2019001414.
  • A novel approach to the program evaluation committee.Schwartz AR, Siegel MD, Lee AI. A novel approach to the program evaluation committee. BMC Medical Education 2019, 19: 465. PMID: 31842868, PMCID: PMC6916454, DOI: 10.1186/s12909-019-1899-x.
  • Evaluation of Polycythemia: A Teachable Moment.Djulbegovic M, Dugdale LS, Lee AI. Evaluation of Polycythemia: A Teachable Moment. JAMA Internal Medicine 2018, 178: 128-130. PMID: 29131894, DOI: 10.1001/jamainternmed.2017.6213.
  • Whole-exome sequencing in evaluation of patients with venous thromboembolism.Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.
  • CLINICAL PROBLEM-SOLVING. The Hidden Lesion.Lee AI, Ochoa Chaar CI. CLINICAL PROBLEM-SOLVING. The Hidden Lesion. The New England Journal Of Medicine 2016, 374: 2160-5. PMID: 27248622, DOI: 10.1056/NEJMcps1406615.
  • Clinical problem-solving. Venting the spleen.Varughese N, Duong A, Emre S, Xu M, Lee AI. Clinical problem-solving. Venting the spleen. The New England Journal Of Medicine 2013, 369: 1357-63. PMID: 24088096, DOI: 10.1056/NEJMcps1210943.
  • Clinical problem-solving. A bird's-eye view of fever.Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. Clinical problem-solving. A bird's-eye view of fever. The New England Journal Of Medicine 2011, 365: 1727-32. PMID: 22047564, DOI: 10.1056/NEJMcps1012518.
  • A patient with oxaliplatin immune-induced syndrome (OIIS) who also developed leucovorin and palonosetron-associated thrombocytopenia.Curtis SA, Curtis BR, Lee AI, Hendrickson JE, Lacy J, Podoltsev NA. A patient with oxaliplatin immune-induced syndrome (OIIS) who also developed leucovorin and palonosetron-associated thrombocytopenia. Hematology (Amsterdam, Netherlands) 2018, 23: 429-432. PMID: 29281948, DOI: 10.1080/10245332.2017.1419600.
  • Impact of COVID-19 on Hematology-Oncology Trainees: A Quantitative and Qualitative Assessment.Durani U, Major A, Velazquez AI, May J, Nelson M, Zheng Z, Hall AG, Alam ST, Reynolds R, Thompson JC, Kumbamu A, Das DG, Murphy MC, Henry E, Lee AI, Marshall AL, Wun T, Weeks LD. Impact of COVID-19 on Hematology-Oncology Trainees: A Quantitative and Qualitative Assessment. JCO Oncology Practice 2022, 18: e586-e599. PMID: 34990292, PMCID: PMC9014488, DOI: 10.1200/OP.21.00630.
  • Impact of COVID-19 on Hematology-Oncology Fellowship Programs: A Quantitative and Qualitative Survey Assessment of Fellowship Program Directors.Velazquez AI, Durani U, Weeks LD, Major A, Reynolds R, Kumbamu A, Das DG, Murphy MC, Henry E, Lee AI, Marshall AL. Impact of COVID-19 on Hematology-Oncology Fellowship Programs: A Quantitative and Qualitative Survey Assessment of Fellowship Program Directors. JCO Oncology Practice 2022, 18: e551-e563. PMID: 35015586, PMCID: PMC9014421, DOI: 10.1200/OP.21.00634.
  • Clinical characteristics, time course, and outcomes of major bleeding according to bleeding site in patients with venous thromboembolism.Bikdeli B, Moustafa F, Nieto JA, Lee AI, Ruíz-Giménez N, Lorenzo A, Schellong S, Soler S, Ortíz S, Morales MDV, Bosevski M, Gavín O, Lip GYH, Monreal M. Clinical characteristics, time course, and outcomes of major bleeding according to bleeding site in patients with venous thromboembolism. Thrombosis Research 2022, 211: 10-18. PMID: 35051831, PMCID: PMC8891056, DOI: 10.1016/j.thromres.2022.01.007.
  • Cost-effectiveness of second-line therapies in adults with chronic immune thrombocytopenia.Goshua G, Sinha P, Kunst N, Pischel L, Lee AI, Cuker A. Cost-effectiveness of second-line therapies in adults with chronic immune thrombocytopenia. American Journal Of Hematology 2022 PMID: 35147241, DOI: 10.1002/ajh.26497.
  • Association of renalase with clinical outcomes in hospitalized patients with COVID-19.Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PloS One 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
  • Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.Streiff MB, Holmstrom B, Angelini D, Ashrani A, Elshoury A, Fanikos J, Fertrin KY, Fogerty AE, Gao S, Goldhaber SZ, Gundabolu K, Ibrahim I, Kraut E, Leavitt AD, Lee A, Lee JT, Lim M, Mann J, Martin K, McMahon B, Moriarty J, Morton C, Ortel TL, Paschal R, Schaefer J, Shattil S, Siddiqi T, Sudheendra D, Williams E, Hollinger L, Nguyen MQ. Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2021, 19: 1181-1201. PMID: 34666313, DOI: 10.6004/jnccn.2021.0047.
  • Burnout in U.S. hematologists and oncologists: impact of compensation models and advanced practice provider support.Lee AI, Masselink LE, De Castro LM, Marshall AL, Connell NT, Dent GA, Fritz J, Homer MR, Lucas TL, Naik RP, Nelson M, O'Connell CL, Rajasekhar A, Reynolds RJ, Sharma D, Smith M, Weeks LD, Erikson CE. Burnout in U.S. hematologists and oncologists: impact of compensation models and advanced practice provider support. Blood Advances 2022 PMID: 35476017, DOI: 10.1182/bloodadvances.2021006140.
  • The case for classical haematology: the impact of a name and the future of a field.Al-Samkari H, Loren AW, Lee AI. The case for classical haematology: the impact of a name and the future of a field. The Lancet. Haematology 2022 PMID: 35500590, DOI: 10.1016/S2352-3026(22)00096-5.
  • Sex differences in long-term outcomes of patients with deep vein thrombosis.Chan SM, Brahmandam A, Valcarce-Aspegren M, Zhuo H, Zhang Y, Tonnessen BH, Lee AI, Ochoa Chaar CI. Sex differences in long-term outcomes of patients with deep vein thrombosis. Vascular 2022, 17085381221097746. PMID: 35502988, DOI: 10.1177/17085381221097746.
  • American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients.Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, DeSancho MT, Diuguid DL, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo K, Siegal DM, Skara M, Terrell DR, Touri K, Akl EA, Al Jabiri RN, Al Jabiri YN, Barbara AM, Bognanni A, Boulos M, Brignardello-Petersen R, Charide R, Colunga-Lozano LE, Dearness KL, Darzi AJ, Hussein H, Karam SG, Mansour R, Morgano GP, Morsi RZ, Muti-Schünemann G, Nadim MK, Philip BA, Qiu Y, Benitez YR, Stevens A, Solo K, Wiercioch W, Mustafa RA, Schünemann HJ. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients. Blood Advances 2022 PMID: 35503027, PMCID: PMC9068240, DOI: 10.1182/bloodadvances.2022007561.
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