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Abhishek Kumar, PhD

Associate Research Scientist in Medicine (Cardiology)

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Abhishek Kumar, PhD

Coauthors

Selected Publications

  • Actin flow-dependent and -independent force transmission through integrins.Driscoll TP, Ahn SJ, Huang B, Kumar A, Schwartz MA. Actin flow-dependent and -independent force transmission through integrins. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 32413-32422. PMID: 33262280, PMCID: PMC7768777, DOI: 10.1073/pnas.2010292117.
  • MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation.Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nature Communications 2019, 10: 1695. PMID: 30979898, PMCID: PMC6461646, DOI: 10.1038/s41467-019-09636-6.
  • Filamin A mediates isotropic distribution of applied force across the actin network.Kumar A, Shutova MS, Tanaka K, Iwamoto DV, Calderwood DA, Svitkina TM, Schwartz MA. Filamin A mediates isotropic distribution of applied force across the actin network. The Journal Of Cell Biology 2019, 218: 2481-2491. PMID: 31315944, PMCID: PMC6683746, DOI: 10.1083/jcb.201901086.
  • Cell geometric control of nuclear dynamics and its implicationsNA
  • Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale.Kumar A, Anderson KL, Swift MF, Hanein D, Volkmann N, Schwartz MA. Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale. Biophysical Journal 2018, 115: 1569-1579. PMID: 30274833, PMCID: PMC6372196, DOI: 10.1016/j.bpj.2018.08.045.
  • Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. The Journal Of Experimental Medicine 2016, 213: 451-63. PMID: 26858344, PMCID: PMC4813675, DOI: 10.1084/jem.20150688.
  • Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA. Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. The Journal Of Cell Biology 2016, 213: 371-83. PMID: 27161398, PMCID: PMC4862330, DOI: 10.1083/jcb.201510012.
  • Dynamic interaction between actin and nesprin2 maintain the cell nucleus in a prestressed state.Kumar A, Shivashankar GV. Dynamic interaction between actin and nesprin2 maintain the cell nucleus in a prestressed state. Methods And Applications In Fluorescence 2016, 4: 044008. PMID: 28192301, DOI: 10.1088/2050-6120/4/4/044008.
  • The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry.Li Q, Kumar A, Makhija E, Shivashankar GV. The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry. Biomaterials 2014, 35: 961-9. PMID: 24183171, DOI: 10.1016/j.biomaterials.2013.10.037.
  • Actomyosin contractility rotates the cell nucleus.Kumar A, Maitra A, Sumit M, Ramaswamy S, Shivashankar GV. Actomyosin contractility rotates the cell nucleus. Scientific Reports 2014, 4: 3781. PMID: 24445418, PMCID: PMC3896915, DOI: 10.1038/srep03781.
  • Correlated spatio-temporal fluctuations in chromatin compaction states characterize stem cells.Talwar S, Kumar A, Rao M, Menon GI, Shivashankar GV. Correlated spatio-temporal fluctuations in chromatin compaction states characterize stem cells. Biophysical Journal 2013, 104: 553-64. PMID: 23442906, PMCID: PMC3566460, DOI: 10.1016/j.bpj.2012.12.033.
  • Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility.Jain N, Iyer KV, Kumar A, Shivashankar GV. Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 11349-54. PMID: 23798429, PMCID: PMC3710882, DOI: 10.1073/pnas.1300801110.
  • Mechanical force alters morphogenetic movements and segmental gene expression patterns during Drosophila embryogenesis.Kumar A, Shivashankar GV. Mechanical force alters morphogenetic movements and segmental gene expression patterns during Drosophila embryogenesis. PloS One 2012, 7: e33089. PMID: 22470437, PMCID: PMC3310051, DOI: 10.1371/journal.pone.0033089.
  • Prestressed nuclear organization in living cells.Mazumder A, Roopa T, Kumar A, Iyer KV, Ramdas NM, Shivashankar GV. Prestressed nuclear organization in living cells. Methods In Cell Biology 2010, 98: 221-39. PMID: 20816237, DOI: 10.1016/S0091-679X(10)98010-2.
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