Adam Mecca, MD, PhD
Assistant Professor of Psychiatry; Associate Director, Alzheimer's Disease Research Unit; Faculty, Alzheimer's Disease Research Center (ADRC)
Research & Publications
Biography
News
Coauthors
Selected Publications
- Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort.Naganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca AP, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2021, 62: 418-421. PMID: 32646875, PMCID: PMC8049341, DOI: 10.2967/jnumed.120.243949.
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association.Mecca AP, van Dyck CH. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Alzheimer's & Dementia : The Journal Of The Alzheimer's Association 2021, 17: 316-317. PMID: 33047474, PMCID: PMC7962853, DOI: 10.1002/alz.12190.
- Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J.O'Dell RS, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J. Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
- Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O'Dell RS, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678X211004312.
- Amyloid-Associated Depression-or Not?van Dyck CH, O'Dell RS, Mecca AP. Amyloid-Associated Depression-or Not? Biological Psychiatry 2021, 89: 737-738. PMID: 33766236, PMCID: PMC8396710, DOI: 10.1016/j.biopsych.2021.02.008.
- Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Human Molecular Genetics 2021, 30: 1360-1370. PMID: 33831179, PMCID: PMC8255129, DOI: 10.1093/hmg/ddab102.
- Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis.Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D'Souza DC, Esterlis I, Worhunsky PD, Carson RE. Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis. NeuroImage 2021, 237: 118167. PMID: 34000404, PMCID: PMC8452380, DOI: 10.1016/j.neuroimage.2021.118167.
- Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET.Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET. NeuroImage 2021, 238: 118217. PMID: 34052464, PMCID: PMC8378132, DOI: 10.1016/j.neuroimage.2021.118217.
- Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease.Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
- Generation of synthetic PET images of synaptic density and amyloid from 18 F-FDG images using deep learning.Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai YJ, Naganawa M, Ma T, Liu Y, Chen MK, Mecca AP, O'Dell RS, van Dyck CH, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18 F-FDG images using deep learning. Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
- Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance.Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.
- Statin Use and Risk of Cognitive Decline in the ADNI Cohort.Kemp EC, Ebner MK, Ramanan S, Godek TA, Pugh EA, Bartlett HH, McDonald JW, Mecca MC, van Dyck CH, Mecca AP. Statin Use and Risk of Cognitive Decline in the ADNI Cohort. The American Journal Of Geriatric Psychiatry : Official Journal Of The American Association For Geriatric Psychiatry 2020, 28: 507-517. PMID: 31806426, PMCID: PMC7170771, DOI: 10.1016/j.jagp.2019.11.003.
- PET imaging of mGluR5 in Alzheimer's disease.Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer's disease. Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
- Amyloid: From Starch to Finish.Krystal HL, Ross DA, Mecca AP. Amyloid: From Starch to Finish. Biological Psychiatry 2020, 87: e23-e24. PMID: 32299582, PMCID: PMC7449531, DOI: 10.1016/j.biopsych.2020.02.1182.
- In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET.Mecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Wyk BCV, Varma P, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET. Alzheimer's & Dementia : The Journal Of The Alzheimer's Association 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
- Assessing an Interprofessional Polypharmacy and Deprescribing Educational Intervention for Primary Care Post-graduate Trainees: a Quantitative and Qualitative Evaluation.Mecca MC, Thomas JM, Niehoff KM, Hyson A, Jeffery SM, Sellinger J, Mecca AP, Van Ness PH, Fried TR, Brienza R. Assessing an Interprofessional Polypharmacy and Deprescribing Educational Intervention for Primary Care Post-graduate Trainees: a Quantitative and Qualitative Evaluation. Journal Of General Internal Medicine 2019, 34: 1220-1227. PMID: 30972554, PMCID: PMC6614292, DOI: 10.1007/s11606-019-04932-9.
- Development and Validation of a Polypharmacy Knowledge Assessment Instrument.Thomas JM, Mecca MC, Niehoff KM, Mecca AP, Van Ness PH, Brienza R, Hyson A, Jeffery S. Development and Validation of a Polypharmacy Knowledge Assessment Instrument. American Journal Of Pharmaceutical Education 2019, 83: 6435. PMID: 31333246, PMCID: PMC6630871, DOI: 10.5688/ajpe6435.
- AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems.Mecca AP. AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems. Progress In Molecular Biology And Translational Science 2019, 165: 139-165. PMID: 31481161, DOI: 10.1016/bs.pmbts.2019.04.003.
- Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease. Neurobiology Of Aging 2018, 61: 207-214. PMID: 29111487, PMCID: PMC5722236, DOI: 10.1016/j.neurobiolaging.2017.09.027.
- Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.
- Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
- Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort.Mecca AP, Michalak HR, McDonald JW, Kemp EC, Pugh EA, Becker ML, Mecca MC, van Dyck CH. Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort. Dementia And Geriatric Cognitive Disorders 2018, 45: 232-242. PMID: 29886490, PMCID: PMC6178799, DOI: 10.1159/000488671.
- Effects of Normative Adjustments to the Montreal Cognitive Assessment.Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES. Effects of Normative Adjustments to the Montreal Cognitive Assessment. The American Journal Of Geriatric Psychiatry : Official Journal Of The American Association For Geriatric Psychiatry 2018, 26: 1258-1267. PMID: 30314940, PMCID: PMC6779033, DOI: 10.1016/j.jagp.2018.09.009.
- Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy.Regenhardt RW, Mecca AP, Flavin SA, Boulouis G, Lauer A, Zachrison KS, Boomhower J, Patel AB, Hirsch JA, Schwamm LH, Leslie-Mazwi TM. Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy. Stroke; A Journal Of Cerebral Circulation 2018, 49: 1419-1425. PMID: 29712881, PMCID: PMC5970980, DOI: 10.1161/STROKEAHA.118.020618.
- Idiom use in a young man with schizophrenia and prominent sexual delusions.Fineberg SK, Mecca A, Lerner BA, Hills OF, Corlett PR, Viron M. Idiom use in a young man with schizophrenia and prominent sexual delusions. Harvard Review Of Psychiatry 2014, 22: 306-15. PMID: 25188734, DOI: 10.1097/HRP.0000000000000053.
- Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.Regenhardt RW, Mecca AP, Desland F, Ritucci-Chinni PF, Ludin JA, Greenstein D, Banuelos C, Bizon JL, Reinhard MK, Sumners C. Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats. Experimental Physiology 2014, 99: 442-53. PMID: 24142453, PMCID: PMC7416533, DOI: 10.1113/expphysiol.2013.075242.
- The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology 2014, 81: 134-41. PMID: 24508710, PMCID: PMC7472595, DOI: 10.1016/j.neuropharm.2014.01.044.
- Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat.Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP. Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal Of Visualized Experiments : JoVE 2013 PMID: 23438950, PMCID: PMC3601209, DOI: 10.3791/50014.
- Utilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion.Regenhardt RW, Ansari S, Azari H, Caldwell KJ, Mecca AP. Utilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion. Journal Of Visualized Experiments : JoVE 2013, e50015. PMID: 23463164, PMCID: PMC3605805, DOI: 10.3791/50015.
- Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke.Regenhardt RW, Desland F, Mecca AP, Pioquinto DJ, Afzal A, Mocco J, Sumners C. Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke. Neuropharmacology 2013, 71: 154-63. PMID: 23583926, PMCID: PMC3664115, DOI: 10.1016/j.neuropharm.2013.03.025.
- Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE. Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. Amino Acids 2011, 40: 1151-8. PMID: 20839013, PMCID: PMC8396070, DOI: 10.1007/s00726-010-0739-4.
- Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.Mecca AP, Regenhardt RW, O'Connor TE, Joseph JP, Raizada MK, Katovich MJ, Sumners C. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Experimental Physiology 2011, 96: 1084-96. PMID: 21685445, PMCID: PMC3210510, DOI: 10.1113/expphysiol.2011.058578.
- Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases.Ferreira AJ, Santos RA, Bradford CN, Mecca AP, Sumners C, Katovich MJ, Raizada MK. Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases. Hypertension 2010, 55: 207-13. PMID: 20038757, PMCID: PMC2826213, DOI: 10.1161/HYPERTENSIONAHA.109.140145.
- Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion.Mecca AP, O'Connor TE, Katovich MJ, Sumners C. Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion. Experimental Physiology 2009, 94: 937-46. PMID: 19429641, PMCID: PMC2742297, DOI: 10.1113/expphysiol.2009.047936.
- Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.Cao W, Shah HP, Glushakov AV, Mecca AP, Shi P, Sumners C, Seubert CN, Martynyuk AE. Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. British Journal Of Pharmacology 2009, 158: 2005-13. PMID: 20050189, PMCID: PMC2807662, DOI: 10.1111/j.1476-5381.2009.00498.x.
- Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7).Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). American Journal Of Physiology. Heart And Circulatory Physiology 2007, 292: H736-42. PMID: 17098828, DOI: 10.1152/ajpheart.00937.2006.
- Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension.Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. American Journal Of Physiology. Heart And Circulatory Physiology 2006, 290: H2417-23. PMID: 16415071, DOI: 10.1152/ajpheart.01170.2005.
- Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats.Mitra A, Katovich MJ, Mecca A, Rowland NE. Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats. Physiology & Behavior 2006, 89: 221-5. PMID: 16839572, DOI: 10.1016/j.physbeh.2006.06.006.
- Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats.Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Experimental Physiology 2005, 90: 783-90. PMID: 16049057, DOI: 10.1113/expphysiol.2005.031096.