Alexa Siddon, MD
Associate Professor Term; Hematopathology Fellowship Director, Laboratory Medicine; Director, Molecular Diagnostics Laboratory, Laboratory Medicine; Director, Flow Cytometry, Laboratory Medicine; Associate Director, Hematology Laboratory, Laboratory Medicine
Research & Publications
Biography
News
Locations
Coauthors
Selected Publications
- Pathology consultation on evaluating prognosis in incidental monoclonal lymphocytosis and chronic lymphocytic leukemia.Siddon AJ, Rinder HM. Pathology consultation on evaluating prognosis in incidental monoclonal lymphocytosis and chronic lymphocytic leukemia. American Journal Of Clinical Pathology 2013, 139: 708-12. PMID: 23690112, DOI: 10.1309/AJCPLIR4GZWX3XKA.
- Human herpesvirus 6 positive Reed-Sternberg cells in nodular sclerosis Hodgkin lymphoma.Siddon A, Lozovatsky L, Mohamed A, Hudnall SD. Human herpesvirus 6 positive Reed-Sternberg cells in nodular sclerosis Hodgkin lymphoma. British Journal Of Haematology 2012, 158: 635-43. PMID: 22757777, DOI: 10.1111/j.1365-2141.2012.09206.x.
- Normalized CCND1 expression has prognostic value in mantle cell lymphoma.Siddon AJ, Torres R, Rinder HM, Smith BR, Howe JG, Tormey CA. Normalized CCND1 expression has prognostic value in mantle cell lymphoma. British Journal Of Haematology 2012, 158: 551-3. PMID: 22671703, DOI: 10.1111/j.1365-2141.2012.09181.x.
- Pathology Consultation on Gene Mutations in Acute Myeloid Leukemia.Ziai JM, Siddon AJ. Pathology Consultation on Gene Mutations in Acute Myeloid Leukemia. American Journal Of Clinical Pathology 2015, 144: 539-54. PMID: 26386075, DOI: 10.1309/AJCP77ZFPUQGYGWY.
- Multi-system complications of hypereosinophilia.Stahl M, Mohareb AM, Lee AI, Federman DG, Siddon AJ, Spelman J. Multi-system complications of hypereosinophilia. American Journal Of Hematology 2016, 91: 444-7. PMID: 26700720, DOI: 10.1002/ajh.24283.
- False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab: Potential Pitfalls for the Misdiagnosis of B-Cell Neoplasms.Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab: Potential Pitfalls for the Misdiagnosis of B-Cell Neoplasms. American Journal Of Clinical Pathology 2019, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.
- Use of B-Cell Gene Rearrangement Studies to Establish Clonality in Non-producer Non-secretory Multiple Myeloma.Mendoza H, Tormey CA, Siddon AJ. Use of B-Cell Gene Rearrangement Studies to Establish Clonality in Non-producer Non-secretory Multiple Myeloma. Clinical Lymphoma, Myeloma & Leukemia 2020, 20: e18-e21. PMID: 31711890, DOI: 10.1016/j.clml.2019.10.012.
- Isolated trisomy 11 in patients with acute myeloid leukemia - is the prognosis not as grim as previously thought?Bewersdorf JP, Shallis RM, Diadamo A, Gowda L, Podoltsev NA, Siddon A, Zeidan AM. Isolated trisomy 11 in patients with acute myeloid leukemia - is the prognosis not as grim as previously thought? Leukemia & Lymphoma 2020, 61: 2254-2257. PMID: 32338096, PMCID: PMC7485109, DOI: 10.1080/10428194.2020.1755858.
- The Development and Implementation of a Novel Electronic Consult System by a Laboratory Medicine Service: Experience From the First 2 Years of Use.Stendahl K, Siddon AJ, Peaper DR, Hauser RG, Campbell S, Tormey CA. The Development and Implementation of a Novel Electronic Consult System by a Laboratory Medicine Service: Experience From the First 2 Years of Use. Archives Of Pathology & Laboratory Medicine 2020 PMID: 32338535, DOI: 10.5858/arpa.2019-0267-OA.
- Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience.Bewersdorf JP, Shallis RM, Gowda L, Wei W, Hager K, Isufi I, Kim TK, Pillai MM, Seropian S, Podoltsev NA, Gore SD, Siddon AJ, Zeidan AM. Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. Leukemia & Lymphoma 2020, 61: 2180-2190. PMID: 32362171, PMCID: PMC7603787, DOI: 10.1080/10428194.2020.1759051.
- Glial heterotopia of the uterine cervix: DNA genotyping confirmation of its fetal origin.Siddon A, Hui P. Glial heterotopia of the uterine cervix: DNA genotyping confirmation of its fetal origin. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists 2010, 29: 394-7. PMID: 20567155, DOI: 10.1097/PGP.0b013e3181c5a7e8.
- Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia.Abi Raad R, Tormey CA, Siddon AJ. Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. Transfusion 2014, 54: 970. PMID: 24724788, DOI: 10.1111/trf.12384.
- Cardiac FDG-PET to assess sarcoidosis in a cardiac allograft.Chen A, Khanna P, Siddon A, Russell R. Cardiac FDG-PET to assess sarcoidosis in a cardiac allograft. Clinical Nuclear Medicine 2014, 39: 54-6. PMID: 23603601, DOI: 10.1097/RLU.0b013e318279ffc7.
- Hemoglobinopathy Screening in a 15-Year-old Patient With Anemia.Honarpisheh H, Staba Hogan MJ, Rinder HM, Siddon AJ. Hemoglobinopathy Screening in a 15-Year-old Patient With Anemia. Journal Of Pediatric Hematology/oncology 2015, 37: 472-3. PMID: 26181419, DOI: 10.1097/MPH.0000000000000357.
- Is thrombin time too sensitive to dabigatran anticoagulation for clinical decision making in the setting of acute hemorrhage?Siddon AJ, Rinder HM, Hendrickson JE, Tormey CA. Is thrombin time too sensitive to dabigatran anticoagulation for clinical decision making in the setting of acute hemorrhage? Annals Of Hematology 2015, 94: 1413-4. PMID: 26027859, DOI: 10.1007/s00277-015-2406-z.
- Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery.Siddon AJ, Tormey CA. Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery. Laboratory Medicine 2016, 47: e35-7. PMID: 27378481, PMCID: PMC4985779, DOI: 10.1093/labmed/lmw037.
- Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice.Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood 2016, 128: 3159-3168. PMID: 27688803, PMCID: PMC5201095, DOI: 10.1182/blood-2016-06-724732.
- Use of application containers and workflows for genomic data analysis.Schulz WL, Durant TJ, Siddon AJ, Torres R. Use of application containers and workflows for genomic data analysis. Journal Of Pathology Informatics 2016, 7: 53. PMID: 28163975, PMCID: PMC5248400, DOI: 10.4103/2153-3539.197197.
- R634W KIT Mutation in an Adult With Systemic Mastocytosis.Astle JM, Rose MG, Racke FK, Tormey CA, Siddon AJ. R634W KIT Mutation in an Adult With Systemic Mastocytosis. Laboratory Medicine 2017, 48: 253-257. PMID: 28520972, DOI: 10.1093/labmed/lmx026.
- Discordance Between Functional Screening and Genetic Confirmatory Diagnostic Tests: A Retrospective Analysis of Activated Protein C Resistance and Factor 5 Leiden Testing Over a 5-Year Period.Baraban E, Siddon A, Tormey C. Discordance Between Functional Screening and Genetic Confirmatory Diagnostic Tests: A Retrospective Analysis of Activated Protein C Resistance and Factor 5 Leiden Testing Over a 5-Year Period. American Journal Of Clinical Pathology 2017 PMID: 28339870, DOI: 10.1093/ajcp/aqw191.026.
