2019
Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation
Chae WJ, Bothwell ALM. Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation. Differentiation 2019, 108: 33-39. PMID: 31221431, PMCID: PMC6982462, DOI: 10.1016/j.diff.2019.05.003.Peer-Reviewed Original ResearchConceptsCell proliferationPro-inflammatory ligandsRole of DKK1Pro-inflammatory roleRepair processPoor disease outcomeOrgan homeostasisTransduction pathwaysCanonical WntCell differentiationTissue repair processMulticellular interactionsOrgan injuryCell typesInflammatory diseasesTissue injuryDisease outcomeImmune responseWntBone diseaseWnt antagonistsPathological inflammationMusculoskeletal diseasesExpression levelsDickkopf1
2006
Manganese Treatment Modulates the Expression of Peroxisome Proliferator-activated Receptors in Astrocytoma and Neuroblastoma Cells
Isaac AO, Kawikova I, Bothwell AL, Daniels CK, Lai JC. Manganese Treatment Modulates the Expression of Peroxisome Proliferator-activated Receptors in Astrocytoma and Neuroblastoma Cells. Neurochemical Research 2006, 31: 1305-1316. PMID: 17053972, DOI: 10.1007/s11064-006-9173-0.Peer-Reviewed Original ResearchConceptsPeroxisome proliferator-activated receptorMn neurotoxicityPPAR isoformsExpression of PPARsNeuroblastoma cellsProliferator-activated receptorAnti-oxidant responseCell typesChronic exposureNeurotoxic mechanismsPeroxisome proliferatorPathophysiological importanceHuman astrocytomasNeural cellsNeurotoxicityManganese chloride treatmentProtein expressionCell proliferationAstrocytomasManganese treatmentReceptorsMolecular mechanismsTreatmentCytosolic fractionCells