2025
The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas
Jester N, Singh M, Lorr S, Tommasini S, Wiznia D, Buono F. The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas. Scientific Reports 2025, 15: 5918. PMID: 39966622, PMCID: PMC11836447, DOI: 10.1038/s41598-025-88589-x.Peer-Reviewed Original ResearchConceptsGround-truth datasetDice scoreVestibular schwannomaImage processing accuracyVolumetric analysisML-based algorithmsMeasuring tumor sizeMean dice scoreAuto-segmentation toolAccurate AIAI modelsTumor sizeTumor modelVS tumorsTumor growthTesting stageAI-LTumorImage processing softwareClinical practicePatient recruitmentProcessing softwareSchwannomaDatasetManual segmentationCochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study
Marinelli J, Rahne T, Dornhoffer J, Lohse C, Cottrell J, Roland J, Thompson N, Brown K, Lucas J, Babu S, Lindquist N, Perkins E, Tan D, Lane J, Hunter J, Harvey E, Deep N, Cerasiello S, Kircher M, Espahbodi M, Tooker E, West N, Caye-Thomasen P, Carlson M, Plontke S. Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study. Otology & Neurotology 2025, 46: 10-18. PMID: 39666742, DOI: 10.1097/mao.0000000000004362.Peer-Reviewed Original ResearchConceptsIpsilateral cochlear implantationOpen-set speech perceptionCochlear implantationSpeech perceptionSpeech perception test scoresGross total resectionSpeech perception scoresSpeech perception testsSpeech perception outcomesCochlear implant performanceAudiometric follow-upAcademic medical centerTotal resectionTertiary academic medical centerPerception outcomesInternational multi-institutional studyPerception scoresHigh-complexity tumorsLow complexity tumorsMedian scoreIncomplete tumor resectionPerception testsMulti-institutional studyMedical CenterStatistically significant difference
2024
Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment
Singh K, Abdou H, Panth N, Chiang V, Buono F, Schwartz N, Mahajan A. Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment. Otology & Neurotology 2024, 46: 196-200. PMID: 39792983, DOI: 10.1097/mao.0000000000004392.Peer-Reviewed Original ResearchConceptsTumor volume assessmentABC/2 methodVestibular schwannomaVolume assessmentPlanimetry methodTumor volumeTumor volume changesFollow-up scansOverestimate tumor volumePatients' quality of lifeTumor sizeRetrospective reviewIntracranial tumorsImprove clinical decision makingSubgroup analysisVolumetric assessmentTumorClinical decision makingQuality of lifePatients' qualityPatientsClinical settingPlanimetryImaging techniquesPositive correlationComparing Cochlear Implant Outcomes in 100 Patients With Sporadic Vestibular Schwannoma Managed With Observation, Radiosurgery, or Microsurgery: A Multi-Institutional Review
Dornhoffer J, Marinelli J, Lohse C, Cottrell J, McMenomey S, Roland J, Thompson N, Brown K, Lucas J, Babu S, Lindquist N, Perkins E, Rahne T, Plontke S, Tan D, Hunter J, Harvey E, Deep N, Cerasiello S, Kircher M, Espahbodi M, Tooker E, Lloyd S, Carlson M. Comparing Cochlear Implant Outcomes in 100 Patients With Sporadic Vestibular Schwannoma Managed With Observation, Radiosurgery, or Microsurgery: A Multi-Institutional Review. Otology & Neurotology 2024, 45: e719-e726. PMID: 39514427, DOI: 10.1097/mao.0000000000004298.Peer-Reviewed Original ResearchConceptsOpen-set speech perceptionCochlear implantationSpeech perceptionSpeech perception test scoresSpeech perception outcomesSpeech perception scoresCochlear implant outcomesPure-tone thresholdsPure-tone averageImplant outcomesSporadic VSVestibular schwannomaIpsilateral CIPerception outcomesVestibular schwannoma managementTreated with observationPerception scoresMulti-institutional reviewSporadic vestibular schwannomaMicrosurgical resectionPatient counselingMultimodal therapyTumor managementRadiosurgeryPatientsSingle-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs
