Ajay Manhapra, MBBS
Research & Publications
Biography
Coauthors
Selected Publications
- Is psychiatric diagnostic remission associated with reduced prevalence of moderate to severe pain interference and improved functioning among adults with lifetime psychiatric disorders?Manhapra A, Zhou B, Rhee T, Rosenheck R. Is psychiatric diagnostic remission associated with reduced prevalence of moderate to severe pain interference and improved functioning among adults with lifetime psychiatric disorders? Journal Of Affective Disorders 2023, 344: 585-591. PMID: 37863364, DOI: 10.1016/j.jad.2023.10.094.
- Monotonic Association of Increasing Past-Year Substance Use Disorder across a Four-Level Trauma Post-Traumatic Stress Disorder (PTSD) Hierarchy in a Nationwide SampleJegede O, Manhapra A, Zhou B, Rhee T, Rosenheck R. Monotonic Association of Increasing Past-Year Substance Use Disorder across a Four-Level Trauma Post-Traumatic Stress Disorder (PTSD) Hierarchy in a Nationwide Sample. Journal Of Dual Diagnosis 2023, 19: 231-239. PMID: 37796996, DOI: 10.1080/15504263.2023.2260339.
- Buprenorphine use and courses of care for opioid use disorder treatment within the Veterans Health AdministrationGordon A, Saxon A, Kertesz S, Wyse J, Manhapra A, Lin L, Chen W, Hansen J, Pinnell D, Huynh T, Baylis J, Cunningham F, Ghitza U, Bart G, Yu H, Sauer B. Buprenorphine use and courses of care for opioid use disorder treatment within the Veterans Health Administration. Drug And Alcohol Dependence 2023, 248: 109902. PMID: 37196572, PMCID: PMC10875624, DOI: 10.1016/j.drugalcdep.2023.109902.
- Pain Management in Older Adults Before and During the First Year of COVID-19 Pandemic: Prevalence, Trends, and CorrelatesManhapra A, Fortinsky R, Berg K, Ross J, Rhee T. Pain Management in Older Adults Before and During the First Year of COVID-19 Pandemic: Prevalence, Trends, and Correlates. The Journals Of Gerontology Series A 2023, 78: 1627-1640. PMID: 37096328, PMCID: PMC10460550, DOI: 10.1093/gerona/glad115.
- Rethinking clinically significant pain: a marker of recovery rather than a warning of injuryManhapra A. Rethinking clinically significant pain: a marker of recovery rather than a warning of injury. Pain 2023, 164: e174-e174. PMID: 36779559, DOI: 10.1097/j.pain.0000000000002800.
- Complex Persistent Opioid Dependence—an Opioid-induced Chronic Pain SyndromeManhapra A. Complex Persistent Opioid Dependence—an Opioid-induced Chronic Pain Syndrome. Current Treatment Options In Oncology 2022, 23: 921-935. PMID: 35435616, DOI: 10.1007/s11864-022-00985-x.
- Persistence of significant pain interference following substance use disorder remission: Negative association with psychosocial and physical recoveryManhapra A, Stefanovics EA, Rhee TG, Rosenheck RA. Persistence of significant pain interference following substance use disorder remission: Negative association with psychosocial and physical recovery. Drug And Alcohol Dependence 2022, 232: 109339. PMID: 35121202, DOI: 10.1016/j.drugalcdep.2022.109339.
- Who Uses Veterans Mental Health Services?Manhapra A, Stefanovics EA, Rhee TG, Rosenheck RA. Who Uses Veterans Mental Health Services? The Journal Of Nervous And Mental Disease 2021, 209: 702-709. PMID: 33993183, DOI: 10.1097/nmd.0000000000001369.
