Scott Swenson, MD, PhD
Research & Publications
Biography
Research Summary
I am investigating the role of stem and progenitor cells in the liver during normal development and in response to liver injury. The liver's remarkable capacity for regeneration after injury suggests that a better understanding of these phenomena will lead to novel cell therapy and regenerative medicine approaches to acute and chronic liver disease. Under some conditions, cells arising from the bone marrow may also contribute to liver regeneration.
The Y chromosome (pink dots) colocalizes with HNF-1 (green nuclei). Nuclei are counterstained with DAPI (blue). The recipient mouse had a homozygous targeted mutation in the Fumaryl acetoacetate hydrolase (FAH) gene, which models the human liver disease, Hereditary Tyrosinemia. Transplantation of normal bone marrow results in extensive repopulation of normal hepatocytes in the tyrosinemic liver. The presence of two or more Y chromosomes in some hepatocytes is consistent with the normal phenomenon of hepatocyte polyploidy.
Ongoing studies will address the issue of whether stable in vivo fusion of cells of hematopoietic origin, such as Kupffer cells, with injured hepatocytes always accounts for the apparent developmental "plasticity" of bone marrow-derived cells.
Coauthors
Research Interests
Hepatitis; Liver Cirrhosis; Pancreatic Diseases
Selected Publications
- Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factorsSwenson ES. Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factors. Hepatology 2011, 55: 316-318. PMID: 22190377, DOI: 10.1002/hep.24717.
- Stem cell therapeutics: potential in the treatment of inflammatory bowel diseaseSwenson E, Theise N. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clinical And Experimental Gastroenterology 2010, Volume 3: 1-10. PMID: 21694840, PMCID: PMC3108654, DOI: 10.2147/ceg.s6836.
- Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cellsMohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells. Hepatology 2009, 51: 963-973. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.
- Chimeric mice reveal clonal development of pancreatic acini, but not isletsSwenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2008, 379: 526-531. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.
- The hepatic stem cell niche: Identification by label‐retaining cell assayKuwahara R, Kofman AV, Landis CS, Swenson ES, Barendswaard E, Theise ND. The hepatic stem cell niche: Identification by label‐retaining cell assay. Hepatology 2008, 47: 1994-2002. PMID: 18454509, PMCID: PMC2847183, DOI: 10.1002/hep.22218.
- Hepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in MiceSwenson ES, Guest I, Ilic Z, Mazzeo‐Helgevold M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in Mice. Stem Cells 2008, 26: 1768-1777. PMID: 18467658, PMCID: PMC2846397, DOI: 10.1634/stemcells.2008-0148.
- Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regenerationSwenson ES, Kuwahara R, Krause DS, Theise ND. Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regeneration. Liver International 2008, 28: 308-318. PMID: 18290773, PMCID: PMC2846401, DOI: 10.1111/j.1478-3231.2007.01659.x.
- Induced pluripotent cells mimicking human embryonic stem cells.Mohamadnejad M, Swenson ES. Induced pluripotent cells mimicking human embryonic stem cells. Archives Of Iranian Medicine 2008, 11: 125-8. PMID: 18154436, DOI: 08111/aim.0026.
- Limitations of Green Fluorescent Protein as a Cell Lineage MarkerSwenson ES, Price JG, Brazelton T, Krause DS. Limitations of Green Fluorescent Protein as a Cell Lineage Marker. Stem Cells 2007, 25: 2593-2600. PMID: 17615263, DOI: 10.1634/stemcells.2007-0241.