Wang T, Ling A, Billings S, Hosseini D, Vaisbuch Y, Kim G, Atkinson P, Sayyid Z, Aaron K, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore L, Maria P, Blevins N, Jackler R, Alyono J, Kveton J, Navaratnam D, Heller S, Lopez I, Grillet N, Jan T, Cheng A. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nature Communications 2024, 15: 4833. PMID: 38844821, PMCID: PMC11156867, DOI: 10.1038/s41467-024-48491-y.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptome atlasInner ear hair cell lossNon-sensory cell typesCell regeneration in vivoVestibular schwannoma patientsTranscriptomic atlasHair cellsHair cell lossIGF-1 signalingHuman inner earMouse hair cellsCell trajectory analysisSchwannoma patientsDynamic gene expressionVestibular hair cellsPermanent hearingHair cell precursorsIGF-1Cell lossCell precursorsInner earRegenerative capacityMurine utriclesCell typesGene expression
2023
CyberKnife Stereotactic Radiosurgery for Growing Vestibular Schwannoma: Longitudinal Tumor Control, Hearing Outcomes, and Predicting Post‐Treatment Hearing Status
Hildrew D, Perez P, Mady L, Li J, Nilsen M, Hirsch B. CyberKnife Stereotactic Radiosurgery for Growing Vestibular Schwannoma: Longitudinal Tumor Control, Hearing Outcomes, and Predicting Post‐Treatment Hearing Status. The Laryngoscope 2023, 134: s1-s12. PMID: 37178050, DOI: 10.1002/lary.30731.Peer-Reviewed Original ResearchMeSH KeywordsFollow-Up StudiesHearingHearing LossHumansNeuroma, AcousticRadiosurgeryRetrospective StudiesTreatment OutcomeConceptsTumor control rateCyberKnife stereotactic radiosurgeryHearing outcomesVestibular schwannomaControl rateStereotactic radiosurgeryRetrospective case series reviewCase series reviewThird of patientsProportional hazard modelingMaximum radiation doseSeries reviewTumor controlAvailable audiogramsOtolaryngology-HeadTumor volumeEffective treatmentClass APatientsHearing statusAmerican AcademyHazard modelingVolumetric analysisRadiation doseOutcomes
2022
Endoscopic Endonasal Eustachian Tube Obliteration as a Treatment for Tension Pneumocephalus After Translabyrinthine Resection of Vestibular Schwannoma
Ji KSY, Rimmer R, Dogan A, Cetas JS, Ciporen JN, Sanusi O, Gupta S, Geltzeiler M. Endoscopic Endonasal Eustachian Tube Obliteration as a Treatment for Tension Pneumocephalus After Translabyrinthine Resection of Vestibular Schwannoma. Otology & Neurotology 2022, 43: e856-e860. PMID: 35970161, DOI: 10.1097/mao.0000000000003606.Peer-Reviewed Original ResearchMeSH KeywordsCerebrospinal Fluid LeakEndoscopyEustachian TubeHumansMaleMiddle AgedNeuroma, AcousticPneumocephalusPostoperative ComplicationsConceptsEustachian tube obliterationCerebrospinal fluid leakV-Loc sutureTranslabyrinthine resectionVestibular schwannomaMental statusThird ventricleComputed tomographyFluid leakTension pneumocephalusCerebellopontine angle massPatient's mental statusLateral skull base surgeryRight frontal lobeOriginal surgical siteSkull base surgeryTranslabyrinthine excisionDevastating complicationLateral ventricleResection cavityMAIN OUTCOMESurgical siteFrontal lobePneumocephalusSuture techniqueEndoscopic Endonasal Eustachian Tube Obliteration for Cerebrospinal Fluid Rhinorrhea: A Case Series and Scoping Review
Rimmer R, Lilly G, Gupta S, Ciporen J, Detwiller K, Cetas J, Dogan A, Geltzeiler M. Endoscopic Endonasal Eustachian Tube Obliteration for Cerebrospinal Fluid Rhinorrhea: A Case Series and Scoping Review. Operative Neurosurgery 2022, 22: 345-354. PMID: 35867077, DOI: 10.1227/ons.0000000000000158.Peer-Reviewed Original ResearchMeSH KeywordsCerebrospinal Fluid RhinorrheaEndoscopyEustachian TubeHumansNeuroma, AcousticRetrospective StudiesConceptsCerebrospinal fluid rhinorrheaEustachian tube obliterationLateral skull base surgeryCase seriesSkull base surgeryPrior surgical attemptsRetrospective chart reviewSmall case seriesInitial success rateBarbed suture techniqueNew case seriesTranslabyrinthine resectionChart reviewRetrospective seriesVestibular schwannomaRevision surgeryLumbar drainSurgical attemptsRevision casesPatientsBarbed sutureSuture techniqueSurgeryValuable option
2020
Manual segmentation versus semi-automated segmentation for quantifying vestibular schwannoma volume on MRI
