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Abhijeet Gummadavelli, MD

Hospital Resident

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Abhijeet Gummadavelli, MD

Research Summary

Temporal lobe seizures are the most common form of localized epilepsy. How do focal seizures impair consciousness? We propose a “network inhibition hypothesis” in which temporal lobe seizures inhibit subcortical arousal systems, causing depressed cortical function. In support of this hypothesis, we found sleep-like changes in the cortex with intracranial EEG and SPECT during temporal lobe seizures. I am involved in translational research in animal models and in patients to reveal the fundamental mechanisms of these changes, and to test novel neuromodulatory approaches.


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Selected Publications