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Alfred Kaye, MD, PhD

Assistant Professor of Psychiatry; Researcher, VA-Yale Clinical Neurosciences PTSD Research Program

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Alfred Kaye, MD, PhD

Research Summary

Dr. Kaye is an Assistant Professor of Psychiatry, using a combination of circuit and computational approaches to understand adaptations to the danger in the environment and how those adaptations underlie PTSD. He graduated from the University of California M.D., Ph.D. program, where he used two-photon imaging and computational modeling to understand the organization of visual motion processing. Then, he joined the psychiatry residency at Yale, where he worked in Alex Kwan's lab on using calcium and neurotransmitter imaging to understand how arousal states change after stress, and also developed computational models of PTSD.

The lab will focus on understanding how neuromodulatory circuits reprogram one another to create adaptive responses to traumatic experiences. Underlying this idea is the central problem of developing a mechanistic and functional understanding of stress and anxiety. The lab uses microendoscope and two-photon imaging of calcium and neurotransmitter sensors, large-scale electrophysiology (Neuropixels), computational analysis of behavior (DeepLabCut), and single cell transcriptomics to understand this problem.

Research Interests

Neurosciences; Norepinephrine; Psychiatry