McGrath H, Li P, Dorent R, Bradford R, Saeed S, Bisdas S, Ourselin S, Shapey J, Vercauteren T. Manual segmentation versus semi-automated segmentation for quantifying vestibular schwannoma volume on MRI. International Journal Of Computer Assisted Radiology And Surgery 2020, 15: 1445-1455. PMID: 32676869, PMCID: PMC7419453, DOI: 10.1007/s11548-020-02222-y.Peer-Reviewed Original ResearchConceptsManual segmentationHigh quality softwareTime-intensive taskGeneric softwareIntensive tasksSegmentation accuracySegmentation timeSegmentation approachVestibular schwannomaSegmentationSegmentation effortsApplicable solutionSoftwareReference approachCurrent clinical practiceVestibular schwannoma volumeAccuracyContrast agent injectionVolumetric measurementsEqual performanceTumor sizeVS sizeClinical practiceMore frustrationAgent injectionClinical and economic burden of neurofibromatosis type 2 in the United States
Koo AB, Yeung JT, Freedman IG, Lee JH, Ahmed OM, Ma AK, Miyagishima DF, DiLuna M, Kahle K. Clinical and economic burden of neurofibromatosis type 2 in the United States. Clinical Neurology And Neurosurgery 2020, 197: 106053. PMID: 32683193, DOI: 10.1016/j.clineuro.2020.106053.Peer-Reviewed Original ResearchConceptsOpen resectionPatient demographicsRisk factorsMeningioma resectionMulti-year cross-sectional studyNeurofibromatosis type 2 (NF2) patientsSpine tumor resectionCommon admission diagnosesNational Inpatient SampleType 2 patientsCross-sectional studySignificant independent associationNeurofibromatosis type 2Regression analysisInflation-adjusted costAdmission diagnosisHospital stayDischarge weightIndependent predictorsObstructive hydrocephalusSurgical interventionDiagnosis codesHospital characteristicsInpatient populationInpatient SampleMRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection
Schwartz N, Rooth MA, Dillon MT, O'Connell BP, Dedmon MM, Huang BY, Brown KD. MRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection. American Journal Of Otolaryngology 2020, 41: 102518. PMID: 32451290, DOI: 10.1016/j.amjoto.2020.102518.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCochlear ImplantationCochlear NerveCranial Nerve NeoplasmsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMonitoring, PhysiologicNeuroma, AcousticOrgan Sparing TreatmentsPostoperative PeriodRetrospective StudiesVestibulocochlear NerveVestibulocochlear Nerve DiseasesConceptsInternal auditory canalConcurrent cochlear implantationVestibular schwannoma resectionIpsilateral internal auditory canalCerebellopontine angleSchwannoma resectionCochlear nerveCochlear implantationHead MRITranslabyrinthine vestibular schwannoma resectionCochlear implant magnetResidual tumor growthCI recipientsMagnetic resonance imaging (MRI) monitoringTranslabyrinthine excisionImplant magnetMRI surveillanceRetrospective reviewVS tumorsTumor recurrenceAuditory canalSerial monitoringCI magnetExcellent visualizationTumor growth
2016
Development of an evidence-based decision pathway for vestibular schwannoma treatment options
Linkov F, Valappil B, McAfee J, Goughnour SL, Hildrew DM, McCall AA, Linkov I, Hirsch B, Snyderman C. Development of an evidence-based decision pathway for vestibular schwannoma treatment options. American Journal Of Otolaryngology 2016, 38: 57-64. PMID: 27780583, DOI: 10.1016/j.amjoto.2016.09.019.Peer-Reviewed Original ResearchConceptsVestibular schwannomaGroup of patientsPost-operative symptomsEvidence-based dataPittsburgh Medical CenterEffectiveness of treatmentQuality of lifeComplex medical problemsHealth care systemTreatment Decision Support SystemVS patientsTreatment optionsTreatment pathwaysTreatment decisionsMedical CenterClinical informationTreatment selectionFocus groupsSide effectsPatient valuesPatientsPatient feedbackClinical investigatorsTreatment alternativesMedical problems
2015
3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma
Schneider T, Chapiro J, Lin M, Geschwind JF, Kleinberg L, Rigamonti D, Jusué-Torres I, Marciscano AE, Yousem DM. 3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma. European Radiology 2015, 26: 849-857. PMID: 26139318, PMCID: PMC4698362, DOI: 10.1007/s00330-015-3895-9.Peer-Reviewed Original ResearchConceptsSingle-session stereotactic radiosurgeryTotal tumor volumeSignificant tumor shrinkageVestibular schwannomaTumor shrinkageStereotactic radiotherapyTumor volumeRadiation therapyStereotactic radiosurgeryT1-weighted contrast-enhanced MRISubsequent microsurgical resectionTumor-related symptomsSporadic vestibular schwannomaContrast-enhanced MRIFSRT groupRadiological progressionMicrosurgical resectionClinical outcomesSRS groupRetrospective analysisResponse assessmentPatientsVolumetric assessmentFSRTSchwannoma