- Morphology and flow cytometry of atypical basophils.Tormey CA, Siddon AJ. Morphology and flow cytometry of atypical basophils. Blood 2018, 132: 552. PMID: 30072417, DOI: 10.1182/blood-2018-05-850073.
- Delayed haemolytic and serologic transfusion reactions: pathophysiology, treatment and prevention.Siddon AJ, Kenney BC, Hendrickson JE, Tormey CA. Delayed haemolytic and serologic transfusion reactions: pathophysiology, treatment and prevention. Current Opinion In Hematology 2018, 25: 459-467. PMID: 30124474, DOI: 10.1097/MOH.0000000000000462.
- Be careful of the masquerades: differentiating secondary myelodysplasia from myelodysplastic syndromes in clinical practice.Shallis RM, Xu ML, Podoltsev NA, Curtis SA, Considine BT, Khanna SR, Siddon AJ, Zeidan AM. Be careful of the masquerades: differentiating secondary myelodysplasia from myelodysplastic syndromes in clinical practice. Annals Of Hematology 2018, 97: 2333-2343. PMID: 30109425, DOI: 10.1007/s00277-018-3474-7.
- Visualization of bacterial contamination in an apheresis platelet unit.Siddon AJ, Snyder EL, Tormey CA. Visualization of bacterial contamination in an apheresis platelet unit. Journal Of Clinical Apheresis 2018, 33: 671-672. PMID: 30242893, DOI: 10.1002/jca.21649.
- Modified approach to fibrinogen replacement in the setting of dysfibrinogenaemia.Chandler JB, Siddon AJ, Bahel P, Torres R, Rinder HM, Tormey CA. Modified approach to fibrinogen replacement in the setting of dysfibrinogenaemia. Journal Of Clinical Pathology 2019, 72: 177-180. PMID: 30463936, DOI: 10.1136/jclinpath-2018-205438.
- The chemical and laboratory investigation of hemolysis.Siddon AJ, Tormey CA. The chemical and laboratory investigation of hemolysis. Advances In Clinical Chemistry 2019, 89: 215-258. PMID: 30797470, DOI: 10.1016/bs.acc.2018.12.006.
- Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease.Balbuena-Merle R, Curtis SA, Devine L, Gibb DR, Karafin MS, Luckey CJ, Tormey CA, Siddon AJ, Roberts JD, Hendrickson JE. Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease. Transfusion 2019, 59: 3219-3227. PMID: 31355970, PMCID: PMC7075520, DOI: 10.1111/trf.15463.
- Acute myeloid leukemia presenting as bilateral adrenal hemorrhage.Mendoza H, Podoltsev NA, Siddon AJ, Gnanapandithan K. Acute myeloid leukemia presenting as bilateral adrenal hemorrhage. Annals Of Hematology 2019, 98: 2421-2423. PMID: 31446457, DOI: 10.1007/s00277-019-03788-7.
- DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma.Wang M, Kibbi N, Ring N, Siddon A, Foss F, Totonchy M. DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma. BMJ Case Reports 2019, 12 PMID: 31570354, PMCID: PMC6768350, DOI: 10.1136/bcr-2019-230641.
- Molecular and Cytogenetic Education in Hematopathology Fellowship.Soma LA, Kovach AE, Siddon AJ, Beck R, Gibson SE, Swerdlow SH, Kim AS, Wu D, Jones D, Cook JR, Prakash S, Rosado F, Crane G, Bradley K, Weinberg OK, Sargent RL. Molecular and Cytogenetic Education in Hematopathology Fellowship. American Journal Of Clinical Pathology 2019, 152: 438-445. PMID: 31141139, DOI: 10.1093/ajcp/aqz048.