- Twelve-Month Retention in Opioid Agonist Treatment for Opioid Use Disorder Among Patients With and Without HIVWyse JJ, McGinnis KA, Edelman EJ, Gordon AJ, Manhapra A, Fiellin DA, Moore BA, Korthuis PT, Kennedy AJ, Oldfield BJ, Gaither JR, Gordon KS, Skanderson M, Barry DT, Bryant K, Crystal S, Justice AC, Kraemer KL. Twelve-Month Retention in Opioid Agonist Treatment for Opioid Use Disorder Among Patients With and Without HIV. AIDS And Behavior 2021, 26: 975-985. PMID: 34495424, PMCID: PMC8840957, DOI: 10.1007/s10461-021-03452-0.
- The association of opioid use disorder and homelessness nationally in the veterans health administrationManhapra A, Stefanovics E, Rosenheck R. The association of opioid use disorder and homelessness nationally in the veterans health administration. Drug And Alcohol Dependence 2021, 223: 108714. PMID: 33865213, DOI: 10.1016/j.drugalcdep.2021.108714.
- Assessment of Common Comorbidity Phenotypes Among Older Adults With Knee Osteoarthritis to Inform Integrated Care ModelsLentz T, Hellkamp A, Bhavsar N, Goode A, Manhapra A, George S. Assessment of Common Comorbidity Phenotypes Among Older Adults With Knee Osteoarthritis to Inform Integrated Care Models. Mayo Clinic Proceedings Innovations Quality & Outcomes 2021, 5: 253-264. PMID: 33997625, PMCID: PMC8105527, DOI: 10.1016/j.mayocpiqo.2020.09.011.
- Association of symptom severity, pain and other behavioral and medical comorbidities with diverse measures of functioning among adults with post-traumatic stress disorderManhapra A, Stefanovics EA, Rhee TG, Rosenheck RA. Association of symptom severity, pain and other behavioral and medical comorbidities with diverse measures of functioning among adults with post-traumatic stress disorder. Journal Of Psychiatric Research 2020, 134: 113-120. PMID: 33383494, DOI: 10.1016/j.jpsychires.2020.12.063.
- Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy ChangesManhapra A, Sullivan MD, Ballantyne JC, MacLean RR, Becker WC. Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes. Journal Of General Internal Medicine 2020, 35: 964-971. PMID: 33159241, PMCID: PMC7728942, DOI: 10.1007/s11606-020-06251-w.
- Ensuring Patient Protections When Tapering Opioids: Consensus Panel RecommendationsCovington E, Argoff C, Ballantyne J, Cowan P, Gazelka H, Hooten W, Kertesz S, Manhapra A, Murphy J, Stanos S, Sullivan M. Ensuring Patient Protections When Tapering Opioids: Consensus Panel Recommendations. Mayo Clinic Proceedings 2020, 95: 2155-2171. PMID: 33012347, DOI: 10.1016/j.mayocp.2020.04.025.
- All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factorsGordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.
- Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluationOliva E, Bowe T, Manhapra A, Kertesz S, Hah J, Henderson P, Robinson A, Paik M, Sandbrink F, Gordon A, Trafton J. Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation. The BMJ 2020, 368: m283. PMID: 32131996, PMCID: PMC7249243, DOI: 10.1136/bmj.m283.
- Nonconsensual Dose Reduction Mandates are Not Justified Clinically or Ethically: An AnalysisKertesz S, Manhapra A, Gordon A. Nonconsensual Dose Reduction Mandates are Not Justified Clinically or Ethically: An Analysis. The Journal Of Law, Medicine & Ethics 2020, 48: 259-267. PMID: 32631183, PMCID: PMC7938366, DOI: 10.1177/1073110520935337.
- High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans.Banerjee G, Edelman EJ, Barry DT, Crystal S, Gordon KS, Gordon AJ, Gaither JR, Green TC, Kerns RD, Manhapra A, Moore BA, Fiellin DA, Marshall BDL. High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans. Pain 2019, 160: 2126-2135. PMID: 31145217, PMCID: PMC6699915, DOI: 10.1097/j.pain.0000000000001606.
