2024
Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.
Shin J, Park J, Lim J, Jeong J, Dinesh R, Maher S, Kim J, Park S, Hong J, Wysolmerski J, Choi J, Bothwell A. Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties. ELife 2024, 13 PMID: 39535280, PMCID: PMC11560131, DOI: 10.7554/elife.97279.Peer-Reviewed Original ResearchConceptsCancer cellsDickkopf-2Analysis of transcriptomeGeneration of cancer cellsPositive cancer cellsStem cell niche factorsColon cancer cellsPaneth cell differentiationHepatocyte nuclear factor 4 alphaLysozyme positive cellsChromatin accessibilityHNF4A proteinSingle-cell RNA sequencing analysisCell propertiesPaneth cell markersSequence analysisChromatin immunoprecipitationPromoter regionTranscription factorsTranscriptome analysisColon cancerColon cancer metastasisReduction of liver metastasisDownstream targetsCell differentiationMetastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties
Shin J, Park J, Lim J, Jeong J, Dinesh R, Maher S, Kim J, Park S, Hong J, Wysolmerski J, Choi J, Bothwell A. Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties. ELife 2024, 13 DOI: 10.7554/elife.97279.3.Peer-Reviewed Original ResearchCancer cellsDickkopf-2Promoter region of Sox9Analysis of transcriptomeGeneration of cancer cellsPositive cancer cellsStem cell niche factorsColon cancer cellsPaneth cell differentiationHepatocyte nuclear factor 4 alphaLysozyme positive cellsChromatin accessibilityHNF4A proteinSingle-cell RNA sequencing analysisCell propertiesPaneth cell markersSequence analysisChromatin immunoprecipitationPromoter regionTranscription factorsTranscriptome analysisColon cancerColon cancer metastasisReduction of liver metastasisDownstream targets
1990
Characterization Of Promoter Elements Of An Interferon-Inducible Ly-6E/A Differentiation Antigen, Which Is Expressed On Activated T Cells And Hematopoietic Stem Cells
Khan K, Lindwall G, Maher S, Bothwell A. Characterization Of Promoter Elements Of An Interferon-Inducible Ly-6E/A Differentiation Antigen, Which Is Expressed On Activated T Cells And Hematopoietic Stem Cells. Molecular And Cellular Biology 1990, 10: 5150-5159. DOI: 10.1128/mcb.10.10.5150-5159.1990.Peer-Reviewed Original ResearchLy-6CCAAT box-binding proteinGenomic DNA clonesInterferon-stimulated response elementElectrophoretic mobility shift assayCis-acting elementsCrude nuclear extractsInterferon-inducible promoterLy-6 genesChloramphenicol acetyltransferase geneMobility shift assayChloramphenicol acetyltransferase assayGenomic clonesBALB/3T3 cellsCharacterized cDNAsDNA clonesPromoter elementsDNA sequencesAcetyltransferase geneEnhancer elementsNuclear extractsPromoter regionActivated murine T cellsShift assaysAcetyltransferase assay