Jean-Dominique Gallezot, PhD
Research Scientist in Radiology and Biomedical ImagingDownloadHi-Res Photo
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Radiology & Biomedical Imaging
PO Box 208042
New Haven, CT 06520-8042
United States
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Titles
Research Scientist in Radiology and Biomedical Imaging
Appointments
Radiology & Biomedical Imaging
Research ScientistPrimary
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Education & Training
- PhD
- Universite Pierre et Marie Curie, Neuroscience (2006)
- MS
- Université Pierre et Marie Curie, Neuroscience (2002)
- ME
- École Supérieure d'Électricité, Digital Telecommunications (2002)
- BS
- Ecole Polytechnique, Physics (2000)
Research
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Overview
Medical Research Interests
Brain; Data Analysis; Imaging, Three-Dimensional; Molecular Imaging; Positron-Emission Tomography; Receptors, Neurotransmitter; Whole Body Imaging
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jean-Dominique Gallezot's published research.
Publications Timeline
A big-picture view of Jean-Dominique Gallezot's research output by year.
Research Interests
Research topics Jean-Dominique Gallezot is interested in exploring.
Richard Carson, PhD
Nabeel Nabulsi, PhD
David Matuskey, MD
Mika Naganawa, PhD
Yiyun Huang, PhD
Chi Liu, PhD
126Publications
6,223Citations
Positron-Emission Tomography
Brain
Molecular Imaging
Imaging, Three-Dimensional
Whole Body Imaging
Publications
2026
Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans (P3-12.005)
Yang Y, Ibrahim W, Gravel P, pittman B, Hoye J, Sadabad F, Cool R, Zheng M, Pittenger C, Gallezot J, Carson R, Huang H, Radhakrishnan R, Matuskey D. Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans (P3-12.005). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000212778.Peer-Reviewed Original ResearchOptimization of brain PET markerless head motion correction in a large human cohort
Zeng T, Zhang J, Gallezot J, Fontaine K, Jiang W, Gravel P, Mulnix T, Naganawa M, Yang Z, Zhang X, Wang S, Sun X, Hu L, Carson R. Optimization of brain PET markerless head motion correction in a large human cohort. EJNMMI Physics 2026 PMID: 42213388, DOI: 10.1186/s40658-026-00885-1.Peer-Reviewed Original ResearchAltmetricConceptsPost-reconstruction registrationMotion correctionBrain PETHead motion correctionCentroid of distributionMarkerless motion trackingUncorrected motionSiemens mCTIntentional facial expressionsStandardized uptake valueTime activity curvesFacial expressionsIterative Closest Points registrationMotion effectsFace regionImage resolutionUpper face regionCorrectionHuman studiesPoint registrationMotion trackingHead motionMotionAutomatic processingMeasured motionOptimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J
Khattar N, Matuskey D, Gallezot J, Naganawa M, Holmes S, Sadabad F, Mayeli M, Esterlis I, van Dyck C, Mecca A, D’Souza D, Nabulsi N, Finnema S, Huang Y, Carson R, Toyonaga T. Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261441071. PMID: 41960765, PMCID: PMC13068773, DOI: 10.1177/0271678x261441071.Peer-Reviewed Original ResearchAltmetricConceptsSynaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET
Fesharaki‐Zadeh A, Cayir S, Ibrahim W, Yang Y, Gallezot J, Naganawa M, Wu Y, Toyonaga T, Sadabad F, O'Dell R, Pittman B, Nabulsi N, Strittmatter S, Carson R, Huang Y, van Dyck C, Mecca A, Matuskey D. Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET. Alzheimer's & Dementia 2026, 22: e71283. PMID: 41954197, PMCID: PMC13063251, DOI: 10.1002/alz.71283.Peer-Reviewed Original ResearchThis study investigates synaptic density imaging in behavioral variant frontotemporal dementia, showing that SV2A PET detects more pronounced synaptic loss than glucose hypometabolism using FDG PET, aiding early diagnosis and monitoring.Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction
Gravel P, Gallezot J, Fontaine K, Matuskey D, Carson R. Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction. Physics In Medicine And Biology 2026, 71: 065007. PMID: 41825140, PMCID: PMC13014069, DOI: 10.1088/1361-6560/ae520a.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsNoninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models
Hernández-Martín N, Balayeva T, Naganawa M, Asch R, Huang Y, Carson R, Gallezot J, Cai Z. Noninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models. Journal Of Nuclear Medicine 2026, 67: 796-802. PMID: 41679926, PMCID: PMC13138105, DOI: 10.2967/jnumed.125.271207.Peer-Reviewed Original ResearchThis study investigates simplified models for measuring brain synaptic density using SV2A PET scans, showing a 40-minute scan can reliably replace invasive methods, improving clinical feasibility.Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising
Liu Q, Guo X, Tsai Y, Gallezot J, Chen M, Guo L, Xie H, Panin V, Carson R, Liu C. Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3656480.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioSelf-supervised deep learning frameworkSelf-supervised learningDeep learning frameworkCycleGAN-based modelDenoising NetworkConsistency lossLesion signal-to-noise ratioDynamic PET datasetsLearning frameworkSupervised methodsU-NetMulti-center datasetDenoisingCycleGANDatasetImage qualityPET datasetsDynamic framesFitting errorClinical deploymentImagesPhysiologically meaningful measuresDynamic PET dataFrame
2025
Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism
Naples A, Yang Y, Gravel P, Toyonaga T, Sadabad F, Koohsari S, Pittman B, Gallezot J, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Rodden I, Hillmer A, Esterlis I, Ropchan J, Nabulsi N, Huang Y, Wolf J, Carson R, McPartland J, Matuskey D. Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism. American Journal Of Psychiatry 2025, 183: 58-69. PMID: 41366835, DOI: 10.1176/appi.ajp.20241084.Peer-Reviewed Original ResearchAutistic adults have lower levels of a key brain receptor linked to excitatory activity, suggesting a molecular basis for altered brain function in autism.Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT
Volpi T, Toyonaga T, Khattar N, Gallezot J, Naganawa M, Vanderlinden G, Honhar P, Zeng T, Fontaine K, Mulnix T, Hu L, Sun X, Henry S, Matuskey D, Radhakrishnan R, Guo L, Hu Y, Zhang J, Zheng X, Nabulsi N, Huang Y, Badawi R, Cherry S, Hillmer A, Jones T, Liu C, Morris E, Qi J, Li H, Carson R. Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 53: 2110-2121. PMID: 41177836, PMCID: PMC12860869, DOI: 10.1007/s00259-025-07605-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStandardized uptake valueTargeted radiopharmaceuticalsDopamine systemMultiple cortical areasSerotonin transporterRaphe nucleusMeasurement of tracer uptakeBrain regionsBrain structuresSubcortical nucleiPositron emission tomographyCortical areasSynaptic densityPET researchFocal uptakePaired scansUptake valueTracer uptakePET systemGray matterEarly imagesEmission tomographyHealthy individualsTracer deliveryNeuroExplorerYRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography
Najmaoui Y, Chemli Y, Toussaint M, Petibon Y, Marty B, Fontaine K, Gallezot J, Razdevsek G, Orehar M, Dhaynaut M, Guehl N, Dolenec R, Pestotnik R, Johnson K, Ouyang J, Normandin M, Tetrault M, Lecomte R, Fakhri G, Marin T. YRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, 10: 535-546. PMID: 41424471, PMCID: PMC12714321, DOI: 10.1109/trpms.2025.3619872.Peer-Reviewed Original ResearchThis study introduces YRT-PET, an open-source GPU-accelerated software for PET image reconstruction, demonstrating high flexibility, speed, and compatibility with existing tools for dynamic imaging and motion correction.
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Radiology & Biomedical Imaging
PO Box 208042
New Haven, CT 06520-8042
United States