- Prescribing, Prescription Monitoring, and Health PolicyGordon A, Cochran G, Smid M, Manhapra A, Kertesz S. Prescribing, Prescription Monitoring, and Health Policy. 2019, 223-238. DOI: 10.1007/978-3-030-16257-3_11.
- Systematic Review of Pain Severity and Opioid Craving in Chronic Pain and Opioid Use Disorder.MacLean RR, Spinola S, Manhapra A, Sofuoglu M. Systematic Review of Pain Severity and Opioid Craving in Chronic Pain and Opioid Use Disorder. Pain Medicine 2019, 21: e146-e163. PMID: 32034413, DOI: 10.1093/pm/pnz228.
- Multimodal Treatment Options, Including Rotating to Buprenorphine, Within a Multidisciplinary Pain Clinic for Patients on Risky Opioid Regimens: A Quality Improvement StudyOldfield BJ, Edens EL, Agnoli A, Bone CW, Cervone DJ, Edmond SN, Manhapra A, Sellinger JJ, Becker WC. Multimodal Treatment Options, Including Rotating to Buprenorphine, Within a Multidisciplinary Pain Clinic for Patients on Risky Opioid Regimens: A Quality Improvement Study. Pain Medicine 2018, 19: s38-s45. PMID: 30203007, DOI: 10.1093/pm/pny086.
- The Conundrum of Opioid Tapering in Long-Term Opioid Therapy for Chronic Pain: A CommentaryManhapra A, Arias A, Ballantyne J. The Conundrum of Opioid Tapering in Long-Term Opioid Therapy for Chronic Pain: A Commentary. Substance Abuse 2018, 39: 152-161. PMID: 28929914, PMCID: PMC6129223, DOI: 10.1080/08897077.2017.1381663.
- Three‐year retention in buprenorphine treatment for opioid use disorder nationally in the Veterans Health AdministrationManhapra A, Petrakis I, Rosenheck R. Three‐year retention in buprenorphine treatment for opioid use disorder nationally in the Veterans Health Administration. American Journal On Addictions 2017, 26: 572-580. PMID: 28472543, DOI: 10.1111/ajad.12553.
- Opioid substitution treatment is linked to reduced risk of death in opioid use disorderManhapra A, Rosenheck R, Fiellin DA. Opioid substitution treatment is linked to reduced risk of death in opioid use disorder. The BMJ 2017, 357: j1947. PMID: 28446438, PMCID: PMC5412085, DOI: 10.1136/bmj.j1947.
- Evaluation of an Integrated, Multidisciplinary Program to Address Unsafe Use of Opioids Prescribed for PainBecker WC, Edmond SN, Cervone DJ, Manhapra A, Sellinger JJ, Moore BA, Edens EL. Evaluation of an Integrated, Multidisciplinary Program to Address Unsafe Use of Opioids Prescribed for Pain. Pain Medicine 2017, 19: 1419-1424. PMID: 28371816, DOI: 10.1093/pm/pnx041.
- “The devil I know is better than the devil I don’t know”: Enrollment in a pilot trial of opioid dose escalation vs. buprenorphine/naloxone for painManhapra A, Fiellin D, Becker W. “The devil I know is better than the devil I don’t know”: Enrollment in a pilot trial of opioid dose escalation vs. buprenorphine/naloxone for pain. Drug And Alcohol Dependence 2017, 171: e128. DOI: 10.1016/j.drugalcdep.2016.08.356.
- Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control studyVemparala K, Roy A, Bahl V, Prabhakaran D, Nath N, Sinha S, Nandi P, Pandey R, Reddy K, Manhapra A, Lakshmy R. Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study. BMC Cardiovascular Disorders 2013, 13: 104. PMID: 24245738, PMCID: PMC3871012, DOI: 10.1186/1471-2261-13-104.