- Investigation of increased platelet alloimmunization screening in the era of pathogen-reduced platelets treated with psoralen/UV light.Hendrickson JE, Mendoza H, Ross R, Siddon AJ, Gowda L, Hauser RG, Schulz WL, Tormey CA. Investigation of increased platelet alloimmunization screening in the era of pathogen-reduced platelets treated with psoralen/UV light. Transfusion 2020, 60: 650-651. PMID: 32128834, DOI: 10.1111/trf.15691.
- Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status.Balbuena-Merle R, Santhanakrishnan M, Devine L, Gibb DR, Tormey CA, Siddon AJ, Curtis SA, Gallagher PG, Weinstein JS, Hendrickson JE. Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status. Transfusion And Apheresis Science : Official Journal Of The World Apheresis Association : Official Journal Of The European Society For Haemapheresis 2020, 59: 102778. PMID: 32439490, PMCID: PMC7483805, DOI: 10.1016/j.transci.2020.102778.
- Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival.Schulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.
- How I Diagnose.Siddon AJ, Czader M. How I Diagnose. American Journal Of Clinical Pathology 2020, 154: 4. PMID: 32458973, DOI: 10.1093/ajcp/aqaa034.
- How I Diagnose Low-Grade Myelodysplastic Syndromes.Siddon AJ, Hasserjian RP. How I Diagnose Low-Grade Myelodysplastic Syndromes. American Journal Of Clinical Pathology 2020, 154: 5-14. PMID: 32458977, DOI: 10.1093/ajcp/aqaa046.
- Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman.Mainardi AS, Siddon AJ, Bader AS, Hilbert J. Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman. Chest 2020, 158: e327-e334. PMID: 33280778, DOI: 10.1016/j.chest.2020.07.009.
- A case of acute myeloid leukemia with unusual germline CEBPA mutation: lessons learned about mutation detection, location, and penetrance.Mendoza H, Chen PH, Pine AB, Siddon AJ, Bale AE, Gowda L, Killie A, Richards J, Varin-Tremblay C, Kloss R, Podoltsev NA. A case of acute myeloid leukemia with unusual germline CEBPA mutation: lessons learned about mutation detection, location, and penetrance. Leukemia & Lymphoma 2021, 62: 1251-1254. PMID: 33345654, DOI: 10.1080/10428194.2020.1861276.
- Evaluation of Positive B- and T-Cell Gene Rearrangement Studies in Patients With Negative Morphology, Flow Cytometry, and Immunohistochemistry.Mendoza H, Tormey CA, Siddon AJ. Evaluation of Positive B- and T-Cell Gene Rearrangement Studies in Patients With Negative Morphology, Flow Cytometry, and Immunohistochemistry. Archives Of Pathology & Laboratory Medicine 2021, 145: 227-230. PMID: 32886749, DOI: 10.5858/arpa.2019-0663-OA.
- Monocytic Acute Myeloid Leukemias with KM2TA Translocations to Chromosome 17q that May Clinically Mimic Acute Promyelocytic Leukemia.Balbuena-Merle RI, Tormey CA, DiAdamo A, Rinder HM, Siddon AJ. Monocytic Acute Myeloid Leukemias with KM2TA Translocations to Chromosome 17q that May Clinically Mimic Acute Promyelocytic Leukemia. Laboratory Medicine 2021, 52: 290-296. PMID: 32984885, DOI: 10.1093/labmed/lmaa078.
- Factor V activity in apheresis platelets: Implications for management of FV deficiency.Gupta GK, Hendrickson JE, Bahel P, Siddon AJ, Rinder HM, Tormey CA. Factor V activity in apheresis platelets: Implications for management of FV deficiency. Transfusion 2021, 61: 405-409. PMID: 33166428, DOI: 10.1111/trf.16179.
- A complex karyotype and a genetic mutation in acute myeloid leukaemia.Bewersdorf JP, Siddon A, DiAdamo A, Zeidan AM. A complex karyotype and a genetic mutation in acute myeloid leukaemia. Lancet 2021, 396: 2018. PMID: 33341145, DOI: 10.1016/S0140-6736(20)32543-5.