2014
Acoustic neuroma: potential risk factors and audiometric surveillance in the aluminium industry
Taiwo O, Galusha D, Tessier-Sherman B, Kirsche S, Cantley L, Slade MD, Cullen MR, Donoghue AM. Acoustic neuroma: potential risk factors and audiometric surveillance in the aluminium industry. Occupational And Environmental Medicine 2014, 71: 624. PMID: 25015928, PMCID: PMC4145445, DOI: 10.1136/oemed-2014-102094.Peer-Reviewed Original ResearchConceptsHearing conservation programAcoustic neuromaRisk factorsMultivariate analysisPossible occupational risk factorsSignificant risk factorsOccupational risk factorsAluminum production workersPotential risk factorsCase-control analysisInsurance claims dataUndiagnosed tumorsIncidental detectionPopulation of workersHearing lossAudiometric surveillanceClaims dataMedical surveillanceDetection biasBivariate analysisNoise dose
2013
Secondary Neoplasms After Stereotactic Radiosurgery
Patel TR, Chiang VL. Secondary Neoplasms After Stereotactic Radiosurgery. World Neurosurgery 2013, 81: 594-599. PMID: 24148883, DOI: 10.1016/j.wneu.2013.10.043.Peer-Reviewed Original ResearchMeSH KeywordsCentral Nervous System NeoplasmsHumansNeoplasms, Radiation-InducedNeoplasms, Second PrimaryNeuroma, AcousticRadiosurgeryRisk FactorsConceptsStereotactic radiosurgerySecondary neoplasmsCentral nervous system diseaseLong-term surveillance imagingNervous system diseasesRadiation-induced neoplasmsLong-term riskInitial diagnosisSurveillance imagingVestibular schwannomaTreatment paradigmSubsequent riskSystem diseasesNeoplasmsMedical radiationRadiation exposureRadiosurgeryRiskPatientsSchwannomaYearsDiseaseDiagnosis
1996
Obliteration of the Eustachian Tube Using Hydroxyapatite Cement: A Permanent Technique
Kveton J. Obliteration of the Eustachian Tube Using Hydroxyapatite Cement: A Permanent Technique. The Laryngoscope 1996, 106: 1241-1243. PMID: 8849794, DOI: 10.1097/00005537-199610000-00014.Peer-Reviewed Original Research
1995
Indications for hydroxyapatite cement reconstruction in lateral skull base surgery.
Kveton J, Friedman C, Costantino P. Indications for hydroxyapatite cement reconstruction in lateral skull base surgery. Otology & Neurotology 1995, 16: 465-9. PMID: 8588646.Peer-Reviewed Original Research
1994
The effect of unilateral chorda tympani damage on taste
Kveton J, Bartoshuk L. The effect of unilateral chorda tympani damage on taste. The Laryngoscope 1994, 104: 25-29. PMID: 8295453, DOI: 10.1288/00005537-199401000-00006.Peer-Reviewed Original Research
1990
The efficacy of brainstem auditory evoked potentials in acoustic tumor surgery
Kveton J. The efficacy of brainstem auditory evoked potentials in acoustic tumor surgery. The Laryngoscope 1990, 100: 1171-1173. PMID: 2233078, DOI: 10.1288/00005537-199011000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAdultEvoked Potentials, Auditory, Brain StemHearingHumansMiddle AgedMonitoring, IntraoperativeNeuroma, AcousticConceptsBrainstem auditoryNerve monitoringTumor sizeAbsolute tumour sizeAcoustic tumor removalAcoustic tumor resectionHearing preservation resultsIntraoperative BAEP monitoringHearing preservation rateSeries of patientsAverage tumor sizeIdentification of patientsAcoustic tumor surgerySmall acoustic neuromasBAEP monitoringUnmonitored patientsPreoperative levelsNerve assessmentTumor resectionAcoustic neuromaTumor removalTumor surgeryPreservation ratePatientsFar-field recordingsDelayed spontaneous return of hearing after acoustic tumor surgery: Evidence for cochlear nerve conduction block
Kveton J. Delayed spontaneous return of hearing after acoustic tumor surgery: Evidence for cochlear nerve conduction block. The Laryngoscope 1990, 100: 473-476. PMID: 2329903, DOI: 10.1288/00005537-199005000-00006.Peer-Reviewed Original ResearchConceptsAcoustic tumor resectionCochlear nerveFacial nerveTumor resectionConduction blockIntact cochlear nerveInternal auditory arteryIntact facial nerveAcoustic tumor surgeryNerve conduction blockReversible conduction blockHearing recoveryMost patientsHearing lossTumor surgeryFacial paralysisMechanical traumaSpontaneous returnNerveEventual resolutionResectionBlock phenomenonSpasmPatientsSurgery
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