- Differences in the prevalence of metabolic syndrome in urban and rural India: a problem of urbanizationPrabhakaran D, Chaturvedi V, Shah P, Manhapra A, Jeemon P, Shah B, Srinath Reddy K. Differences in the prevalence of metabolic syndrome in urban and rural India: a problem of urbanization. Chronic Illness 2007, 3: 8-19. PMID: 18072694, DOI: 10.1177/1742395307079197.
- Sex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM. Sex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002. New England Journal Of Medicine 2005, 353: 671-682. PMID: 16107620, PMCID: PMC2805130, DOI: 10.1056/nejmsa032214.
- Cardiovascular risk factor prevalence among men in a large industry of northern India.Prabhakaran D, Shah P, Chaturvedi V, Ramakrishnan L, Manhapra A, Reddy K. Cardiovascular risk factor prevalence among men in a large industry of northern India. The National Medical Journal Of India 2005, 18: 59-65. PMID: 15981439.
- Relation of age and race with hospital death after acute myocardial infarctionManhapra A, Canto J, Vaccarino V, Parsons L, Kiefe C, Barron H, Rogers W, Weaver W, Borzak S. Relation of age and race with hospital death after acute myocardial infarction. American Heart Journal 2004, 148: 92-98. PMID: 15215797, DOI: 10.1016/j.ahj.2004.02.010.
- 1135-67 Time trends in the treatment of women and men with acute myocardial infarction in the United StatesVaccarino V, Frederick P, Barron H, Abramson J, Manhapra A, Mallik S, Wenger N. 1135-67 Time trends in the treatment of women and men with acute myocardial infarction in the United States. Journal Of The American College Of Cardiology 2004, 43: a412. DOI: 10.1016/s0735-1097(04)91740-8.
- Why is chronic kidney disease the “spoiler” for cardiovascular outcomes: an alternate take from a generalistManhapra A. Why is chronic kidney disease the “spoiler” for cardiovascular outcomes: an alternate take from a generalist. Journal Of The American College Of Cardiology 2004, 43: 924. PMID: 14998637, DOI: 10.1016/j.jacc.2003.12.017.
- Underutilization of reperfusion therapy in eligible African Americans with acute myocardial infarction: Role of presentation and evaluation characteristicsManhapra A, Canto J, Barron H, Malmgren J, Taylor H, Rogers W, Weaver W, Every N, Borzak S. Underutilization of reperfusion therapy in eligible African Americans with acute myocardial infarction: Role of presentation and evaluation characteristics. American Heart Journal 2001, 142: 604-610. PMID: 11579349, DOI: 10.1067/mhj.2001.118464.
- Systemic Inflammation: The Central Factor in Pathogenesis of Unstable AnginaManhapra A, Gupta R, Kasliwal R. Systemic Inflammation: The Central Factor in Pathogenesis of Unstable Angina. Circulation 2001, 103: e91-e91. PMID: 11319212, DOI: 10.1161/01.cir.103.16.e91.
- Ethnicity is an independent risk factor for CVDReddy K, Manhapra A. Ethnicity is an independent risk factor for CVD. Evidence-based Cardiovascular Medicine 2000, 4: 95-96. DOI: 10.1054/ebcm.2000.0341.
- Treatment possibilities for unstable anginaManhapra A, Borzak S. Treatment possibilities for unstable angina. The BMJ 2000, 321: 1269. PMID: 11082091, PMCID: PMC1119013, DOI: 10.1136/bmj.321.7271.1269.
- Electrocardiographic presentation of blacks with first myocardial infarction does not explain race differences in thrombolysis administrationManhapra A, Khaja F, Syed M, Rybicki B, Wulbrecht N, Alam M, Sabbah H, Goldstein S, Borzak S. Electrocardiographic presentation of blacks with first myocardial infarction does not explain race differences in thrombolysis administration. American Heart Journal 2000, 140: 200-205. PMID: 10925330, DOI: 10.1067/mhj.2000.107173.