- The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders.Mendoza H, Tormey CA, Rinder HM, Howe JG, Siddon AJ. The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders. Pathology 2021, 53: 157-165. PMID: 33358756, DOI: 10.1016/j.pathol.2020.09.024.
- The Development and Implementation of a Novel Electronic Consult System by a Laboratory Medicine Service: Experience From the First 2 Years of Use.Stendahl K, Siddon AJ, Peaper DR, Hauser RG, Campbell S, Tormey CA. The Development and Implementation of a Novel Electronic Consult System by a Laboratory Medicine Service: Experience From the First 2 Years of Use. Archives Of Pathology & Laboratory Medicine 2021, 145: 75-81. PMID: 33367659, DOI: 10.5858/arpa.2019-0267-OA.
- Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis.Shallis RM, Siddon AJ, Zeidan AM. Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis. Current Hematologic Malignancy Reports 2021, 16: 276-285. PMID: 33890194, DOI: 10.1007/s11899-021-00632-6.
- Laboratory evaluation and prognostication among adults and children with CEBPA-mutant acute myeloid leukemia.Mendoza H, Podoltsev NA, Siddon AJ. Laboratory evaluation and prognostication among adults and children with CEBPA-mutant acute myeloid leukemia. International Journal Of Laboratory Hematology 2021, 43 Suppl 1: 86-95. PMID: 34288448, DOI: 10.1111/ijlh.13517.
- The Lab as a Driver of Quality in the Preanalytical Realm: The Case of Technologist-Assisted Bone Marrow Biopsies.Siddon AJ, Kroft SH. The Lab as a Driver of Quality in the Preanalytical Realm: The Case of Technologist-Assisted Bone Marrow Biopsies. American Journal Of Clinical Pathology 2022, 157: 480-481. PMID: 34788363, DOI: 10.1093/ajcp/aqab180.
- Concurrent COVID-19 and babesiosis in an older, splenectomized patient.Jacobs JW, Siddon AJ. Concurrent COVID-19 and babesiosis in an older, splenectomized patient. Blood 2021, 138: 2154. PMID: 34821934, PMCID: PMC8614064, DOI: 10.1182/blood.2021013947.
- Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing.Easwar A, Siddon AJ. Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing. Life (Basel, Switzerland) 2021, 11 PMID: 34833034, PMCID: PMC8625510, DOI: 10.3390/life11111158.
- CD5-positive, CD10-positive large B-cell lymphoma with t(14;18) mimicking acute leukemia.Gisriel SD, Jacobs JW, Siddon AJ. CD5-positive, CD10-positive large B-cell lymphoma with t(14;18) mimicking acute leukemia. International Journal Of Laboratory Hematology 2022, 44: 698-699. PMID: 35166437, DOI: 10.1111/ijlh.13812.
- TP53 mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML.Weinberg OK, Siddon AJ, Madanat YF, Gagan J, Arber DA, Dal Cin P, Narayanan D, Ouseph MM, Kurzer JH, Hasserjian RP. TP53 mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML. Blood Advances 2022, 6: 2847-2853. PMID: 35073573, PMCID: PMC9092405, DOI: 10.1182/bloodadvances.2021006239.
- Automated analysers underestimate atypical basophil count in myeloid neoplasms.Shah HP, Tormey CA, Siddon AJ. Automated analysers underestimate atypical basophil count in myeloid neoplasms. International Journal Of Laboratory Hematology 2022 PMID: 35609868, DOI: 10.1111/ijlh.13882.
- Behind the scenes with basophils: an emerging therapeutic target.Shah H, Eisenbarth S, Tormey CA, Siddon AJ. Behind the scenes with basophils: an emerging therapeutic target. Immunotherapy Advances 2021, 1: ltab008. PMID: 35919744, PMCID: PMC9327101, DOI: 10.1093/immadv/ltab008.