Albert Sinusas, MD
Research & Publications
Biography
News
Research Summary
My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post–infarction remodeling. This translational research employs the 3–D modalities of SPECT, PET, echocardiography and MR imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial ischemia and infarction, and peripheral arterial disease. My laboratory is currently focused on targeted molecular imaging, developing non–invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post–infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high–resolution and real–time 3D ultrasound imaging, hybrid SPECT–CT and PET–CT imaging, cardiac MR imaging, and fluorescent imaging systems.
Specialized Terms: Advanced cardiovascular and molecular imaging
Coauthors
Research Interests
Cardiology; Cardiovascular System; Echocardiography; Magnetic Resonance Imaging; Tomography, Emission-Computed, Single-Photon; Positron-Emission Tomography; Myocardial Perfusion Imaging; Translational Medical Research
Selected Publications
- Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients.Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC. Cardiovascular Imaging 2020, 13: 109-120. PMID: 30343093, PMCID: PMC6461525, DOI: 10.1016/j.jcmg.2018.08.025.
- Molecular Imaging of the Heart.Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ. Molecular Imaging of the Heart. Comprehensive Physiology 2019, 9: 477-533. PMID: 30873600, DOI: 10.1002/cphy.c180007.
- Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis.Parajuli N, Lu A, Ta K, Stendahl J, Boutagy N, Alkhalil I, Eberle M, Jeng GS, Zontak M, O'Donnell M, Sinusas AJ, Duncan JS. Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis. Medical Image Analysis 2019, 55: 116-135. PMID: 31055125, PMCID: PMC6939679, DOI: 10.1016/j.media.2019.04.007.
- Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9-Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography.Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ. Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9-Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. Circulation. Cardiovascular Imaging 2019, 12: e009063. PMID: 31296047, PMCID: PMC6629470, DOI: 10.1161/CIRCIMAGING.119.009063.
- Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling.Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation. Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/CIRCIMAGING.119.009055.
- In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents.Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ. In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents. JACC. Basic To Translational Science 2018, 3: 378-390. PMID: 30062224, PMCID: PMC6058999, DOI: 10.1016/j.jacbts.2018.02.003.
- Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease.Stacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ. Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease. Circulation. Cardiovascular Imaging 2014, 7: 92-9. PMID: 24170237, PMCID: PMC3929970, DOI: 10.1161/CIRCIMAGING.113.000884.
- Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation.Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2014, 55: 1445-51. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.
- Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction.Sahul ZH, Mukherjee R, Song J, McAteer J, Stroud RE, Dione DP, Staib L, Papademetris X, Dobrucki LW, Duncan JS, Spinale FG, Sinusas AJ. Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction. Circulation. Cardiovascular Imaging 2011, 4: 381-91. PMID: 21505092, PMCID: PMC3140564, DOI: 10.1161/CIRCIMAGING.110.961854.
Clinical Trials
Conditions | Study Title |
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Diseases of the Musculoskeletal System | Healthy Volunteers Needed for Hand and Heart Imaging Study |