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Albert Sinusas, MD

Professor of Medicine (Cardiology); Chairman, Radioactive Drug Research Committee (RDRC), Internal Med/Cardiology; Director, Animal Research Laboratories, Internal Med/Cardiolgoy; Chairman, Yale Radioactive Safety Committee (RSC), Internal Med/Cardiology; Chairman, Yale Radioactive Investigation Drug Committee (RIDC), Internal Med/Cardiology; Board of Directors, Intersocietal Accreditation Commission (IAC) -Nuclear/PET, Internal Med/Cardiology; Director, Yale Translational Research Imaging Center (Y-TRIC), Internal Med/Cardiology; Director, Advanced Cardiovascular Imaging, Internal Med/Cardiology

Contact Information

Albert Sinusas, MD

Mailing Address

  • Internal Medicine

    PO Box 208017, 789 Howard Avenue

    New Haven, CT 06520-8017

    United States

Research Summary

My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post–infarction remodeling. This translational research employs the 3–D modalities of SPECT, PET, echocardiography and MR imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial ischemia and infarction, and peripheral arterial disease. My laboratory is currently focused on targeted molecular imaging, developing non–invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post–infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high–resolution and real–time 3D ultrasound imaging, hybrid SPECT–CT and PET–CT imaging, cardiac MR imaging, and fluorescent imaging systems.

Specialized Terms: Advanced cardiovascular and molecular imaging

Coauthors

Research Interests

Cardiology; Cardiovascular System; Echocardiography; Magnetic Resonance Imaging; Tomography, Emission-Computed, Single-Photon; Positron-Emission Tomography; Myocardial Perfusion Imaging; Translational Medical Research

Selected Publications

Clinical Trials