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Amy Ahasic

MD, MPH, FCCP

Contact Information

Amy Ahasic, MD, MPH, FCCP

Mailing Address

  • P.O. Box 208057

    300 Cedar Street

    New Haven, CT 06520-8057

    United States

Research Summary

My research interest centers around obesity and metabolic pathways in critical illness. Because of their impact on cardiac and pulmonary function, such pathways may affect risk and prognosis in critical illness. I focus on acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and sepsis as common critical illness with systemic physiologic derangements and high morbidity and mortality. The relationship between obesity and ARDS is of particular interest. My current American Heart Association grant focuses on patient-oriented research of both phenotypic and genotypic markers relevant to metabolic pathways, including insulin-like growth factor (IGF) and adipokines, in acute lung injury.

Extensive Research Description

My research interest centers around obesity and metabolic pathways in critical illness. Because of their impact on cardiac and pulmonary function, such pathways may affect risk and prognosis in critical illness. I focus on acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and sepsis as common critical illness with systemic physiologic derangements and high morbidity and mortality. The relationship between obesity and ARDS is of particular interest. My current American Heart Association grant focuses on patient-oriented research of both phenotypic and genotypic markers relevant to metabolic pathways, including insulin-like growth factor (IGF) and adipokines, in acute lung injury.

I am also interested in the aging ICU population, and their functional and cognitive outcomes after critical illness. This extends to the cognitive-metabolic connection linking various metabolic phenomena such as obesity and insulin resistance to cognitive impairment and delirium, particularly in older adults. Delirium in the ICU is a common phenomenon for which age is a major risk factor, and its occurrence has significant impacts on morbidity and mortality.

Yale MICU Biorepository project: Principal Investigator on this initiative to collect clinical data and biologic specimens from a broad range of critically ill patients. We have enrolled approximately 700 patients to date.

Coauthors

Research Interests

Aging; Critical Care; Delirium; Epidemiology; Obesity; Occupational Medicine; Respiratory Distress Syndrome, Adult; Pulmonary Medicine; Sepsis; Environmental Medicine; Acute Lung Injury

Public Health Interests

Environmental Health; Genetics, Genomics, Epigenetics; Obesity; Occupational Health; Respiratory Disease/Infections

Selected Publications